lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs
A study of prostate cancer cells reveals a transcriptional activation role for long non-coding RNAs (PRNCR1 and PCGEM1) that bind to the androgen receptor, and is also observed for the truncated androgen receptor characteristic of many aggressive prostate cancers. Cancer growth influenced by long no...
Saved in:
Published in | Nature (London) Vol. 500; no. 7464; pp. 598 - 602 |
---|---|
Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
29.08.2013
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | A study of prostate cancer cells reveals a transcriptional activation role for long non-coding RNAs (PRNCR1 and PCGEM1) that bind to the androgen receptor, and is also observed for the truncated androgen receptor characteristic of many aggressive prostate cancers.
Cancer growth influenced by long non-coding RNAs
Several long non-coding RNAs (lncRNAs) are known to be overexpressed in prostate cancer. Michael Rosenfeld and colleagues have investigated the mechanistic and biological roles of two of these, known as PRNCR1 and PCGEM1. Both are found to interact with the androgen receptor (AR) dependent on specific post-translational modifications, and to enhance the looping of AR-bound enhancers to target gene promoters, leading to enhanced gene expression. They also enhance AR-mediated proliferation in prostate cancer cells and are required for tumour growth in a prostate cancer xenograft mouse model. PRNCR1 and PCGEM1 are upregulated in castration-resistant prostate cancer cell lines. The regulatory roles of lncRNAs in prostate cancer uncovered in this manuscript may open the way to new therapeutic approaches.
Although recent studies have indicated roles of long non-coding RNAs (lncRNAs) in physiological aspects of cell-type determination and tissue homeostasis
1
, their potential involvement in regulated gene transcription programs remains rather poorly understood. The androgen receptor regulates a large repertoire of genes central to the identity and behaviour of prostate cancer cells
2
, and functions in a ligand-independent fashion in many prostate cancers when they become hormone refractory after initial androgen deprivation therapy
3
. Here we report that two lncRNAs highly overexpressed in aggressive prostate cancer, PRNCR1 (also known as PCAT8) and PCGEM1, bind successively to the androgen receptor and strongly enhance both ligand-dependent and ligand-independent androgen-receptor-mediated gene activation programs and proliferation in prostate cancer cells. Binding of PRNCR1 to the carboxy-terminally acetylated androgen receptor on enhancers and its association with DOT1L appear to be required for recruitment of the second lncRNA, PCGEM1, to the androgen receptor amino terminus that is methylated by DOT1L. Unexpectedly, recognition of specific protein marks by PCGEM1-recruited pygopus 2 PHD domain enhances selective looping of androgen-receptor-bound enhancers to target gene promoters in these cells. In ‘resistant’ prostate cancer cells, these overexpressed lncRNAs can interact with, and are required for, the robust activation of both truncated and full-length androgen receptor, causing ligand-independent activation of the androgen receptor transcriptional program and cell proliferation. Conditionally expressed short hairpin RNA targeting these lncRNAs in castration-resistant prostate cancer cell lines strongly suppressed tumour xenograft growth
in vivo
. Together, these results indicate that these overexpressed lncRNAs can potentially serve as a required component of castration-resistance in prostatic tumours. |
---|---|
AbstractList | While recent studies indicated roles of long non-coding RNAs (lncRNAs) in physiologic aspects of cell-type determination and tissue homeostasis
1
yet their potential involvement in regulated gene transcription programs remain rather poorly understood. Androgen receptor (AR) regulates a large repertoire of genes central to the identity and behavior of prostate cancer cells
2
, and functions in a ligand-independent fashion in many prostate cancers when they become hormone refractory after initial androgen deprivation therapy
3
. Here, we report that two lncRNAs highly overexpressed in aggressive prostate cancer,
PRNCR1
and
PCGEM1
, bind successively to the AR and strongly enhance both ligand-dependent and ligand-independent AR-mediated gene activation programs and proliferation in prostate cancer cells. Binding of
PRNCR1
to the C-terminally acetylated AR on enhancers and its association with DOT1L appear to be required for recruitment of the second lncRNA,
PCGEM1
, to the DOT1L-mediated methylated AR N-terminus. Unexpectedly, recognition of specific protein marks by
PCGEM1
