Proteínas séricas de potros da raça Puro Sangue Árabe recém-desmamados ou com mais de trinta dias de desmame

A fase perinatal do desenvolvimento constitui um dos períodos de vida mais desafiadores para o sistema imunológico dos potros. O objetivo do presente estudo foi verificar o perfil protéico sérico de parâmetros relacionados à imunidade de equinos jovens no período perinatal, verificando-se a transfer...

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Published inPesquisa veterinária brasileira Vol. 31; no. suppl 1; pp. 89 - 93
Main Authors Favero, Diego Horcajo Martinez Fudoli, Dias, Deborah Penteado Martins, Feringer-Junior, Walter Heinz, Bernardi, Nara Saraiva, Lacerda-Neto, José Corrêa de
Format Journal Article
LanguageEnglish
Published 01.12.2011
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Abstract A fase perinatal do desenvolvimento constitui um dos períodos de vida mais desafiadores para o sistema imunológico dos potros. O objetivo do presente estudo foi verificar o perfil protéico sérico de parâmetros relacionados à imunidade de equinos jovens no período perinatal, verificando-se a transferência de imunidade passiva. Oito animais desmamados há um dia, formaram o Grupo 1 (G1), enquanto vinte animais desmamados há mais de trinta dias formaram o Grupo 2 (G2). A concentração sérica de proteína total foi determinada por refratometria. Para o fracionamento das proteínas, utilizou-se eletroforese em gel de acrilamida. Os resultados obtidos foram submetidos à análise de medidas repetidas e ao teste Tukey (p<0,05) para comparação das médias. As concentrações de IgA apresentaram diferença (p<0,05) entre os grupos, porém os valores observados encontravam-se dentro do considerado normal para equinos adultos. Não houve diferença (p>0,05) nas concentrações de IgG. O estabelecimento adequado da imunidade celular ocorre durante a fase neonatal, nos animais que ingerem adequadamente o colostro e o leite. O presente estudo determinou diferenças no perfil protéico sérico de parâmetros relacionados à imunidade de equinos jovens no período imediato ao desmame, comparados com animais desmamados há mais de 30 dias. De acordo com os valores observados, concluiu-se que os animais, mesmo desmamados precocemente, obtiveram transferência adequada de imunidade passiva. The perinatal phase of foal development is one of the most challenger period for the immune system. The present study has analyzed serum protein profile, considering variables related to immunity in foals at the perinatal phase, verifying passive immunity transfer. The group 1 (G1) contained eight foals evaluated one day after weaning, and group 2 (G2) included twenty foals at more than thirty days after weaning. Total protein concentration was determined by means of refractometry. The concentration of serum proteins was determined through sodium dodecyl sulphatepolyacrylamide gel electrophoresis. Results were submitted to analysis of variance and Tukey test (P<0.05). IgA concentration showed difference (P<0.05) between the two studied groups, however data were within adult healthy horses normal values. IgG didn't show statistical difference (P>0.05). The cellular immunity establishment occurs in the neonatal phase, in foals that suckled colostrum and milk properly. The present study showed differences in serum protein profile, considering variables related to immunity, in foals immediately after weaning comparing to foals at more than 30 days after weaning. According to the observed values, we conclude that foals, even early weaned, showed proper passive immunity tranfer.
AbstractList A fase perinatal do desenvolvimento constitui um dos períodos de vida mais desafiadores para o sistema imunológico dos potros. O objetivo do presente estudo foi verificar o perfil protéico sérico de parâmetros relacionados à imunidade de equinos jovens no período perinatal, verificando-se a transferência de imunidade passiva. Oito animais desmamados há um dia, formaram o Grupo 1 (G1), enquanto vinte animais desmamados há mais de trinta dias formaram o Grupo 2 (G2). A concentração sérica de proteína total foi determinada por refratometria. Para o fracionamento das proteínas, utilizou-se eletroforese em gel de acrilamida. Os resultados obtidos foram submetidos à análise de medidas repetidas e ao teste Tukey (p<0,05) para comparação das médias. As concentrações de IgA apresentaram diferença (p<0,05) entre os grupos, porém os valores observados encontravam-se dentro do considerado normal para equinos adultos. Não houve diferença (p>0,05) nas concentrações de IgG. O estabelecimento adequado da imunidade celular ocorre durante a fase neonatal, nos animais que ingerem adequadamente o colostro e o leite. O presente estudo determinou diferenças no perfil protéico sérico de parâmetros relacionados à imunidade de equinos jovens no período imediato ao desmame, comparados com animais desmamados há mais de 30 dias. De acordo com os valores observados, concluiu-se que os animais, mesmo desmamados precocemente, obtiveram transferência adequada de imunidade passiva. The perinatal phase of foal development is one of the most challenger period for the immune system. The present study has analyzed serum protein profile, considering variables related to immunity in foals at the perinatal phase, verifying passive immunity transfer. The group 1 (G1) contained eight foals evaluated one day after weaning, and group 2 (G2) included twenty foals at more than thirty days after weaning. Total protein concentration was determined by means of refractometry. The concentration of serum proteins was determined through sodium dodecyl sulphatepolyacrylamide gel electrophoresis. Results were submitted to analysis of variance and Tukey test (P<0.05). IgA concentration showed difference (P<0.05) between the two studied groups, however data were within adult healthy horses normal values. IgG didn't show statistical difference (P>0.05). The cellular immunity establishment occurs in the neonatal phase, in foals that suckled colostrum and milk properly. The present study showed differences in serum protein profile, considering variables related to immunity, in foals immediately after weaning comparing to foals at more than 30 days after weaning. According to the observed values, we conclude that foals, even early weaned, showed proper passive immunity tranfer.
