Oxygen chemoreceptor inhibition by dopamine D 2 receptors in isolated zebrafish gills

• Published in: The Journal of physiology Vol. 603; no. 8; pp. 2369 - 2385
• Main Authors: Reed, Maddison, Jonz, Michael G.
• Format: Journal Article
• Language: English
• Published: England 01.04.2025
• Subjects: Animals; Calcium - metabolism; Chemoreceptor Cells - drug effects; Chemoreceptor Cells - metabolism; Chemoreceptor Cells - physiology; Domperidone - pharmacology; Dopamine - metabolism; Dopamine Agonists - pharmacology; Dopamine D2 Receptor Antagonists - pharmacology; Gills - drug effects; Gills - metabolism; Gills - physiology; Hypoxia - metabolism; Neuroepithelial Cells - drug effects; Neuroepithelial Cells - metabolism; Neuroepithelial Cells - physiology; Oxygen - metabolism; Quinpirole - pharmacology; Receptors, Dopamine D2 - metabolism; Receptors, Dopamine D2 - physiology; Zebrafish; hypoxia; neuroepithelial cell; calcium; zebrafish; NEC; dopamine; D2; chemoreceptor

Dopamine is an essential modulator of oxygen sensing and control of ventilation and is the most well described and abundant neurotransmitter in the mammalian carotid body. Little is known of the evolutionary significance of dopamine in oxygen sensing, or whether it plays a similar role in anamniotes...