Abstract 12186: Therapeutic Effects of Blockade of IL-6/gp130 Signaling in Pulmonary Arterial Hypertension

• Published in: Circulation (New York, N.Y.) Vol. 132; no. Suppl_3 Suppl 3; p. A12186
• Main Authors: Tamura, Yuichi, Phan, Carole, Tu, Ly, Thuillet, Raphaël, Le Hiress, Morane, Huertas, Alice, Fadel, Elie, Simonneau, Gerald, Humbert, Marc, Guignabert, Christophe
• Format: Journal Article
• Language: English
• Published: by the American College of Cardiology Foundation and the American Heart Association, Inc 10.11.2015

BackgroundInterleukin (IL)-6 has been linked to the prognosis of pulmonary arterial hypertension (PAH). However, precise contributions of IL-6 and its signaling system to PAH progression is still obscure.ObjectivesTo study pathogenic roles of IL-6 cis- and trans-signaling in experimental and human P...