The in vitro studies combined with molecular docking and MM-GBSA binding free energy calculations reveal broad-spectrum antibacterial activity of bacteriocin from curd-derived Limosilactobacillus fermentum with probiotic attributes

• Published in: In Silico Research in Biomedicine Vol. 1; p. 100009
• Main Authors: Halder, Debashis, Mandal, Shyamapada
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 2025
• Subjects: Antibacterial activity; Bacteriocin; Lactobacillus fermentum; MM-GBSA binding free energy; Molecular docking; Probiotic property; Antibacterial activity; Lactobacillus fermentum; Probiotic property; Molecular docking; MM-GBSA binding free energy; Bacteriocin

•Limosilactobacillus fermentum from cured showed favourable probiotic attributes•Bacteriocin from L. fermentum displayed broad-spectrum antibacterial properties•L. fermentum bacteriocin binds with virulence proteins sortase A and exotoxin A•MM-GBSA analysis conformed the stability of protein-bacteri...