-recruited Pygopus2 PHD domain proves to enhance selective looping of AR-bound enhancers to target gene promoters in these cells. In “resistant” prostate cancer cells, these overexpressed lncRNAs can interact with, and are required for, the robust activation of both truncated and full length AR, causing ligand-independent activation of the AR transcriptional program and cell proliferation. Conditionally-expressed short hairpin RNA (shRNA) targeting of these lncRNAs in castration-resistant prostate cancer (CRPC) cell lines strongly suppressed tumor xenograft growth
in vivo
. Together, these results suggest that these overexpressed lncRNAs can potentially serve as a required component of castration-resistance in prostatic tumors. A study of prostate cancer cells reveals a transcriptional activation role for long non-coding RNAs (PRNCR1 and PCGEM1) that bind to the androgen receptor, and is also observed for the truncated androgen receptor characteristic of many aggressive prostate cancers. A study of prostate cancer cells reveals a transcriptional activation role for long non-coding RNAs (PRNCR1 and PCGEM1) that bind to the androgen receptor, and is also observed for the truncated androgen receptor characteristic of many aggressive prostate cancers. Cancer growth influenced by long non-coding RNAs Several long non-coding RNAs (lncRNAs) are known to be overexpressed in prostate cancer. Michael Rosenfeld and colleagues have investigated the mechanistic and biological roles of two of these, known as PRNCR1 and PCGEM1. Both are found to interact with the androgen receptor (AR) dependent on specific post-translational modifications, and to enhance the looping of AR-bound enhancers to target gene promoters, leading to enhanced gene expression. They also enhance AR-mediated proliferation in prostate cancer cells and are required for tumour growth in a prostate cancer xenograft mouse model. PRNCR1 and PCGEM1 are upregulated in castration-resistant prostate cancer cell lines. The regulatory roles of lncRNAs in prostate cancer uncovered in this manuscript may open the way to new therapeutic approaches. Although recent studies have indicated roles of long non-coding RNAs (lncRNAs) in physiological aspects of cell-type determination and tissue homeostasis.sup.1, their potential involvement in regulated gene transcription programs remains rather poorly understood. The androgen receptor regulates a large repertoire of genes central to the identity and behaviour of prostate cancer cells.sup.2, and functions in a ligand-independent fashion in many prostate cancers when they become hormone refractory after initial androgen deprivation therapy.sup.3. Here we report that two lncRNAs highly overexpressed in aggressive prostate cancer, PRNCR1 (also known as PCAT8) and PCGEM1, bind successively to the androgen receptor and strongly enhance both ligand-dependent and ligand-independent androgen-receptor-mediated gene activation programs and proliferation in prostate cancer cells. Binding of PRNCR1 to the carboxy-terminally acetylated androgen receptor on enhancers and its association with DOT1L appear to be required for recruitment of the second lncRNA, PCGEM1, to the androgen receptor amino terminus that is methylated by DOT1L. Unexpectedly, recognition of specific protein marks by PCGEM1-recruited pygopus 2 PHD domain enhances selective looping of androgen-receptor-bound enhancers to target gene promoters in these cells. In 'resistant' prostate cancer cells, these overexpressed lncRNAs can interact with, and are required for, the robust activation of both truncated and full-length androgen receptor, causing ligand-independent activation of the androgen receptor transcriptional program and cell proliferation. Conditionally expressed short hairpin RNA targeting these lncRNAs in castration-resistant prostate cancer cell lines strongly suppressed tumour xenograft growth in vivo. Together, these results indicate that these overexpressed lncRNAs can potentially serve as a required component of castration-resistance in prostatic tumours. Although recent studies have indicated roles of long non-coding RNAs (lncRNAs) in physiological aspects of cell-type determination and tissue homeostasis, their potential involvement in regulated gene transcription programs remains rather poorly understood. The androgen receptor regulates a large repertoire of genes central to the identity and behaviour of prostate cancer cells, and functions in a ligand-independent fashion in many prostate cancers when they become hormone refractory after initial androgen deprivation therapy. Here we report that two lncRNAs highly overexpressed in aggressive prostate cancer, PRNCR1 (also known as PCAT8) and PCGEM1, bind successively to the androgen receptor and strongly enhance both ligand-dependent and ligand-independent androgen-receptor-mediated gene activation programs and proliferation in prostate cancer cells. Binding of PRNCR1 to the carboxy-terminally acetylated androgen receptor on enhancers and its association with DOT1L appear to be required for recruitment of the second lncRNA, PCGEM1, to the androgen receptor amino terminus that is methylated by