Author Favero, Diego Horcajo Martinez Fudoli
Dias, Deborah Penteado Martins
Lacerda-Neto, José Corrêa de
Feringer-Junior, Walter Heinz
Bernardi, Nara Saraiva
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10.1111/j.2042-3292.1997.tb01279.x
10.1111/j.1939-1676.1991.tb03147.x
10.1136/vr.128.18.416
10.1016/S0260-4639(22)00144-X
10.1016/j.cveq.2008.03.005
10.1111/j.2042-3306.1983.tb01826.x
10.2527/jas.2008-1377
10.1016/S0749-0704(18)30249-5
10.1016/j.cveq.2008.03.004
10.1016/j.tvjl.2003.08.004
10.1042/bj2650621
10.2460/javma.1992.200.02.179
10.1038/227680a0
10.1111/j.1751-0813.1996.tb10035.x
10.1111/j.1751-0813.2005.tb12202.x
10.1016/j.tvjl.2007.05.018
10.1016/j.vetmic.2011.03.017
10.3168/jds.S0022-0302(69)86871-2
10.1016/j.jevs.2009.04.177
10.1590/S0071-12761991000100007
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References LeBlanc M.M (ref21) 1992; 200
Parish S.M (ref27) 1996
Lima R.A.S (ref22) 2006
Heinrich P.C (ref12) 1990; 265
Frey Jr F (ref10) 2006
Koterba A.M (ref18) 1990
Raidal S.L (ref30) 2005; 83
Axon J.E (ref1) 2008; 24
Mellor D.J (ref24) 2004; 168
Crisman M.V (ref6) 2008; 24
Dawson T.R.M.Y (ref7) 2010; 135
Feitosa F.L.F (ref8) 1999; 2
Wicher J.T (ref39) 1985; 5
Paltrinieri S (ref26) 2008; 176
Henneke D.R (ref13) 1983; 15
Kuhl J (ref19) 2011; 151
McGuire T.C (ref23) 1977; 170
Stelwagen K (ref34) 2009; 87
Taylor F.G.R (ref36) 1997
Pfeiffer N.E (ref28) 1977; 38
Raidal S.L (ref29) 1996; 73
Clabough D.L (ref5) 1991; 5
Rumbaugh G.E (ref31) 1979; 174
Scotoni C.M.M (ref33) 1991; 48
Tizard I.R (ref37) 1998
Knottenbelt D.C (ref17) 2004
Tizard I.R (ref38) 2002
Chavatte P (ref4) 1997; 9
Kaneko J.J (ref15) 1997
Kenzig A.R (ref16) 2009; 29
Stoneham S.J (ref35) 1991; 128
Bierer B.W (ref2) 1969; 30
Morris D.D (ref25) 1986; 8
Rossdale P.D (ref32) 1979
Feldman B.C (ref9) 2000
Laemmli U.K (ref20) 1970; 227
Butler J.E (ref3) 1969; 52
Griffel M.I (ref11) 1992; 8
Jainudeen M.R (ref14) 1995
References_xml – volume: 170
  start-page: 1302
  year: 1977
  ident: ref23
  article-title: Failure of colostral immunoglobulin transfer as an explanation for most infections and deaths of neonatal foals
  publication-title: J. Am. Vet. Med. Assoc
  contributor:
    fullname: McGuire T.C
– year: 1997
  ident: ref36
  contributor:
    fullname: Taylor F.G.R
– year: 2006
  ident: ref10
  contributor:
    fullname: Frey Jr F
– year: 2000
  ident: ref9
  contributor:
    fullname: Feldman B.C
– volume: 135
  start-page: 1
  year: 2010
  ident: ref7
  article-title: Current understanding of the equine immune response to Rhodococcus equi: An immunological review of R. Equi pneumonia
  publication-title: Vet. Immunol. Immunopathol
  doi: 10.1016/j.vetimm.2009.12.004
  contributor:
    fullname: Dawson T.R.M.Y
– volume: 174
  start-page: 273
  year: 1979
  ident: ref31
  article-title: Identification and treatment of colostrum-deficient foals
  publication-title: J. Am. Vet. Med. Assoc
  contributor:
    fullname: Rumbaugh G.E
– volume: 9
  start-page: 62
  year: 1997
  ident: ref4
  article-title: Lactation in the mare
  publication-title: Equine Vet. Educ
  doi: 10.1111/j.2042-3292.1997.tb01279.x
  contributor:
    fullname: Chavatte P
– volume: 30
  start-page: 2237
  year: 1969
  ident: ref2
  article-title: Electrophoretic analysis of blood serum and plasma proteins of normal horses
  publication-title: Am. J. Vet. Res
  contributor:
