Translational PK/PD and model-informed development of JNJ-67842125, a F ab reversal agent for JNJ-64179375, a long-acting thrombin inhibitor

• Published in: British journal of pharmacology Vol. 178; no. 19; pp. 3943 - 3958
• Main Authors: Ayyar, Vivaswath S, Jaiprasart, Pharavee, Geist, Brian, Huang Devine, Zheng, Case, Martin, Hazra, Anasuya, Hsu, Chyi-Hung, Chintala, Madhu, Wang, Weirong
• Format: Journal Article
• Language: English
• Published: England 01.10.2021
• Subjects: Antibodies (therapeutic); Pharmacodynamics; Mathematical modeling; Blood Pharmacology; Pharmacokinetics; Translational Pharmacology

Antigen-binding fragment (F ) reversal agents (RAs) were developed to reverse, in situations of bleeding emergency, the anticoagulant activity of JNJ-64179375 (JNJ-9375), a monoclonal antibody that specifically binds exosite-1 on thrombin and functions as a long-acting anticoagulant. The pharmacokin...