DOT1L. Unexpectedly, recognition of specific protein marks by PCGEM1-recruited pygopus 2 PHD domain enhances selective looping of androgen-receptor-bound enhancers to target gene promoters in these cells. In 'resistant' prostate cancer cells, these overexpressed lncRNAs can interact with, and are required for, the robust activation of both truncated and full-length androgen receptor, causing ligand-independent activation of the androgen receptor transcriptional program and cell proliferation. Conditionally expressed short hairpin RNA targeting these lncRNAs in castration-resistant prostate cancer cell lines strongly suppressed tumour xenograft growth in vivo. Together, these results indicate that these overexpressed lncRNAs can potentially serve as a required component of castration-resistance in prostatic tumours. Although recent studies have indicated roles of long non-coding RNAs (lncRNAs) in physiological aspects of cell-type determination and tissue homeostasis, their potential involvement in regulated gene transcription programs remains rather poorly understood. The androgen receptor regulates a large repertoire of genes central to the identity and behaviour of prostate cancer cells, and functions in a ligand-independent fashion in many prostate cancers when they become hormone refractory after initial androgen deprivation therapy. Here we report that two lncRNAs highly overexpressed in aggressive prostate cancer, PRNCR1 (also known as PCAT8) and PCGEM1, bind successively to the androgen receptor and strongly enhance both ligand-dependent and ligand-independent androgen-receptor-mediated gene activation programs and proliferation in prostate cancer cells. Binding of PRNCR1 to the carboxy-terminally acetylated androgen receptor on enhancers and its association with DOT1L appear to be required for recruitment of the second lncRNA, PCGEM1, to the androgen receptor amino terminus that is methylated by DOT1L. Unexpectedly, recognition of specific protein marks by PCGEM1- recruited pygopus 2 PHD domain enhances selective looping of androgen-receptor-bound enhancers to target gene promoters in these cells. In 'resistant' prostate cancer cells, these overexpressed lncRNAs can interact with, and are required for, the robust activation of both truncated and full-length androgen receptor, causing ligand-independent activation of the androgen receptor transcriptional programand cell proliferation.Conditionally expressed short hairpin RNA targeting these lncRNAs in castration-resistant prostate cancer cell lines strongly suppressed tumour xenograftgrowth in vivo. Together, these results indicate that these overexpressed lncRNAs can potentially serve as a required component of castration-resistance in prostatic tumours. [PUBLICATION ABSTRACT] A study of prostate cancer cells reveals a transcriptional activation role for long non-coding RNAs (PRNCR1 and PCGEM1) that bind to the androgen receptor, and is also observed for the truncated androgen receptor characteristic of many aggressive prostate cancers. Cancer growth influenced by long non-coding RNAs Several long non-coding RNAs (lncRNAs) are known to be overexpressed in prostate cancer. Michael Rosenfeld and colleagues have investigated the mechanistic and biological roles of two of these, known as PRNCR1 and PCGEM1. Both are found to interact with the androgen receptor (AR) dependent on specific post-translational modifications, and to enhance the looping of AR-bound enhancers to target gene promoters, leading to enhanced gene expression. They also enhance AR-mediated proliferation in prostate cancer cells and are required for tumour growth in a prostate cancer xenograft mouse model. PRNCR1 and PCGEM1 are upregulated in castration-resistant prostate cancer cell lines. The regulatory roles of lncRNAs in prostate cancer uncovered in this manuscript may open the way to new therapeutic approaches. Although recent studies have indicated roles of long non-coding RNAs (lncRNAs) in physiological aspects of cell-type determination and tissue homeostasis 1 , their potential involvement in regulated gene transcription programs remains rather poorly understood. The androgen receptor regulates a large repertoire of genes central to the identity and behaviour of prostate cancer cells 2 , and functions in a ligand-independent fashion in many prostate cancers when they become hormone refractory after initial androgen deprivation therapy 3 . Here we report that two lncRNAs highly overexpressed in aggressive prostate cancer, PRNCR1 (also known as PCAT8) and PCGEM1, bind successively to the androgen receptor and strongly enhance both ligand-dependent and ligand-independent androgen-receptor-mediated gene activation programs and proliferation in prostate cancer cells. Binding of PRNCR1 to the carboxy-terminally acetylated androgen receptor on enhancers and its association with DOT1L appear to be required for recruitment of the second lncRNA, PCGEM1, to the androgen