The genetic architecture of type 2 diabetes

• Published in: Nature (London) Vol. 536; no. 7614; pp. 41 - 47
• Main Authors: Gaulton, Kyle J., McCarthy, Davis J., Sim, Xueling, Rayner, N. William, Cingolani, Pablo, Hartl, Christopher, Pearson, Richard D., Grarup, Niels, Chen, Yuhui, Chen, Peng, Go, Min Jin, Parker, Stephen C. J., Varga, Tibor V., Hu, Cheng, Kim, Bong-Jo, Kim, Yongkang, Kim, Young Jin, Maxwell, Taylor J., Nagai, Yoshihiko, Zhang, Weihua, Barzilai, Nir, Han, Bok-Ghee, Stančáková, Alena, Abboud, Hanna E., Boeing, Heiner, Prabhakaran, Dorairaj, Butterworth, Adam S., Lee, Heung Man, Kwak, Soo-Heon, Zhao, Wei, So, Wing Yee, Cheng, Ching-Yu, Curran, Joanne E., Freedman, Barry I., Kumar, Satish, van der Schouw, Yvonne T., Loh, Marie, Musani, Solomon K., Tan, Sian-Tsung, Taylor Jr, Herman A., Levy, Jonathan C., Mangino, Massimo, Bonnycastle, Lori L., Fadista, João, Surdulescu, Gabriela L., Herder, Christian, Groves, Christopher J., Brandslund, Ivan, Lyssenko, Valeriya, Hollensted, Mette, Jørgensen, Marit E., Ladenvall, Claes, Justesen, Johanne Marie, Linneberg, Allan, Qi, Qibin, Roden, Michael, Wood, Andrew R., Mihailov, Evelin, Maguire, Jared, Poplin, Ryan, Shakir, Khalid, Hrabé de Angelis, Martin, Jun, Goo, Murphy, Jacquelyn, Onofrio, Robert, Thorand, Barbara, Meisinger, Christa, Hu, Frank B., Peters, Annette, Rauramaa, Rainer, Salomaa, Veikko, Watanabe, Richard M., Bergman, Richard N., Bharadwaj, Dwaipayan, Chia, Kee Seng, Langenberg, Claudia, Elliott, Paul, Jablonski, Kathleen A., Ma, Ronald C. W., Tandon, Nikhil, Barroso, Inês, Zeggini, Eleftheria, Ried, Janina S., DeFronzo, Ralph A., Grallert, Harald, Banks, Eric, Trakalo, Joseph, Lind, Lars, Farjoun, Yossi, Owen, Katharine R., Gloyn, Anna L., Kooner, Jaspal Singh, Bowden, Donald W., Collins, Francis S., Atzmon, Gil, Hanis, Craig L., Seielstad, Mark, Frayling, Timothy M., Scott, Laura J., Altshuler, David
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.08.2016; Nature Publishing Group
• Subjects: 45/23; 45/43; 631/208/205/2138; 631/208/514/2254; 631/208/726/649/2219; 692/699/2743/137; allele; Alleles; Analysis; ancestry; Clinical Medicine; controlled study; Diabetes; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - genetics; DNA Mutational Analysis; DNA sequencing; Endocrinology and Diabetes; Endokrinologi och diabetes; ethnology; Europe; Europe - ethnology; European; Exome; gene sequence; Genes; genetic analysis; genetic code; genetic predisposition; Genetic Predisposition to Disease; Genetic Predisposition to Disease - genetics; genetic structure; genetic variation; Genetic Variation - genetics; Genetics; genome; Genome-Wide Association Study; Genomes; Genomic structural variations; genotype; genotyping technique; Genotyping Techniques; health risk; Health risk assessment; human; Humanities and Social Sciences; Humans; Klinisk medicin; major clinical study; Medical and Health Sciences; Medicin och hälsovetenskap; multidisciplinary; non insulin dependent diabetes mellitus; Nucleotide sequencing; pathology; physiology; priority journal; Sample Size; Science; Studies; Type 2 diabetes; Europe

The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, t...