    fullname: Bierer B.W
– volume: 5
  start-page: 335
  year: 1991
  ident: ref5
  article-title: Factors associated with failure of passive transfer of colostral antibodies in Standard-bred foals
  publication-title: J. Vet. Intern. Med
  doi: 10.1111/j.1939-1676.1991.tb03147.x
  contributor:
    fullname: Clabough D.L
– volume: 128
  start-page: 416
  year: 1991
  ident: ref35
  article-title: Failure of passive transfer of colostral immunity in the foal: incidence, and the effect of stud management and plasma transfusions
  publication-title: Vet. Rec
  doi: 10.1136/vr.128.18.416
  contributor:
    fullname: Stoneham S.J
– year: 1998
  ident: ref37
  contributor:
    fullname: Tizard I.R
– year: 2006
  ident: ref22
  contributor:
    fullname: Lima R.A.S
– volume: 5
  start-page: 425
  year: 1985
  ident: ref39
  article-title: Acute phase proteins
  publication-title: Clin. Immunol. Allergy
  doi: 10.1016/S0260-4639(22)00144-X
  contributor:
    fullname: Wicher J.T
– volume: 24
  start-page: 357
  year: 2008
  ident: ref1
  article-title: Clinical pathology of the foal
  publication-title: Vet. Clin. Equine
  doi: 10.1016/j.cveq.2008.03.005
  contributor:
    fullname: Axon J.E
– volume: 15
  start-page: 371
  year: 1983
  ident: ref13
  article-title: Relationship between body condition score, physical measurements and body fat percentage in mares
  publication-title: Equine Vet. J
  doi: 10.1111/j.2042-3306.1983.tb01826.x
  contributor:
    fullname: Henneke D.R
– volume: 87
  start-page: 3
  year: 2009
  ident: ref34
  article-title: Immune components of bovine colostrum and milk
  publication-title: J. Anim. Sci
  doi: 10.2527/jas.2008-1377
  contributor:
    fullname: Stelwagen K
– volume: 2
  start-page: 17
  year: 1999
  ident: ref8
  article-title: Importância da transferência da imunidade passiva para a sobrevivência de bezerros neonatos
  publication-title: Revta Educ. Contin
  contributor:
    fullname: Feitosa F.L.F
– volume: 8
  start-page: 235
  year: 1992
  ident: ref11
  article-title: Pharmacology of colloids and crystalloids
  publication-title: Crit. Care Clin
  doi: 10.1016/S0749-0704(18)30249-5
  contributor:
    fullname: Griffel M.I
– start-page: 217
  volume-title: Gestação, fisiologia pré-natal e parto
  year: 1995
  ident: ref14
  contributor:
    fullname: Jainudeen M.R
– volume: 24
  start-page: 285
  year: 2008
  ident: ref6
  article-title: Blood proteins and inflammation in the horse
  publication-title: Vet. Clin. Equine
  doi: 10.1016/j.cveq.2008.03.004
  contributor:
    fullname: Crisman M.V
– volume: 168
  start-page: 118
  year: 2004
  ident: ref24
  article-title: Animal welfare implications of neonatal mortality and morbidity in farm animals
  publication-title: Vet. J
  doi: 10.1016/j.tvjl.2003.08.004
  contributor:
    fullname: Mellor D.J
– volume: 265
  start-page: 621
  issn: 0264-6021
  year: 1990
  ident: ref12
  article-title: Interleukin-6 and the acute phase response
  publication-title: Biochem. J
  doi: 10.1042/bj2650621
  contributor:
    fullname: Heinrich P.C
– volume: 200
  start-page: 179
  year: 1992
  ident: ref21
  article-title: Factors that influence passive transfer of immunoglobulins in foals
  publication-title: J. Am. Vet. Med. Assoc
  doi: 10.2460/javma.1992.200.02.179
  contributor:
    fullname: LeBlanc M.M
– volume: 227
  start-page: 680
  issn: 0028-0836
