Abstract 15325: Dynamic Change From Mitochondrial Compensation to Mitochondrial Failure During Aortic Disease Progression and Dissection Formation

• Published in: Circulation (New York, N.Y.) Vol. 146; no. Suppl_1; p. A15325
• Main Authors: Li, Yanming, Zhou, Zhen, Zhang, Chen, Vasquez, Hernan, Li, Yang, Chakraborty, Abhijit, Rebello, Kimberly, Zhang, Lin, Ren, Pingping, Azares, Alon R, Chen, Rui, li, yumei, Lu, Hong S, Cassis, Lisa A, Coselli, Joseph S, Daugherty, Alan, LeMaire, Scott A, Milewicz, Dianna M, Shen, Ying H
• Format: Journal Article
• Language: English
• Published: Lippincott Williams & Wilkins 08.11.2022

IntroductionAscending thoracic aortic aneurysm (ATAA) progression to dissection (ATAD) is associated with a high risk of mortality. Since the specific molecular and cellular changes leading to dissection are poorly understood, we compared transcriptome profiles of aortic smooth muscle cells (SMCs) b...