Single Cell Genotype-Phenotype Analysis Demonstrates That Post-MPN AML Is Driven By Clonal Evolution and Loss of Transcriptional Heterogeneity within Stem Cell Compartments

• Published in: Blood Vol. 144; no. Supplement 1; p. 1346
• Main Authors: Straube, Jasmin, Grabek, Julian, Cooper, Leanne, Haldar, Rohit, McNamara, Caroline, Ross, David M, Perkins, Andrew, Bywater, Megan, Lane, Steven W
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 05.11.2024

Introduction Myeloproliferative neoplasms (MPN) are the consequence of acquired mutations in hematopoietic stem and progenitor cells (HSPCs). Specific mutations and mutational burden determine a patient's risk of disease progression to lethal post-MPN AML. Recent technological advancements link...