  year: 1970
  ident: ref20
  article-title: Cleavage of structural proteins during the assembly of the head of bacteriophage T4
  publication-title: Nature
  doi: 10.1038/227680a0
  contributor:
    fullname: Laemmli U.K
– year: 2002
  ident: ref38
  contributor:
    fullname: Tizard I.R
– volume: 73
  start-page: 201
  issn: 0005-0423
  year: 1996
  ident: ref29
  article-title: The incidence and consequences of failure of passive transfer of immunity on a Thoroughbred breeding farm
  publication-title: Aust. Vet. J
  doi: 10.1111/j.1751-0813.1996.tb10035.x
  contributor:
    fullname: Raidal S.L
– year: 1979
  ident: ref32
  contributor:
    fullname: Rossdale P.D
– volume: 83
  start-page: 78
  issn: 0005-0423
  year: 2005
  ident: ref30
  article-title: Effect of withholding macromolecules on the duration of intestinal permeability to colostral IgG in foals
  publication-title: Aust. Vet. J
  doi: 10.1111/j.1751-0813.2005.tb12202.x
  contributor:
    fullname: Raidal S.L
– volume: 176
  start-page: 393
  year: 2008
  ident: ref26
  article-title: Influence of age and foaling on plasma protein electrophoresis and serum amyloid A and their possible role as markers of equine neonatal septicaemia
  publication-title: Vet. Journal
  doi: 10.1016/j.tvjl.2007.05.018
  contributor:
    fullname: Paltrinieri S
– volume: 8
  start-page: S139
  year: 1986
  ident: ref25
  article-title: Immunologic diseases of foals
  publication-title: Comp. Cont. Educ. Pract
  contributor:
    fullname: Morris D.D
– start-page: 1857
  volume-title: Ruminant immunodeficiency diseases
  year: 1996
  ident: ref27
  contributor:
    fullname: Parish S.M
– year: 1997
  ident: ref15
  contributor:
    fullname: Kaneko J.J
– volume: 151
  start-page: 321
  year: 2011
  ident: ref19
  article-title: Changes in faecal bacteria and metabolic parameters in foals during the first six weeks of life
  publication-title: Vet. Microbiol
  doi: 10.1016/j.vetmic.2011.03.017
  contributor:
    fullname: Kuhl J
– volume: 38
  start-page: 693
  year: 1977
  ident: ref28
  article-title: Quantitation of bovine immunoglobulins: comparison of single radial immunodiffusion, zinc sulfate turbidity, serum electrophoresis, and refractometer methods
  publication-title: Am. J. Vet. Res
  contributor:
    fullname: Pfeiffer N.E
– year: 1990
  ident: ref18
  contributor:
    fullname: Koterba A.M
– volume: 52
  start-page: 1895
  year: 1969
  ident: ref3
  article-title: Bovine immunoglobulins: A review
  publication-title: J. Dairy Sci
  doi: 10.3168/jds.S0022-0302(69)86871-2
  contributor:
    fullname: Butler J.E
– volume: 29
  start-page: 486
  year: 2009
  ident: ref16
  article-title: Milk and serum immunoglobulin G concentrations in quarter horse mares and their foals
  publication-title: J. Eq. Vet. Sci
  doi: 10.1016/j.jevs.2009.04.177
  contributor:
    fullname: Kenzig A.R
– volume: 48
  start-page: 109
  issn: 0071-1276
  year: 1991
  ident: ref33
  article-title: Transferência de imunidade passiva em equinos: comportamento imunológico do recém-nascido
  publication-title: Anais ESALQ
  doi: 10.1590/S0071-12761991000100007
  contributor:
    fullname: Scotoni C.M.M
– start-page: 155
  volume-title: Neonatal syndromes: prematurity and dysmaturity
  year: 2004
  ident: ref17
  contributor:
    fullname: Knottenbelt D.C
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