Loss of METTL3 Mediated m6A RNA Modification Results in Double-Stranded RNA Induced Innate Immune Response and Hematopoietic Failure

• Published in: Blood Vol. 134; no. Supplement_1; p. 450
• Main Authors: Gao, Yimeng, Vasic, Radovan, Song, Yuanbin, Teng, Rhea, Gbyli, Rana, Biancon, Giulia, Nelakanti, Raman, Kudo, Eriko, Liu, Wei, Ardasheva, Anastasia, Fu, Xiaoying, Wang, Xiaman, Joshi, Poorval, Dura, Burak, Lee, Veronica, Viero, Gabriella, Iwasaki, Akiko, Fan, Rong, Xiao, Andrew, Flavell, Richard, Li, Hua-Bing, Tebaldi, Toma, Halene, Stephanie
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 13.11.2019

Hematopoietic stem cell (HSC) self-renewal and lineage output are orchestrated by multiple regulatory layers, including RNA modifications. N6-methyladenosine (m6A) is an abundant modification found in RNAs which affects the translation and stability of modified transcripts. The effects of m6A are de...