receptor amino terminus that is methylated by DOT1L. Unexpectedly, recognition of specific protein marks by PCGEM1-recruited pygopus 2 PHD domain enhances selective looping of androgen-receptor-bound enhancers to target gene promoters in these cells. In ‘resistant’ prostate cancer cells, these overexpressed lncRNAs can interact with, and are required for, the robust activation of both truncated and full-length androgen receptor, causing ligand-independent activation of the androgen receptor transcriptional program and cell proliferation. Conditionally expressed short hairpin RNA targeting these lncRNAs in castration-resistant prostate cancer cell lines strongly suppressed tumour xenograft growth in vivo . Together, these results indicate that these overexpressed lncRNAs can potentially serve as a required component of castration-resistance in prostatic tumours. |
Audience | Academic |
Author | Merkurjev, Daria Ohgi, Kenneth A. Tanasa, Bogdan Rosenfeld, Michael G. Meng, Da Evans, Christopher P. Yang, Liuqing Lin, Chunru Yang, Joy C. Zhang, Jie Jin, Chunyu Li, Wenbo |
AuthorAffiliation | 6 Neurosciences Graduate Program, Department of Biological Sciences, University of California San Diego, La Jolla 92093, USA 5 Bioinformatics and System Biology Program, Department of Bioengineering, University of California San Diego, La Jolla 92093, USA 4 Graduate Program, Kellogg School of Science and Technology, The Scripps Research Institute, La Jolla 92037, USA 2 Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA 1 Howard Hughes Medical Institute, Department of Medicine, University of California San Diego, La Jolla 92093, USA 3 Department of Urology, School of Medicine, University of California Davis, Sacramento 95817, USA |
AuthorAffiliation_xml | – name: 5 Bioinformatics and System Biology Program, Department of Bioengineering, University of California San Diego, La Jolla 92093, USA – name: 2 Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA – name: 1 Howard Hughes Medical Institute, Department of Medicine, University of California San Diego, La Jolla 92093, USA – name: 6 Neurosciences Graduate Program, Department of Biological Sciences, University of California San Diego, La Jolla 92093, USA – name: 3 Department of Urology, School of Medicine, University of California Davis, Sacramento 95817, USA – name: 4 Graduate Program, Kellogg School of Science and Technology, The Scripps Research Institute, La Jolla 92037, USA |
Author_xml | – sequence: 1 givenname: Liuqing surname: Yang fullname: Yang, Liuqing email: lyang7@mdanderson.org organization: Department of Medicine, Howard Hughes Medical Institute, University of California San Diego, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center – sequence: 2 givenname: Chunru surname: Lin fullname: Lin, Chunru email: clin2@mdanderson.org organization: Department of Medicine, Howard Hughes Medical Institute, University of California San Diego, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center – sequence: 3 givenname: Chunyu surname: Jin fullname: Jin, Chunyu organization: Department of Medicine, Howard Hughes Medical Institute, University of California San Diego – sequence: 4 givenname: Joy C. surname: Yang fullname: Yang, Joy C. organization: Department of Urology, School of Medicine, University of California Davis – sequence: 5 givenname: Bogdan surname: Tanasa fullname: Tanasa, Bogdan organization: Department of Medicine, Howard Hughes Medical Institute, University of California San Diego, Graduate Program, Kellogg School of Science and Technology, The Scripps Research Institute – sequence: 6 givenname: Wenbo surname: Li fullname: Li, Wenbo organization: Department of Medicine, Howard Hughes Medical Institute, University of California San Diego – sequence: 7 givenname: Daria surname: Merkurjev fullname: Merkurjev, Daria organization: Department of Medicine, Howard Hughes Medical Institute, University of California San Diego, Department of Bioengineering, Bioinformatics and System Biology Program, University of California San Diego – sequence: 8 givenname: Kenneth A. surname: Ohgi fullname: Ohgi, Kenneth A. organization: Department of Medicine, Howard Hughes Medical Institute, University of California San Diego – sequence: 9 givenname: Da surname: Meng fullname: Meng, Da organization: Department of Biological Sciences, Neurosciences Graduate Program, University of California San Diego – sequence: 10 givenname: Jie surname: Zhang fullname: Zhang, Jie organization: Department of Medicine, Howard Hughes Medical Institute, University of California San Diego – sequence: 11 givenname: Christopher P. surname: Evans fullname: Evans, Christopher P. organization: Department of Urology, School of Medicine, University of California Davis – sequence: 12 givenname: Michael G. surname: Rosenfeld fullname: Rosenfeld, Michael G. email: mrosenfeld@ucsd.edu organization: Department of Medicine, Howard Hughes Medical Institute, University of California San Diego |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23945587$$D View this record in MEDLINE/PubMed |
