Abstract 2635: N-Myristolytransferase (NMT) inhibitors as novel potent payloads for antibody drug conjugates

• Published in: Cancer research (Chicago, Ill.) Vol. 83; no. 7_Supplement; p. 2635
• Main Authors: Carr, Robin A., Solari, Roberto, D'Arcy, Nikki, Tate, Ed, Walton, Josephine, Orafidiya, Folake
• Format: Journal Article
• Language: English
• Published: 04.04.2023

Abstract Introduction: There is a need for ADC payloads with an improved therapeutic index, consequently we have coupled potent and selective inhibitors of NMT to trastuzumab to test their potential in both in vitro and in vivo models. Experimental Procedures: A highly potent NMT inhibitor was conju...