Effect of a 5‐HT 2c receptor agonist on urethral closure mechanism in healthy women

• Published in: Neurourology and urodynamics Vol. 38; no. 6; pp. 1700 - 1706
• Main Authors: Klarskov, Niels, Van Till, Oliver, Sawyer, Will, Cernus, Dirk
• Format: Journal Article
• Language: English
• Published: United States 01.08.2019
• Subjects: Adolescent; Adult; Azepines - pharmacology; Azepines - therapeutic use; Cross-Over Studies; Duloxetine Hydrochloride - pharmacology; Duloxetine Hydrochloride - therapeutic use; Female; Healthy Volunteers; Humans; Middle Aged; Pressure; Quinolines - pharmacology; Quinolines - therapeutic use; Serotonin 5-HT2 Receptor Agonists - pharmacology; Serotonin 5-HT2 Receptor Agonists - therapeutic use; Treatment Outcome; Urethra - drug effects; Urinary Incontinence, Stress - drug therapy; Young Adult; serotonin receptor agonist; medical treatment; stress urinary incontinence; urethral pressure reflectometry

To evaluate the effect of ASP2205, a selective serotonin 5-HT receptor agonist, and Duloxetine on the urethral pressure in healthy female subjects. Healthy females aged 18 to 55 years were recruited for this phase 1, single site, placebo-controlled, randomized, four-period, cross-over study. The int...