Human subtelomeric WASH genes encode a new subclass of the WASP family

• Published in: PLoS genetics Vol. 3; no. 12; p. e237
• Main Authors: Linardopoulou, Elena V, Parghi, Sean S, Friedman, Cynthia, Osborn, Gregory E, Parkhurst, Susan M, Trask, Barbara J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.12.2007; Public Library of Science (PLoS)
• Subjects: Actin-Related Protein 2-3 Complex - metabolism; Actins - metabolism; Amino Acid Sequence; Animals; Biology; Caenorhabditis; Cell Biology; Chromosomes; Chromosomes, Human - genetics; Computational Biology; Conserved Sequence; Deoxyribonucleic acid; Developmental Biology; DNA; Drosophila; Drosophila - genetics; Drosophila - metabolism; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Entamoeba; Evolution, Molecular; Evolutionary Biology; Experiments; Gene Duplication; Gene Expression; Genes; Genes, Insect; Genetic Variation; Genetics; Genetics and Genomics; Genomes; Human; Humans; In Situ Hybridization, Fluorescence; Infectious Diseases; Insects; Molecular Biology; Molecular Sequence Data; Multigene Family; Mutation; Open Reading Frames; Pan troglodytes; Phylogeny; Primates; Primates - genetics; Proteins; Sequence Homology, Amino Acid; Signal transduction; Telomerase; Telomere - genetics; Wiskott-Aldrich Syndrome Protein Family - classification; Wiskott-Aldrich Syndrome Protein Family - genetics; Wiskott-Aldrich Syndrome Protein Family - metabolism

Subtelomeres are duplication-rich, structurally variable regions of the human genome situated just proximal of telomeres. We report here that the most terminally located human subtelomeric genes encode a previously unrecognized third subclass of the Wiskott-Aldrich Syndrome Protein family, whose kno...