Abstract 72: Genetic variance in heparan sulfation is associated with salt-sensitivity: a gene-environment analysis in EPIC-Norfolk, UK biobank, and HELIUS

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 81; no. Suppl_1; p. A72
• Main Authors: Oppelaar, Jetta, Romman, Mohamed, Sahebdin, Ghazalah, Zwinderman, Aeilko, Galenkamp, Henrike, Boekholdt, S, Van den Born, Bert-Jan, Olde Engberink, Rik, Vogt, Liffert
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.09.2024
• Subjects: Hypertension; Intervention; Diet; Genes, environment, and lifestyle interactions

Background: High heritability of salt sensitivity suggests an essential role for genetics in the relationship between sodium intake and blood pressure (BP). The role of glycosaminoglycan (GAG) genes, which are crucial for salinity tolerance througout evolution, remains to be elucidated. Methods: Int...