BookMark | eNqNk0tv1DAQgCNURLeFE3cU0QsIUhzHr1yQVhWPShVILZytWWeSpkrs1E4q-Pd4taVk0UJrHxzZn7-M7ZmDZM86i0nyPCfHOSnUOwvj5DGnjOePkkXOpMiYUHIvWRBCVUZUIfaTgxCuCCE8l-xJsk-LknGu5CK56Kw5_7LMKhzQVmjHtEdzCbYNfUhdnYKtvGvQZh4NDqPz8aOZOhixSuM0pmDG9gbG1tl0iKSHPjxNHtfQBXx2Ox4m3z9--HbyOTv7-un0ZHmWGSXlmEkjGF9xyUEBRahWqsqNKUFUFBQBFFgLkCtSy9gABFGUUsmxLirJKbDiMHm_8Q7TqsfKxOg9dHrwbQ_-p3bQ6u0V217qxt1oRgpWKBEFr24F3l1PGEbdt8Fg14FFNwWdC0FYRKW8H2W0pDkTfG09-gu9cpO38SYiFXVS0YL8oRroULe2djFEs5bqpeBlWapCsf9SBcsZV0zSSGU7qPXzxFPHZKnbOL1lfQg_97_cwZuhvdZz6T-huel4BxR7hX1rdob6oA3zP7ze2hCZEX-MDUwh6NOL8235fezc-2bDGu9C8Fjf5VlO9LoO9awOI_1inpp37O_Ci8DbDRDikm3Qz5Jkh-8X_Lc5PA |
CODEN | NATUAS |
CitedBy_id | crossref_primary_10_1038_s41392_019_0095_0 crossref_primary_10_1038_s41585_019_0195_1 crossref_primary_10_1101_gr_230243_117 crossref_primary_10_3389_fendo_2023_1156494 crossref_primary_10_3390_cancers12061458 crossref_primary_10_1158_0008_5472_CAN_19_3326 crossref_primary_10_1016_j_critrevonc_2024_104275 crossref_primary_10_3892_mco_2017_1462 crossref_primary_10_1093_nar_gkx156 crossref_primary_10_3389_fgene_2018_00744 crossref_primary_10_1016_j_mgene_2019_100595 crossref_primary_10_18632_aging_202553 crossref_primary_10_1186_s12943_018_0852_7 crossref_primary_10_3892_ol_2017_6319 crossref_primary_10_1016_j_bbadis_2017_12_029 crossref_primary_10_1371_journal_pone_0109443 crossref_primary_10_1007_s11255_017_1536_8 crossref_primary_10_1016_j_dld_2022_04_009 crossref_primary_10_1016_j_euf_2016_11_013 crossref_primary_10_1007_s11427_019_1613_3 crossref_primary_10_3390_cancers12082148 crossref_primary_10_3390_cells11213492 crossref_primary_10_18632_oncotarget_23254 crossref_primary_10_1158_1541_7786_MCR_15_0016_T crossref_primary_10_1080_15384101_2020_1748949 crossref_primary_10_1371_journal_pgen_1005640 crossref_primary_10_1002_cam4_3080 crossref_primary_10_1016_j_molmet_2015_12_003 crossref_primary_10_1186_s13046_016_0354_7 crossref_primary_10_1007_s12041_021_01269_3 crossref_primary_10_18632_oncotarget_11391 crossref_primary_10_3389_fgene_2021_671729 crossref_primary_10_1016_j_aohep_2020_100297 crossref_primary_10_1038_ncomms15622 crossref_primary_10_18632_oncotarget_1769 crossref_primary_10_3892_ijo_2023_5595 crossref_primary_10_3389_fonc_2021_753920 crossref_primary_10_3390_ijms18010040 crossref_primary_10_1016_j_cca_2015_02_046 crossref_primary_10_1016_j_pharmthera_2019_107447 crossref_primary_10_1016_j_gendis_2020_11_014 crossref_primary_10_1016_j_ymthe_2017_04_016 crossref_primary_10_1016_j_canlet_2022_215619 crossref_primary_10_1093_bioinformatics_bty981 crossref_primary_10_1172_JCI84421 crossref_primary_10_1016_j_ccell_2016_03_004 crossref_primary_10_1089_hum_2018_146 crossref_primary_10_1016_j_ccell_2016_03_010 crossref_primary_10_1093_jnci_djv431 crossref_primary_10_1080_10408363_2019_1657061 crossref_primary_10_3389_fmolb_2021_654718 crossref_primary_10_1155_2022_8058770 crossref_primary_10_1016_j_molmed_2014_03_005 crossref_primary_10_1016_j_ebiom_2020_103150 crossref_primary_10_1158_1055_9965_EPI_14_0377 crossref_primary_10_1016_j_ejso_2017_06_013 crossref_primary_10_1080_15384101_2021_1885236 crossref_primary_10_3389_fcell_2021_649605 crossref_primary_10_3389_fgene_2019_00018 crossref_primary_10_1038_s41388_020_1365_6 crossref_primary_10_1073_pnas_1501662112 crossref_primary_10_1016_j_eururo_2019_07_040 crossref_primary_10_1371_journal_pone_0100893 crossref_primary_10_1186_s12935_021_01926_8 crossref_primary_10_18632_oncotarget_2879 crossref_primary_10_3390_genes12122028 crossref_primary_10_1038_cr_2014_35 crossref_primary_10_1186_s41544_019_0033_x crossref_primary_10_1042_BSR20150278 crossref_primary_10_1063_1_4900657 crossref_primary_10_1016_j_compbiolchem_2022_107713 crossref_primary_10_18632_oncotarget_2770 crossref_primary_10_1016_j_cels_2019_09_005 crossref_primary_10_1038_nm_4368 crossref_primary_10_1055_s_0041_1729780 crossref_primary_10_1038_ncomms7520 crossref_primary_10_1111_jcmm_14502 crossref_primary_10_1016_j_prp_2020_153131 crossref_primary_10_18632_aging_101664 crossref_primary_10_4161_trns_28658 crossref_primary_10_1038_s41598_017_17996_6 crossref_primary_10_1210_endrev_bnab014 crossref_primary_10_18632_oncotarget_2406 crossref_primary_10_1016_j_canlet_2020_11_039 crossref_primary_10_1016_j_scib_2021_01_001 crossref_primary_10_1089_dna_2020_5453 crossref_primary_10_1016_j_eururo_2017_04_005 crossref_primary_10_1002_cam4_994 crossref_primary_10_1038_ncomms8743 crossref_primary_10_1155_2022_8051717 crossref_primary_10_3389_fgene_2022_864612 crossref_primary_10_1186_s12885_017_3339_9 crossref_primary_10_1038_ng_2805 crossref_primary_10_1038_s41416_023_02147_8 crossref_primary_10_1186_s12964_020_00691_x crossref_primary_10_1038_s41580_020_00315_9 crossref_primary_10_1177_1010428317697553 crossref_primary_10_1038_nsmb_3424 crossref_primary_10_1016_j_canlet_2016_03_003 crossref_primary_10_3390_biom11050664 