Tc17细胞对乙肝相关慢加急性肝衰竭病情进展及乙肝病毒清除的影响

R512.6; [目的]探讨Tc17细胞表达对乙肝相关慢加急性肝衰竭(HBV-ACLF)病情进展及乙肝病毒清除的影响.[方法]纳入43例HBV-ACLF患者,以20例慢性乙型肝炎患者(CHB)和12例健康体检者(NC)为对照,流式细胞术检测外周血中Tc17细胞的表达,荧光定量PCR法检测HBV-DNA载量,采用MELD、MELD-Na、CLIF-C ACLF及AARC评分等指标评估患者病情,分析Tc17细胞表达对病情进展及乙肝病毒清除的影响.[结果]与NC组及CHB组比较,HBV-ACLF患者Tc17细胞表达明显升高(P<0.001及P=0.017).相关分析发现Tc17细胞与AARC评...

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Published inZhongshan da xue xue bao. Zhongshan daxue xuebao yixue kexue ban = Journal of Sun Yat-sen University. Yi xue ke xue ban Vol. 40; no. 5; pp. 739 - 746
Main Authors 张耿林, 徐士丞, 张婷, 林潮双, 彭亮, 高志良
Format Journal Article
LanguageChinese
Published 中山大学附属第三医院感染科,广东广州,510630%中山大学附属第三医院超声科,广东广州,510630 2019
Editorial Office of Journal of Sun Yat-sen University
Subjects
Tc17细胞
乙型肝炎病毒
慢加急性肝衰竭
Tc17细胞
慢加急性肝衰竭
乙型肝炎病毒
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ISSN1672-3554

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Abstract R512.6; [目的]探讨Tc17细胞表达对乙肝相关慢加急性肝衰竭(HBV-ACLF)病情进展及乙肝病毒清除的影响.[方法]纳入43例HBV-ACLF患者,以20例慢性乙型肝炎患者(CHB)和12例健康体检者(NC)为对照,流式细胞术检测外周血中Tc17细胞的表达,荧光定量PCR法检测HBV-DNA载量,采用MELD、MELD-Na、CLIF-C ACLF及AARC评分等指标评估患者病情,分析Tc17细胞表达对病情进展及乙肝病毒清除的影响.[结果]与NC组及CHB组比较,HBV-ACLF患者Tc17细胞表达明显升高(P<0.001及P=0.017).相关分析发现Tc17细胞与AARC评分、MELD评分及MELD-Na评分均成正相关(r=0.504,P=0.001;r=0.417,P=0.005及r=0.382,P=0.012),而与CLIF-C ACLF评分有相关趋势(r=0.294,P=0.055);且随着病情进展,Tc17细胞的表达逐渐升高.另外发现Tc17细胞与基线HBV-DNA载量成正相关(r=0.339,P=0.026),且Tc17细胞高表达的HBV-ACLF患者4周后HBV-DNA下降较低表达组更明显(P<0.001);多因素线性回归分析发现只有基线Tc17细胞及谷草转氨酶水平与HBV-DNA下降有关.[结论]Tc17细胞介导的炎症反应有助于清除HBV-DNA,但过激的炎症反应将导致患者病情进展.
AbstractList 【目的】探讨Tc17细胞表达对乙肝相关慢加急性肝衰竭（HBV-ACLF）病情进展及乙肝病毒清除的影响。【方法】纳入43例HBV-ACLF患者，以20例慢性乙型肝炎患者（CHB）和12例健康体检者（NC）为对照，流式细胞术检测外周血中Tc17细胞的表达，荧光定量PCR法检测HBV-DNA载量，采用MELD、MELD-Na、CLIF-CACLF及AARC评分等指标评估患者病情，分析Tc17细胞表达对病情进展及乙肝病毒清除的影响。【结果】与NC组及CHB组比较，HBV-ACLF患者Tc17细胞表达明显升高（P<0.001及P=0.017）。相关分析发现Tc17细胞与AARC评分、MELD评分及MELD-Na评分均成正相关（r=0.504，P=0.001；r=0.417，P=0.005及r=0.382，P=0.012），而与CLIF-CACLF评分有相关趋势（r=0.294，P=0.055）；且随着病情进展，Tc17细胞的表达逐渐升高。另外发现Tc17细胞与基线HBV-DNA载量成正相关（r=0.339，P=0.026），且Tc17细胞高表达的HBV-ACLF患者4周后HBV-DNA下降较低表达组更明显（P<0.001）；多因素线性回归分析发现只有基线Tc17细胞及谷草转氨酶水平与HBV-DNA下降有关。【结论】Tc17细胞介导的炎症反应有助于清除HBV-DNA，但过激的炎症反应将导致患者病情进展。
R512.6; [目的]探讨Tc17细胞表达对乙肝相关慢加急性肝衰竭(HBV-ACLF)病情进展及乙肝病毒清除的影响.[方法]纳入43例HBV-ACLF患者,以20例慢性乙型肝炎患者(CHB)和12例健康体检者(NC)为对照,流式细胞术检测外周血中Tc17细胞的表达,荧光定量PCR法检测HBV-DNA载量,采用MELD、MELD-Na、CLIF-C ACLF及AARC评分等指标评估患者病情,分析Tc17细胞表达对病情进展及乙肝病毒清除的影响.[结果]与NC组及CHB组比较,HBV-ACLF患者Tc17细胞表达明显升高(P<0.001及P=0.017).相关分析发现Tc17细胞与AARC评分、MELD评分及MELD-Na评分均成正相关(r=0.504,P=0.001;r=0.417,P=0.005及r=0.382,P=0.012),而与CLIF-C ACLF评分有相关趋势(r=0.294,P=0.055);且随着病情进展,Tc17细胞的表达逐渐升高.另外发现Tc17细胞与基线HBV-DNA载量成正相关(r=0.339,P=0.026),且Tc17细胞高表达的HBV-ACLF患者4周后HBV-DNA下降较低表达组更明显(P<0.001);多因素线性回归分析发现只有基线Tc17细胞及谷草转氨酶水平与HBV-DNA下降有关.[结论]Tc17细胞介导的炎症反应有助于清除HBV-DNA,但过激的炎症反应将导致患者病情进展.
Author 高志良
徐士丞
彭亮
张婷
张耿林
林潮双
AuthorAffiliation 中山大学附属第三医院感染科,广东广州,510630%中山大学附属第三医院超声科,广东广州,510630
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Author_FL ZHANG Geng-lin
XU Shi-cheng
ZHANG Ting
LIN Chao-shuang
PENG Liang
GAO Zhi-liang
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慢加急性肝衰竭
乙型肝炎病毒
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SubjectTerms Tc17细胞
乙型肝炎病毒
慢加急性肝衰竭
Title Tc17细胞对乙肝相关慢加急性肝衰竭病情进展及乙肝病毒清除的影响
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