Dissociation of Drosophila Evi‐Wg Complex Occurs Post Apical Internalization in the Maturing Acidic Endosomes

• Published in: Traffic (Copenhagen, Denmark) Vol. 25; no. 9; p. e12955
• Main Authors: Sharma, Satyam, Chaudhary, Varun
• Format: Journal Article
• Language: English
• Published: Malden Wiley Subscription Services, Inc 01.09.2024
• Subjects: Cell surface; Drosophila; Endocytosis; Endosomes; Epithelium; Golgi apparatus; Insects; Internalization; Intracellular signalling; Membrane trafficking; Protein transport; Protein turnover; Secretion; Wnt protein

ABSTRACT Signaling pathways activated by secreted Wnt ligands play an essential role in tissue development and the progression of diseases, like cancer. Secretion of the lipid‐modified Wnt proteins is tightly regulated by a repertoire of intracellular factors. For instance, a membrane protein, Evi,...