Abstract 131: The role of p66ShcA in the melanoma oncogenesis process

• Published in: Cancer research (Chicago, Ill.) Vol. 82; no. 12_Supplement; p. 131
• Main Authors: Canedo, Eduardo Cepeda, Rincon, Sonia Del, Siegel, Peter, Witcher, Michael, Ursini-Siegel, Josie
• Format: Journal Article
• Language: English
• Published: 15.06.2022

Abstract Background: The identification of crucial driver mutations that affect the MAPK signaling pathway (BRAF, NRAS, NF1) in melanomas, has allowed for the development of targeted therapies and shed light on the process of melanocyte transformation. Gain of function mutations in proteins within t...