Chronic inflammation in the etiology of disease across the life span

• Published in: Nature medicine Vol. 25; no. 12; pp. 1822 - 1832
• Main Authors: Furman, David, Campisi, Judith, Verdin, Eric, Carrera-Bastos, Pedro, Targ, Sasha, Franceschi, Claudio, Ferrucci, Luigi, Gilroy, Derek W., Fasano, Alessio, Miller, Gary W., Miller, Andrew H., Mantovani, Alberto, Weyand, Cornelia M., Barzilai, Nir, Goronzy, Jorg J., Rando, Thomas A., Effros, Rita B., Lucia, Alejandro, Kleinstreuer, Nicole, Slavich, George M.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.12.2019; Nature Publishing Group
• Subjects: 631/181/1403; 631/181/2474; 631/250/2520; 631/250/256; 692/699/67; Aging; Autoimmune Diseases - etiology; Autoimmune Diseases - physiopathology; Behavior; Biology; Biomedical and Life Sciences; Biomedicine; Cancer Research; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - etiology; Cardiovascular Diseases - physiopathology; Chronic Disease - epidemiology; Chronic diseases; Chronic infection; Cytokines; Diabetes; Diabetes mellitus; Diabetes Mellitus - etiology; Diabetes Mellitus - physiopathology; Environmental health; Etiology; Fatty liver; Health risk assessment; Health Sciences; Hospitals; Humans; Hälsovetenskap; Infections; Infectious Diseases; Inflammation; Inflammation - complications; Inflammation - epidemiology; Inflammation - physiopathology; Insulin resistance; Ischemia; Kidney diseases; Life span; Life Style; Liver diseases; Longevity - genetics; Longevity - physiology; Medical and Health Sciences; Medicin och hälsovetenskap; Medicine; Metabolic Diseases; Metabolic syndrome; Molecular Medicine; Mortality; Neoplasms - etiology; Neoplasms - physiopathology; Neurodegenerative diseases; Neurodegenerative Diseases - etiology; Neurodegenerative Diseases - physiopathology; Neurosciences; Non-alcoholic Fatty Liver Disease - etiology; Non-alcoholic Fatty Liver Disease - physiopathology; Pathogens; Patient outcomes; Perspective; Phenotypes; Psychological stress; Renal Insufficiency, Chronic - etiology; Renal Insufficiency, Chronic - physiopathology; Risk analysis; Risk Factors; Toxicants; United States

Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that colle...