Lyn Kinase Activity Is Required for Akt Mediated Erythroleukemia Cell Differentiation

• Published in: Blood Vol. 136; no. Supplement 1; p. 24
• Main Authors: Plani-LAM, Janice H.C., Maxwell, Mhairi, Slavova-Azmanova, Neli, Kucera, Nicole, Louw, Alison, Satiaputra, Jiulia, Wu, Susan, Bastow, Edward, Le, Cindy, Quilici, Cathy, Hibbs, Margaret L, Ingley, Evan
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 05.11.2020

Erythroleukemia (M6 subtype of Acute Myeloid Leukaemia) is uncommon but has a poor prognosis, with reports of successful differentiation therapy using erythropoietin (Epo). Signaling through the Epo-receptor, which involves JAK2 and Lyn tyrosine kinases, controls red blood cell progenitor developmen...