Translational PK/PD and model-informed development of JNJ-67842125, a F ab reversal agent for JNJ-64179375, a long-acting thrombin inhibitor
Antigen-binding fragment (F ) reversal agents (RAs) were developed to reverse, in situations of bleeding emergency, the anticoagulant activity of JNJ-64179375 (JNJ-9375), a monoclonal antibody that specifically binds exosite-1 on thrombin and functions as a long-acting anticoagulant. The pharmacokin...
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Published in | British journal of pharmacology Vol. 178; no. 19; pp. 3943 - 3958 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.10.2021
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Subjects | |
Online Access | Get full text |
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