Concomitant Deletion of Short Arm (del 1p) and Amplification or Gain (1q21) of Chromosome 1 By Fluorescence in Situ Hybridization (FISH) Is Associated with Poor Clinical Outcome

• Published in: Blood Vol. 138; no. Supplement 1; p. 1627
• Main Authors: Mohan, Meera, Gong, Zimu, Kendrick, Samantha, Thanendrarajan, Sharmilan, Schinke, Carolina, Alapat, Daisy, Tricot, Guido, Zhan, Fenghuang, van Rhee, Frits, Sawyer, Jeffery R., Tian, Erming, Zangari, Maurizio
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 23.11.2021

Introduction- Chromosome 1 abnormalities in multiple myeloma (MM) are increasingly recognized as high risk defined features. While there is robust data on 1q21 gain and amplification (amp), the clinical characteristics and outcome of patients with del 1p is less defined. Novel agents are incorporate...