In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses

• Published in: Nature (London) Vol. 460; no. 7258; pp. 1021 - 1025
• Main Authors: Itoh, Yasushi, Shinya, Kyoko, Kiso, Maki, Watanabe, Tokiko, Sakoda, Yoshihiro, Hatta, Masato, Muramoto, Yukiko, Tamura, Daisuke, Sakai-Tagawa, Yuko, Noda, Takeshi, Sakabe, Saori, Imai, Masaki, Hatta, Yasuko, Watanabe, Shinji, Li, Chengjun, Yamada, Shinya, Fujii, Ken, Murakami, Shin, Imai, Hirotaka, Kakugawa, Satoshi, Ito, Mutsumi, Takano, Ryo, Iwatsuki-Horimoto, Kiyoko, Shimojima, Masayuki, Horimoto, Taisuke, Goto, Hideo, Takahashi, Kei, Makino, Akiko, Ishigaki, Hirohito, Nakayama, Misako, Okamatsu, Masatoshi, Takahashi, Kazuo, Warshauer, David, Shult, Peter A., Saito, Reiko, Suzuki, Hiroshi, Furuta, Yousuke, Yamashita, Makoto, Mitamura, Keiko, Nakano, Kunio, Nakamura, Morio, Brockman-Schneider, Rebecca, Mitamura, Hiroshi, Yamazaki, Masahiko, Sugaya, Norio, Suresh, M., Ozawa, Makoto, Neumann, Gabriele, Gern, James, Kida, Hiroshi, Ogasawara, Kazumasa, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.08.2009; Nature Publishing Group
• Subjects: Analysis; Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antibodies, Viral - immunology; Antiviral agents; Antiviral Agents - pharmacology; Avian flu; Biological and medical sciences; Cell Line; Cytokines; Dogs; Female; Ferrets - virology; Fundamental and applied biological sciences. Psychology; Genetic aspects; Global economy; HN Protein - metabolism; Humanities and Social Sciences; Humans; Identification and classification; Influenza; Influenza A virus; Influenza A Virus, H1N1 Subtype - drug effects; Influenza A Virus, H1N1 Subtype - enzymology; Influenza A Virus, H1N1 Subtype - pathogenicity; Influenza A Virus, H1N1 Subtype - physiology; Influenza viruses; letter; Lung - immunology; Lung - pathology; Lung - virology; Macaca fascicularis - immunology; Macaca fascicularis - virology; Male; Medical sciences; Mice; Mice, Inbred BALB C; Microbiology; multidisciplinary; Mustela; Neutralization Tests; Origin; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - transmission; Orthomyxoviridae Infections - virology; Pandemics; Pharmacology. Drug treatments; Primate Diseases - pathology; Primate Diseases - virology; Primates; Properties; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains; Risk assessment; Scanning electron microscopy; Science; Science (multidisciplinary); Swine; Swine - virology; Swine Diseases - pathology; Swine Diseases - virology; Swine flu; Swine influenza; Swine, Miniature - virology; Virology; Virus Replication; Viruses; Zoonoses; Japan; United States; Infection; In vivo; Sensitivity resistance; Pathogenesis; Viral disease; Animal; Antiviral; Influenza A; Replication; Pandemic; In vitro

Pandemic virus characterized Analysis of a series of clinical isolates of the swine-origin H1N1 influenza virus reveals that in mammalian models (mice, ferrets and macaques) the current pandemic virus is associated with more severe disease than a seasonal H1N1 strain. The viruses can also infect pig...