Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor

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Published inJournal of medicinal chemistry Vol. 65; no. 21; pp. 14614 - 14629
Main Authors Bröker, Joachim, Waterson, Alex G., Smethurst, Chris, Kessler, Dirk, Böttcher, Jark, Mayer, Moriz, Gmaschitz, Gerhard, Phan, Jason, Little, Andrew, Abbott, Jason R., Sun, Qi, Gmachl, Michael, Rudolph, Dorothea, Arnhof, Heribert, Rumpel, Klaus, Savarese, Fabio, Gerstberger, Thomas, Mischerikow, Nikolai, Treu, Matthias, Herdeis, Lorenz, Wunberg, Tobias, Gollner, Andreas, Weinstabl, Harald, Mantoulidis, Andreas, Krämer, Oliver, McConnell, Darryl B., W. Fesik, Stephen
Format Journal Article
LanguageEnglish
Published 10.11.2022
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Author Gerstberger, Thomas
Krämer, Oliver
Little, Andrew
Mantoulidis, Andreas
Savarese, Fabio
Böttcher, Jark
Gmaschitz, Gerhard
Gollner, Andreas
Mayer, Moriz
Treu, Matthias
Bröker, Joachim
Smethurst, Chris
Gmachl, Michael
Weinstabl, Harald
McConnell, Darryl B.
Wunberg, Tobias
W. Fesik, Stephen
Waterson, Alex G.
Rudolph, Dorothea
Abbott, Jason R.
Phan, Jason
Arnhof, Heribert
Mischerikow, Nikolai
Rumpel, Klaus
Kessler, Dirk
Sun, Qi
Herdeis, Lorenz
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Title Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor
Volume 65
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