Macrophage extracellular traps require peptidylarginine deiminase 2 and 4 and are a source of citrullinated antigens bound by rheumatoid arthritis autoantibodies

• Published in: The Journal of immunology (1950) Vol. 210; no. 1_Supplement; pp. 247 - 247.07
• Main Authors: Bashar, S. Janna, Holmes, Caitlyn, Shelef, Miriam
• Format: Journal Article
• Language: English
• Published: 01.05.2023

Anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis, but the sources of citrullinated antigens remain incompletely defined. Neutrophil extracellular traps (NETs) appear to be a source of ACPA targets. However, while the citrullinating enzyme peptidylarginine deiminas...