Abstract B075: The role of TET1 and hydroxymethylation in high-risk prostate cancer

• Published in: Cancer research (Chicago, Ill.) Vol. 78; no. 16_Supplement; p. B075
• Main Authors: Smeets, Elien, Spans, Lien, Prekovic, Stefan, Broeck, Thomas Van den, Moris, Lisa, Gevaert, Thomas, Helsen, Christine, Joniau, Steven, Claessens, Frank
• Format: Journal Article
• Language: English
• Published: 15.08.2018

The Ten-eleven translocation (TET) proteins are dioxygenases that catalyze the oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) as part of the DNA demethylation pathway. Gene silencing through cytosine methylation contributes to cancer formation, but how hydroxymethylation affec...