crossref_primary_10_1080_15384101_2017_1317416 crossref_primary_10_18632_oncotarget_12163 crossref_primary_10_1586_14737140_2015_1007957 crossref_primary_10_1016_j_celrep_2015_07_033 crossref_primary_10_1016_j_ajur_2016_08_003 crossref_primary_10_1158_0008_5472_CAN_19_3460 crossref_primary_10_1007_s11427_013_4554_5 crossref_primary_10_3892_ol_2015_2846 crossref_primary_10_7717_peerj_7282 crossref_primary_10_1016_j_biocel_2018_08_017 crossref_primary_10_1007_s00439_021_02396_8 crossref_primary_10_1016_j_canlet_2019_08_010 crossref_primary_10_18632_oncotarget_17645 crossref_primary_10_18632_oncotarget_13167 crossref_primary_10_1158_0008_5472_CAN_20_3845 crossref_primary_10_1007_s13577_021_00583_3 crossref_primary_10_1172_JCI72124 crossref_primary_10_3390_cells10113198 crossref_primary_10_1007_s10555_016_9628_y crossref_primary_10_12677_IJPN_2016_53009 crossref_primary_10_3390_ijms22020632 crossref_primary_10_1016_j_biopha_2018_12_143 crossref_primary_10_1016_j_eururo_2013_12_003 crossref_primary_10_1016_j_trecan_2015_08_010 crossref_primary_10_3390_cimb45090459 crossref_primary_10_1016_j_celrep_2015_08_069 crossref_primary_10_1002_jcb_25427 crossref_primary_10_18632_oncotarget_16540 crossref_primary_10_1007_s00412_015_0570_5 crossref_primary_10_1016_j_ccell_2015_02_004 crossref_primary_10_4111_icu_20210305 crossref_primary_10_3390_ijms18061239 crossref_primary_10_1016_j_ncrna_2024_01_006 crossref_primary_10_1038_s41388_024_02945_1 crossref_primary_10_3390_ijms23010392 crossref_primary_10_1038_nbt_2943 crossref_primary_10_1038_s41419_020_2713_8 crossref_primary_10_3390_ijms160613322 crossref_primary_10_1016_j_biopha_2018_01_122 crossref_primary_10_1093_nar_gkad640 crossref_primary_10_1016_j_pharmthera_2018_04_001 crossref_primary_10_1038_aps_2014_18 crossref_primary_10_3389_fonc_2021_654472 crossref_primary_10_3390_ncrna6040049 crossref_primary_10_3390_life11111208 crossref_primary_10_1038_cgt_2017_14 crossref_primary_10_1080_02648725_2018_1471566 crossref_primary_10_18632_oncotarget_25038 crossref_primary_10_3390_ijms161226138 crossref_primary_10_1038_ncomms8821 crossref_primary_10_4161_cc_28104 crossref_primary_10_1038_s10038_020_0737_7 crossref_primary_10_1186_s12894_022_00969_x crossref_primary_10_1016_j_ygeno_2019_11_005 crossref_primary_10_1042_BSR20182498 crossref_primary_10_1002_cac2_12127 crossref_primary_10_1038_s41467_020_17325_y crossref_primary_10_3390_ijms150813993 crossref_primary_10_1155_2020_8847986 crossref_primary_10_1507_endocrj_EJ17_0328 crossref_primary_10_1080_15476286_2015_1053687 crossref_primary_10_1007_s00018_016_2174_5 crossref_primary_10_1016_j_tig_2014_06_001 crossref_primary_10_3390_ijms222111568 crossref_primary_10_1002_pros_24494 crossref_primary_10_1016_j_csbj_2020_11_004 crossref_primary_10_1016_j_nbd_2014_06_019 crossref_primary_10_1186_s40591_015_0042_6 crossref_primary_10_1002_iub_1474 crossref_primary_10_1159_000505154 crossref_primary_10_1007_s11033_019_04723_9 crossref_primary_10_1093_carcin_bgu019 crossref_primary_10_3389_fonc_2021_631551 crossref_primary_10_18632_oncotarget_7139 crossref_primary_10_1038_pcan_2015_48 crossref_primary_10_1038_pcan_2016_17 crossref_primary_10_3390_ijms17081208 crossref_primary_10_1016_j_bbrc_2016_01_056 crossref_primary_10_1111_age_12124 crossref_primary_10_1002_iub_2681 crossref_primary_10_1038_srep23343 crossref_primary_10_1146_annurev_genet_120213_092323 crossref_primary_10_1186_s13045_018_0663_8 crossref_primary_10_1002_pros_23453 crossref_primary_10_1186_s13059_017_1321_0 crossref_primary_10_1016_j_biocel_2014_03_012 crossref_primary_10_1038_s41598_019_42107_y crossref_primary_10_1371_journal_pone_0138236 crossref_primary_10_1038_leu_2014_169 crossref_primary_10_1111_jcmm_14102 crossref_primary_10_1186_s12943_017_0741_5 crossref_primary_10_1038_s41467_020_16966_3 crossref_primary_10_1016_j_tibs_2014_02_007 crossref_primary_10_1186_s13073_014_0077_3 crossref_primary_10_1038_s41586_023_06054_z crossref_primary_10_1111_cas_13352 crossref_primary_10_1080_21655979_2022_2031668 crossref_primary_10_1093_bfgp_elv049 crossref_primary_10_3389_fonc_2022_1024600 crossref_primary_10_1038_s41597_019_0179_2 crossref_primary_10_1038_srep34529 crossref_primary_10_3389_fgene_2020_567200 crossref_primary_10_1161_HYPERTENSIONAHA_120_14644 crossref_primary_10_3892_ol_2015_3186 crossref_primary_10_1002_mrd_22581 crossref_primary_10_1016_j_ccr_2014_07_009 crossref_primary_10_1038_scibx_2014_815 crossref_primary_10_1002_mc_23709 crossref_primary_10_3389_fgene_2021_802953 crossref_primary_10_3727_096504018X15220594629967 crossref_primary_10_1038_s41391_021_00378_5 crossref_primary_10_3892_mmr_2015_3474 crossref_primary_10_1016_j_cbi_2021_109396 crossref_primary_10_1016_j_cell_2014_10_013 crossref_primary_10_1016_j_bbagrm_2015_06_013 crossref_primary_10_3389_fendo_2017_00299 crossref_primary_10_1016_j_bbagrm_2015_06_015 crossref_primary_10_18632_oncotarget_1846 crossref_primary_10_3389_fgene_2018_00132 