Slowed relaxation of diaphragm in septic rats is associated with reduced expression of sarco-endoplasmic reticulum CA 2+ -ATPase genes SERCA1 and SERCA2

• Published in: Muscle & nerve Vol. 54; no. 6; pp. 1108 - 1113
• Main Authors: Wu, Jin, Zhang, Jian You, Gong, Yuan, Li, Shi Tong
• Format: Journal Article
• Language: English
• Published: United States 01.12.2016
• Subjects: Animals; Cecostomy - adverse effects; Cecum - surgery; Diaphragm - metabolism; Diaphragm - physiopathology; Disease Models, Animal; Electric Stimulation; Gene Expression Regulation, Enzymologic - physiology; In Vitro Techniques; Ligation - adverse effects; Muscle Contraction - physiology; Rats; RNA, Messenger - metabolism; Ryanodine Receptor Calcium Release Channel - genetics; Ryanodine Receptor Calcium Release Channel - metabolism; Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics; Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism; Sepsis - etiology; Sepsis - pathology; diaphragm; ryanodine receptor; SERCA; muscle relaxation; sepsis; muscle weakness

The aim of this study was to study the effects of sepsis on diaphragm relaxation properties and the associated expression of sarco-endoplasmic reticulum Ca -ATPase genes SERCA1 and SERCA2. Rats were randomized to undergo either sham surgery or cecal ligation and puncture (CLP). Diaphragm isometric r...