Multiple molecular mechanisms for multidrug resistance transporters

• Published in: Nature Vol. 446; no. 7137; pp. 749 - 757
• Main Author: Higgins, Christopher F
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.04.2007; Nature Publishing; Nature Publishing Group
• Subjects: Animals; Antibacterial agents; Antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiparasitic agents; ATP-Binding Cassette Transporters - chemistry; ATP-Binding Cassette Transporters - metabolism; Biochemistry; Biological and medical sciences; Biomedical research; Chemical compounds; Drug resistance; Drug Resistance, Multiple - physiology; Glycoprotein; Health care; Herbicides; Human; Humanities and Social Sciences; Humans; Mammals; Marketing; Medical sciences; Molecular biology; multidisciplinary; Multidrug Resistance-Associated Proteins - chemistry; Multidrug Resistance-Associated Proteins - metabolism; Organisms; Pharmacology. Drug treatments; Protein Conformation; Proteins; Pumps; review-article; Science; Science (multidisciplinary); Structure-Activity Relationship; Transcription Factors - metabolism; Antineoplastic agent; Antimalarial; Antibiotic; Three dimensional structure; Molecular structure; Multiple resistance; Pesticides; P Glycoprotein; Parasiticide; Mechanism of action; ABC transporter; Herbicide

The acquisition of multidrug resistance is a serious impediment to improved healthcare. Multidrug resistance is most frequently due to active transporters that pump a broad spectrum of chemically distinct, cytotoxic molecules out of cells, including antibiotics, antimalarials, herbicides and cancer...