crossref_primary_10_1002_pros_24686 crossref_primary_10_7314_APJCP_2015_16_18_8067 crossref_primary_10_1002_cbin_11235 crossref_primary_10_1111_jcmm_13238 crossref_primary_10_1159_000502803 crossref_primary_10_1016_j_celrep_2020_02_107 crossref_primary_10_1093_bfgp_elv062 crossref_primary_10_1016_j_neo_2020_02_002 crossref_primary_10_1093_ibd_izaa009 crossref_primary_10_3389_fonc_2019_00739 crossref_primary_10_3389_fgene_2014_00057 crossref_primary_10_1530_JME_14_0134 crossref_primary_10_1016_j_cell_2014_05_049 crossref_primary_10_1038_nrm_2017_12 crossref_primary_10_3390_cancers14122902 crossref_primary_10_2217_pme_2016_0090 crossref_primary_10_1007_s11626_019_00414_8 crossref_primary_10_1080_15476286_2015_1060394 crossref_primary_10_1186_s12867_017_0091_2 crossref_primary_10_18632_oncotarget_9350 crossref_primary_10_1093_bfgp_elv057 crossref_primary_10_18632_aging_204888 crossref_primary_10_1016_j_canlet_2015_03_002 crossref_primary_10_1093_nar_gkac582 crossref_primary_10_1080_15592294_2020_1827723 crossref_primary_10_1016_j_yexmp_2020_104561 crossref_primary_10_1007_s10330_018_0291_1 crossref_primary_10_1109_TCBB_2020_3034910 crossref_primary_10_1016_j_molcel_2014_06_011 crossref_primary_10_1126_sciadv_aav5590 crossref_primary_10_18632_oncotarget_11962 crossref_primary_10_1016_j_beem_2015_07_003 crossref_primary_10_1007_s11010_024_04933_1 crossref_primary_10_1016_j_archoralbio_2020_104763 crossref_primary_10_1002_jcp_26311 crossref_primary_10_1016_j_ajur_2019_11_001 crossref_primary_10_1089_dna_2020_6194 crossref_primary_10_4161_23723548_2014_963469 crossref_primary_10_7717_peerj_6577 crossref_primary_10_1038_nm_3981 crossref_primary_10_1186_s13148_017_0380_0 crossref_primary_10_1111_cbdd_13567 crossref_primary_10_1007_s00438_016_1179_y crossref_primary_10_18632_aging_103355 crossref_primary_10_1155_2014_765207 crossref_primary_10_1093_nar_gkx600 crossref_primary_10_1177_1550762918801071 crossref_primary_10_1038_sdata_2018_31 crossref_primary_10_15252_embj_201591458 crossref_primary_10_1158_0008_5472_CAN_16_1508 crossref_primary_10_1038_srep19705 crossref_primary_10_1073_pnas_1415669112 crossref_primary_10_1007_s11427_020_1700_9 crossref_primary_10_1186_s12943_019_1039_6 crossref_primary_10_1002_pros_24186 crossref_primary_10_18632_oncotarget_21507 crossref_primary_10_1007_s11033_022_07427_9 crossref_primary_10_3390_cancers9010009 crossref_primary_10_1038_s42004_024_01227_x crossref_primary_10_18632_oncotarget_7509 crossref_primary_10_1016_j_gde_2015_07_001 crossref_primary_10_1186_1480_9222_16_11 crossref_primary_10_1038_nature14906 crossref_primary_10_1186_s12935_021_01843_w crossref_primary_10_1016_j_ncrna_2018_01_001 crossref_primary_10_1186_s12943_017_0680_1 crossref_primary_10_1158_0008_5472_CAN_16_2634 crossref_primary_10_1016_j_gde_2013_11_017 crossref_primary_10_52396_JUSTC_2022_0185 crossref_primary_10_1007_s00441_014_1885_x crossref_primary_10_1038_nrurol_2015_184 crossref_primary_10_1093_biosci_biu149 crossref_primary_10_1186_s13045_020_00852_y crossref_primary_10_1007_s13577_019_00296_8 crossref_primary_10_1080_21505594_2020_1857572 crossref_primary_10_1111_asj_12777 crossref_primary_10_1080_15476286_2016_1172756 crossref_primary_10_1136_jclinpath_2017_204718 crossref_primary_10_3390_cells13020191 crossref_primary_10_15412_J_JBTW_01061202 crossref_primary_10_1038_cddis_2017_181 crossref_primary_10_15252_embj_201798219 crossref_primary_10_1038_onc_2016_282 crossref_primary_10_1186_s12943_015_0314_4 crossref_primary_10_3389_fphys_2014_00155 crossref_primary_10_1186_s13148_017_0424_5 crossref_primary_10_1038_s41598_021_04664_z crossref_primary_10_1101_cshperspect_a026492 crossref_primary_10_3109_10408363_2014_906130 crossref_primary_10_7554_eLife_01749 crossref_primary_10_1016_j_tcb_2014_08_009 crossref_primary_10_1016_j_cell_2014_03_008 crossref_primary_10_1038_onc_2014_456 crossref_primary_10_1002_em_22472 crossref_primary_10_15430_JCP_2021_26_2_98 crossref_primary_10_1093_nsr_nwu008 crossref_primary_10_18632_oncotarget_21688 crossref_primary_10_1002_fsn3_1970 crossref_primary_10_1080_14728222_2018_1439016 crossref_primary_10_1016_j_canrad_2015_02_008 crossref_primary_10_1002_jcb_29113 crossref_primary_10_1016_j_tibs_2013_10_002 crossref_primary_10_3389_fgene_2020_00785 crossref_primary_10_3389_fgene_2015_00320 crossref_primary_10_1016_j_bbcan_2020_188491 crossref_primary_10_1016_j_mce_2018_10_023 crossref_primary_10_1002_ijc_32277 crossref_primary_10_1186_s12859_019_2675_y crossref_primary_10_1080_15384047_2019_1647058 crossref_primary_10_1186_s13058_015_0542_y crossref_primary_10_1038_nature12548 crossref_primary_10_1126_sciimmunol_ade4656 crossref_primary_10_3390_cancers14194877 crossref_primary_10_1038_s41419_018_1148_y crossref_primary_10_1016_j_canlet_2018_01_012 crossref_primary_10_1002_jcb_29364 crossref_primary_10_1042_BSR20180365 crossref_primary_10_1155_2022_4402536 crossref_primary_10_3390_cells12070987 crossref_primary_10_1016_j_mrrev_2017_11_001 crossref_primary_10_1186_s12943_019_1037_8 