In Vivo reconstruction of Human Erythropoiesis with Circulating Mature Human RBCs in Humanized Liver Mistrg Mice

• Published in: Blood Vol. 134; no. Supplement_1; p. 338
• Main Authors: Song, Yuanbin, Shan, Liang, Gbyli, Rana, Liu, Wei, Fu, Xiaoying, Wang, Xiaman, Qin, Ashley, Patel, Amisha, Gao, Yimeng, Tebaldi, Toma, Biancon, Giulia, Urbonas, David, Alderman, Jonathan, Halene, Stephanie, Flavell, Richard
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 13.11.2019

The murine host has remained a readily available and ethically acceptable model for the study of human diseases and therapeutic testing. Immunodeficient mouse models support engraftment of human hematopoietic stem cells (HSC) but with limitation in efficiency and mature lineage representation. Combi...