Harnessing Ferroptosis and Photothermal Effects: A New Paradigm in Aggressive Lymphoma Therapy

• Published in: Blood Vol. 144; no. Supplement 1; p. 2208
• Main Authors: Wang, Mengyao, Hu, Qian, Niu, Ting
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 05.11.2024

Background: Methotrexate (MTX) is a cornerstone drug in chemotherapy regimens for aggressive lymphomas. Recent studies have indicated that MTX promotes ferroptosis by inhibiting dihydrofolate reductase, thereby reducing the conversion of dihydrofolate to tetrahydrofolate (BH4) and disrupting the GCH...