Abstract 13204: Single-Nucleus Multiomic Analyses Identifies Gene Regulatory Dynamics of Phenotypic Modulation in Human Aneurysmal Aortic Root

• Published in: Circulation (New York, N.Y.) Vol. 148; no. Suppl_1; p. A13204
• Main Authors: Zeng, Qingyi, Liu, Xuanyu, Zhou, Zhou
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 07.11.2023
• Subjects: Cell physiology; Smooth muscle regulation; Thoracic Aorta; Aortic aneurysm; Marfan's Syndrome

Introduction: Aortic root aneurysm is a potentially life-threatening condition because it may lead to aortic rupture. However, a single-nucleus transcriptomic and epigenomic landscape in the aortic root tissue of humans is lacking, and the regulatory mechanism of pathogenesis in aneurysmal aortic ro...