Dopamine D 1 Receptor Agonist PET Tracer Development: Assessment in Nonhuman Primates

• Published in: Journal of Nuclear Medicine Vol. 62; no. 9; pp. 1307 - 1313
• Main Authors: Barret, Olivier, Zhang, Lei, Alagille, David, Constantinescu, Cristian C., Sandiego, Christine, Papin, Caroline, Sullivan, Jenna M., Morley, Thomas, Carroll, Vincent M., Seibyl, John, Chen, Jianqing, Lee, Chewah, Villalobos, Anabella, Gray, David, McCarthy, Timothy J., Tamagnan, Gilles
• Format: Journal Article
• Language: English
• Published: United States Society of Nuclear Medicine 01.09.2021
• Subjects: Animals; Brain - diagnostic imaging; Brain - metabolism; Dopamine Agonists - pharmacokinetics; Dopamine Agonists - pharmacology; Life Sciences; Macaca fascicularis; Macaca mulatta; Male; Positron-Emission Tomography - methods; Radioactive Tracers; Radiopharmaceuticals - pharmacokinetics; Receptors, Dopamine D1 - agonists; Receptors, Dopamine D1 - antagonists & inhibitors; Receptors, Dopamine D1 - metabolism; Tissue Distribution; Parkinson disease; agonist; schizophrenia; D1 receptor; PET imaging

Non-catechol-based high-affinity selective dopamine D receptor (D1R) agonists were recently described, and candidate PET ligands were selected on the basis of favorable properties. The objective of this study was to characterize in vivo in nonhuman primates 2 novel D1R agonist PET radiotracers, race...