New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

• Published in: Nature genetics Vol. 42; no. 2; pp. 105 - 116
• Main Authors: Jackson, Anne U, Wheeler, Eleanor, Bouatia-Naji, Nabila, Morris, Andrew P, Rybin, Denis, Thorleifsson, Gudmar, Steinthorsdottir, Valgerdur, Grallert, Harald, Dehghan, Abbas, Franklin, Christopher S, Song, Kijoung, Egan, Josephine M, Lajunen, Taina, Doney, Alex, Kanoni, Stavroula, Qi, Lu, Gieger, Christian, Payne, Felicity, Roccasecca, Rosa Maria, Sethupathy, Praveen, Balkau, Beverley, Barter, Philip, Beilby, John P, Benediktsson, Rafn, Bergmann, Sven, Bumpstead, Suzannah J, Chines, Peter, Cornelis, Marilyn, Day, Ian N M, de Geus, Eco J C, Dina, Christian, Erdos, Michael R, Fedson, Annette C, Fischer-Rosinsky, Antje, Graessler, Jürgen, Grundy, Scott, Hartikainen, Anna-Liisa, Hassanali, Neelam, Hayward, Caroline, Heath, Simon C, Herder, Christian, Hicks, Andrew A, Hillman, David R, Hingorani, Aroon D, Hui, Jennie, Isomaa, Bo, Johnson, Paul R V, Jula, Antti, Kaakinen, Marika, Kesaniemi, Y Antero, Kivimaki, Mika, Knight, Beatrice, Mahley, Robert, Mangino, Massimo, McAteer, Jarred B, McPherson, Ruth, Morken, Mario A, Mukherjee, Sutapa, Naitza, Silvia, Narisu, Narisu, Pattaro, Cristian, Pedersen, Nancy L, Pichler, Irene, Polasek, Ozren, Posthuma, Danielle, Province, Michael A, Psaty, Bruce M, Roden, Michael, Sanna, Serena, Sayer, Avan Aihie, Scheet, Paul, Scott, Laura J, Seedorf, Udo, Shields, Beverley, Simpson, Laila, Swift, Amy, Syvänen, Ann-Christine, Tanaka, Toshiko, Thorand, Barbara, Tichet, Jean, Varma, Dhiraj, Vitart, Veronique, Waeber, Gérard, Walley, Andrew, Walters, G Bragi, Wild, Sarah H, Zelenika, Diana, Zhai, Guangju, Zillikens, M Carola, Meneton, Pierre, Magnusson, Patrik K E, Salomaa, Veikko, Schwarz, Peter, Karpe, Fredrik, Dedoussis, George V, Kuusisto, Johanna, Pedersen, Oluf, Pramstaller, Peter Paul, Wichmann, H Erich, Stumvoll, Michael
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.02.2010; Nature Publishing Group
• Subjects: 631/208/727/2000; 631/208/729/743; 631/443/319/1642/137/773; Adolescent; Adult; Agriculture; Alleles; Animal Genetics and Genomics; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Blood Glucose - genetics; Blood Glucose - metabolism; Cancer Research; Child; Clinical Medicine; Databases, Genetic; Delta-5 Fatty Acid Desaturase; Diabetes; Diabetes Mellitus, Type 2 - genetics; Diabetes. Impaired glucose tolerance; DNA Copy Number Variations - genetics; Endocrine pancreas. Apud cells (diseases); Endocrinology and Diabetes; Endocrinopathies; Endokrinologi och diabetes; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Fasting - blood; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation; Gene Function; Genetic aspects; Genetic Loci - genetics; Genetic Predisposition to Disease; Genetics of eukaryotes. Biological and molecular evolution; Genome-Wide Association Study; Glucose; Health aspects; Health risks; Homeostasis; Homeostasis - genetics; Human Genetics; Humans; Hyperglycemia; Insulin; Klinisk medicin; Life Sciences; Medical and Health Sciences; Medical sciences; MEDICIN; Medicin och hälsovetenskap; MEDICINE; Meta-analysis; Meta-Analysis as Topic; Physiological aspects; Polymorphism, Single Nucleotide - genetics; Quantitative Trait Loci - genetics; Quantitative Trait, Heritable; Reproducibility of Results; Risk factors; Sample size; Studies; Type 2 diabetes; United Kingdom; Netherlands; Sweden; Endocrinopathy; Type 2 diabetes; Homeostasis; Metabolic diseases; Genetics; Risk; Glucose; Locus
• ISSN: 1061-4036; 1546-1718; 1546-1718
• DOI: 10.1038/ng.520

The MAGIC investigators report results of a large genome-wide association study meta-analysis to identify common variants influencing fasting glucose homeostasis. They further show that several of the newly discovered loci influencing glycemic traits are also associated with risk of type 2 diabetes....