High-Resolution Binding Atlas of U2AF1 Mutants Uncovers New Complexity in Splicing Alterations and Kinetics in Myeloid Malignancies

• Published in: Blood Vol. 136; no. Supplement 1; pp. 3 - 4
• Main Authors: Biancon, Giulia, Joshi, Poorval, Hunck, Torben, Zimmer, Josh, Gao, Yimeng, Machyna, Martin, Botti, Valentina, Qin, Ashley, Viero, Gabriella, Neuenkirchen, Nils, Taylor, Ashley, Gbyli, Rana, Patel, Amisha, Ardasheva, Anastasia, Fu, Xiaoying, Lin, Haifan, Simon, Matthew D, Neugebauer, Karla M, Tebaldi, Toma, Halene, Stephanie
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 05.11.2020

Spliceosomal gene mutations function as drivers of hematologic malignancies and other cancers with an occurrence of more than 50% in myelodysplastic syndromes and secondary acute myeloid leukemia. Hotspot mutations S34F and Q157R in the two zinc finger domains of the splicing factor U2AF1, forming w...