Genetic Variation at a Yin-Yang 1 Response Site Regulates the Transcription of Cyclin-Dependent Kinase Inhibitor p18 INK4C Transcript in Lupus-Prone Mice

• Published in: The Journal of immunology (1950) Vol. 188; no. 10; pp. 4992 - 5002
• Main Authors: Potula, Hari-Hara S. K., Morel, Laurence
• Format: Journal Article
• Language: English
• Published: 15.05.2012

Abstract We have previously shown that a novel −74 C-to-T mutation in the promoter of the cyclin-dependent kinase inhibitor p18Ink4c (p18) gene was associated with a reduced p18 expression in B cells from mice carrying the Sle2c1 lupus susceptibility locus. To determine the function of the −74 C/T s...