An Arabidopsis SUMO E3 Ligase, SIZ1, Negatively Regulates Photomorphogenesis by Promoting COP1 Activity

• Published in: PLOS genetics Vol. 12; no. 4; p. e1006016
• Main Authors: 三浦 謙治, Lin Xiao-Li, Niu De, Hu Zi-Liang, Kim Dae Heon, Jin Yin Hua, Cai Bin, Liu Peng, Miura Kenji, Yun Dae-Jin, Kim Woe-Yeon, Lin Rongcheng, Jin Jing Bo
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2016; Public Library of Science (PLoS)
• Subjects: Amino Acid Substitution - genetics; Amino acids; Arabidopsis; Arabidopsis - genetics; Arabidopsis - growth & development; Arabidopsis Proteins - genetics; Arabidopsis Proteins - metabolism; Arabidopsis thaliana; Basic-Leucine Zipper Transcription Factors - genetics; Basic-Leucine Zipper Transcription Factors - metabolism; Biology and life sciences; Cell cycle; Gene Expression Regulation, Plant; Genetic aspects; Genetic research; Homeostasis; Kinases; Ligases; Ligases - genetics; Ligases - metabolism; Light; Mutation; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Photomorphogenesis; Physiological aspects; Plant Development - genetics; Post-translational modifications; Proteins; Proteolysis; Research and Analysis Methods; Seedlings - genetics; Seedlings - growth & development; Small Ubiquitin-Related Modifier Proteins - genetics; Small Ubiquitin-Related Modifier Proteins - metabolism; Sumoylation - genetics; Ubiquitin; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Ubiquitination - genetics

COP1 (CONSTITUTIVE PHOTOMORPHOGENIC 1), a ubiquitin E3 ligase, is a central negative regulator of photomorphogenesis. However, how COP1 activity is regulated by post-translational modifications remains largely unknown. Here we show that SUMO (small ubiquitin-like modifier) modification enhances COP1...