Naloxegol (Movantik®) Provides Rapid and Sustained Improvement of Opioid-Induced Constipation Symptoms Irrespective of Opioid Dose

• Published in: Pain management nursing Vol. 24; no. 2; p. 237
• Main Authors: McLeskey, Charles, Gudin, Jeffrey, Adler, Jeremy, Rockett, Carol, Jamindar, Mansi, Rauck, Richard, Webster, Lynn, Mallick-Searle, Theresa
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.04.2023

Naloxegol (Movantik), an oral peripherally acting mu-opioid receptor antagonist has demonstrated rapid relief of opioid-induced constipation (OIC) in patients with chronic non-cancer pain in two phase 3 trials (KODIAC 4/5; NCT01309841/NCT01323790). This analysis aims to characterize the OIC symptom...