Estimating the Contribution of Proteasomal Spliced Peptides to the HLA-I Ligandome

• Published in: bioRxiv
• Main Authors: Mylonas, Roman, Beer, Ilan, Iseli, Christian, Chong, Chloe, Pak, Huisong, Gfeller, David, Coukos, George, Xenarios, Ioannis, Mueller, Markus, Bassani-Sternberg, Michal
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 18.05.2018
• Subjects: Computer applications; Histocompatibility antigen HLA; Peptides; Proteasomes; Splicing

Spliced peptides are short protein fragments spliced together in the proteasome by peptide bond formation. True estimation of the contribution of proteasome-spliced peptides (PSPs) to the global Human Leukocyte Antigen (HLA) ligandome is critical. A recent study suggested that PSPs contribute up to...