Age-dependent modulation of vascular niches for haematopoietic stem cells

• Published in: Nature (London) Vol. 532; no. 7599; pp. 380 - 384
• Main Authors: Kusumbe, Anjali P., Ramasamy, Saravana K., Itkin, Tomer, Mäe, Maarja Andaloussi, Langen, Urs H., Betsholtz, Christer, Lapidot, Tsvee, Adams, Ralf H.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.04.2016; Nature Publishing Group
• Subjects: 631/136/16; 631/532/1542; Aging; Aging - physiology; Animals; Arterioles - cytology; Arterioles - physiology; Bone and Bones - blood supply; Bone and Bones - cytology; Bone and Bones - metabolism; Bones; Capillaries - cytology; Capillaries - physiology; Cell Count; Cellular signal transduction; Endothelial Cells - metabolism; Endothelium; Gene expression; Growth; Hematopoietic stem cells; Hematopoietic Stem Cells - cytology; Humanities and Social Sciences; Hypoxia; Hypoxia-Inducible Factor 1 - metabolism; letter; Ligands; Male; Medicin och hälsovetenskap; Mice; Microenvironments; multidisciplinary; Observations; Osteogenesis; Physiological research; Platelet Endothelial Cell Adhesion Molecule-1 - metabolism; Platelet-derived growth factor; Properties; Receptor, Platelet-Derived Growth Factor beta - metabolism; Receptors, Notch - metabolism; Science; Signal Transduction; Skeletal system; Stem Cell Factor - metabolism; Stem Cell Niche; Stem cell research; Stem cells; Veins & arteries; Germany

Notch signalling in endothelial cells of the bone induces change in the capillaries and mesenchymal stem cells of the environment to support haematopoietic stem cell amplification. Age-linked changes in bone marrow Blood vessels in the bone marrow provide signals to the haematopoietic stem cells, ho...