Molecular Genetics of Fletcher and Fitzgerald Traits

• Published in: Blood Vol. 144; no. Supplement 1; p. 5504
• Main Authors: Adenaeuer, Anke, Pinheiro, Alessandro S., Shim, Young Jun, McCrae, Keith R., Häuser, Friederike, Lämmle, Bernhard, Schmaier, Alvin H., Rossmann, Heidi
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 05.11.2024

Deficiencies of the plasma protease zymogen prekallikrein (PK) and its substrate, high molecular weight kininogen (HK), were discovered in 1965 and 1975, respectively. Initially, they were referred to as Fletcher and Fitzgerald traits after the first patients identified. Shortly thereafter, other de...