Metabolite T 1 relaxation times decrease across the adult lifespan

• Published in: NMR in biomedicine Vol. 37; no. 9; p. e5152
• Main Authors: Murali‐Manohar, Saipavitra, Gudmundson, Aaron T., Hupfeld, Kathleen E., Zöllner, Helge J., Hui, Steve C. N., Song, Yulu, Simicic, Dunja, Davies‐Jenkins, Christopher W., Gong, Tao, Wang, Guangbin, Oeltzschner, Georg, Edden, Richard A. E.
• Format: Journal Article
• Language: English
• Published: England 01.09.2024
• Subjects: Adult; Aged; Aging - metabolism; Aging - physiology; Brain - diagnostic imaging; Brain - metabolism; Female; Humans; Longevity; Magnetic Resonance Spectroscopy; Male; Middle Aged; Young Adult; macromolecules; magnetic resonance spectroscopy; healthy aging; metabolites; T1 relaxation times

Relaxation correction is an integral step in quantifying brain metabolite concentrations measured by in vivo magnetic resonance spectroscopy (MRS). While most quantification routines assume constant T 1 relaxation across age, it is possible that aging alters T 1 relaxation rates, as is seen for T 2...