Genetic Variation at a Yin-Yang 1 Response Site Regulates the Transcription of Cyclin-Dependent Kinase Inhibitor p18 INK4C Transcript in Lupus-Prone Mice
Abstract We have previously shown that a novel −74 C-to-T mutation in the promoter of the cyclin-dependent kinase inhibitor p18Ink4c (p18) gene was associated with a reduced p18 expression in B cells from mice carrying the Sle2c1 lupus susceptibility locus. To determine the function of the −74 C/T s...
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Published in | The Journal of immunology (1950) Vol. 188; no. 10; pp. 4992 - 5002 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
15.05.2012
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Online Access | Get full text |
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