Plasma Kallikrein Contributes to Ellagic Acid-Induced Coagulation in the Absence of FXI By Activating Factor IX

• Published in: Blood Vol. 134; no. Supplement_1; p. 1106
• Main Authors: Visser, Mayken, van Oerle, Rene, ten Cate, Hugo, Laux, Volker, Heitmeier, Stefan, Spronk, Henri M.H.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 13.11.2019

Background - Factor XI (FXI) plays a critical role in thrombosis, as its inhibition reduces clot formation in animal models, and human congenital FXI deficiency appears to protect against venous thromboembolism and stroke. In contrast, in both settings, the impact on hemostasis is rather low, especi...