Pre-Emptive Tyrosine Kinase-Inhibitor Intervention Based on BCR/ABL1 Monitoring in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia after Allo-HSCT: Two Independent Observational Cohort Study

• Published in: Blood Vol. 134; no. Supplement_1; p. 3303
• Main Authors: Hui, Liu, Xuan, Li, Lin, Ren, Deng, Lan, Huang, Fen, Fan, Zhiping, Nie, Danian, Li, Xudong, Liang, Xinquan, Xu, Dan, Zhang, Yu, Xu, Na, Ye, Jieyu, Jin, Hua, Lin, Dongjun, MA, Liping, Sun, Jing, Huang, Xiaojun, Liu, Qifa
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 13.11.2019

Relapse is a major cause of treatment-failure in persons with Philadelphia-chromosome-positive acute lymphoblastic leukemia (Ph+ALL) receiving an allogeneic hematopoietic cell transplant. There is controversy whether post-transplant tyrosine kinase-inhibitors (TKIs) reduces relapse risk. We evaluate...