crossref_primary_10_1093_rheumatology_keaa395 crossref_primary_10_1016_j_lfs_2024_122544 crossref_primary_10_18632_oncotarget_7203 crossref_primary_10_1111_cas_13765 crossref_primary_10_1158_1541_7786_MCR_18_0087 crossref_primary_10_18632_oncotarget_10213 crossref_primary_10_1016_j_urolonc_2021_11_012 crossref_primary_10_1111_jcmm_14042 crossref_primary_10_1155_2019_8597953 crossref_primary_10_1016_j_celrep_2016_04_018 crossref_primary_10_1002_mc_23676 crossref_primary_10_1016_j_rbmo_2018_08_005 crossref_primary_10_1080_26895293_2020_1790431 crossref_primary_10_1007_s13277_016_5012_3 crossref_primary_10_18632_oncotarget_9519 crossref_primary_10_1093_nar_gkz804 crossref_primary_10_1002_cam4_2776 crossref_primary_10_1177_1933719114565037 crossref_primary_10_1186_1471_2407_14_932 crossref_primary_10_1093_database_bay039 crossref_primary_10_2139_ssrn_4120409 crossref_primary_10_18632_oncotarget_14920 crossref_primary_10_1038_s41467_017_02113_y crossref_primary_10_14791_btrt_2014_2_1_1 crossref_primary_10_3390_ijms21114068 crossref_primary_10_1016_j_currproblcancer_2014_11_004 crossref_primary_10_1007_s11427_013_4553_6 crossref_primary_10_1007_s40471_014_0017_1 crossref_primary_10_1073_pnas_1324151111 crossref_primary_10_1093_jmcb_mju013 crossref_primary_10_1007_s00018_017_2467_3 crossref_primary_10_1038_ncb3295 crossref_primary_10_1007_s13402_014_0180_x crossref_primary_10_1002_jcp_29667 crossref_primary_10_1186_s13073_021_00937_4 crossref_primary_10_1093_biolre_ioy230 crossref_primary_10_3892_or_2015_4364 crossref_primary_10_3390_ijms24054601 crossref_primary_10_1186_s12935_020_01543_x crossref_primary_10_3389_fonc_2023_1123101 crossref_primary_10_1016_j_celrep_2019_12_011 crossref_primary_10_1155_2020_4540312 crossref_primary_10_1093_nar_gkw113 crossref_primary_10_14336_AD_2019_0814 crossref_primary_10_1073_pnas_1424028112 crossref_primary_10_1093_nar_gkv262 crossref_primary_10_1002_wrna_1699 crossref_primary_10_1093_gigascience_giy050 crossref_primary_10_1002_1873_3468_14586 crossref_primary_10_1074_jbc_M116_718536 crossref_primary_10_1002_pros_22960 crossref_primary_10_1155_2020_1704631 crossref_primary_10_1158_0008_5472_CAN_18_0988 crossref_primary_10_1038_nrendo_2014_229 crossref_primary_10_1080_15476286_2023_2286099 crossref_primary_10_18632_oncotarget_5860 crossref_primary_10_1007_s40610_015_0002_6 crossref_primary_10_3389_fcell_2021_660853 crossref_primary_10_7124_bc_0008EB crossref_primary_10_1210_en_2017_03190 crossref_primary_10_3390_genes5020366 crossref_primary_10_1007_s00441_014_1842_8 crossref_primary_10_1016_j_canlet_2021_08_028 crossref_primary_10_1016_j_adcanc_2022_100067 crossref_primary_10_7554_eLife_28482 crossref_primary_10_1042_CS20181061 crossref_primary_10_7314_APJCP_2014_15_5_1909 crossref_primary_10_1093_biolre_ioz100 crossref_primary_10_1186_s12859_021_04207_3 crossref_primary_10_3892_mmr_2017_7051 crossref_primary_10_1126_science_aba4991 crossref_primary_10_1016_j_biopha_2020_110323 crossref_primary_10_1016_j_jbior_2015_10_001 crossref_primary_10_18632_oncotarget_14843 crossref_primary_10_1038_srep30709 crossref_primary_10_1016_j_cbpa_2021_111045 crossref_primary_10_1177_1010428317692259 crossref_primary_10_1210_en_2017_00619 crossref_primary_10_3727_096504017X15024935181289 crossref_primary_10_3892_ijmm_2022_5203 crossref_primary_10_1158_0008_5472_CAN_14_3607 crossref_primary_10_1038_srep42819 crossref_primary_10_1038_s41467_020_14323_y crossref_primary_10_1210_er_2014_1034 crossref_primary_10_1111_febs_16695 crossref_primary_10_1080_15476286_2019_1710405 crossref_primary_10_1016_j_canlet_2017_03_022 crossref_primary_10_1016_j_micpath_2018_05_050 crossref_primary_10_1186_s11658_018_0111_3 crossref_primary_10_1038_s42003_020_01120_y crossref_primary_10_2147_OTT_S251231 crossref_primary_10_2147_OTT_S243601 crossref_primary_10_1186_s13045_017_0470_7 crossref_primary_10_1155_2015_465184 crossref_primary_10_1016_j_canlet_2019_11_007 crossref_primary_10_1371_journal_pone_0220931 crossref_primary_10_2174_1568009620666210106122421 crossref_primary_10_1016_j_ebiom_2016_02_028 crossref_primary_10_3389_fonc_2019_01260 crossref_primary_10_18632_oncotarget_21185 crossref_primary_10_3389_fmicb_2022_962186 crossref_primary_10_3389_fcell_2021_655018 crossref_primary_10_1155_2014_591703 crossref_primary_10_1158_1078_0432_CCR_14_3106 crossref_primary_10_3390_ijms24021305 crossref_primary_10_18632_oncotarget_10170 crossref_primary_10_18632_oncotarget_12476 crossref_primary_10_1016_j_mce_2021_111197 crossref_primary_10_1016_j_cell_2021_03_050 crossref_primary_10_3389_fgene_2022_1032958 crossref_primary_10_1002_jcp_28517 crossref_primary_10_1186_1471_2105_15_311 crossref_primary_10_3389_fimmu_2018_03184 crossref_primary_10_1007_s13277_014_2636_z crossref_primary_10_1016_j_bbagrm_2018_12_006 crossref_primary_10_1016_j_canlet_2016_01_033 crossref_primary_10_1016_j_canlet_2017_03_040 crossref_primary_10_1134_S0026893322020121 crossref_primary_10_3390_cancers16030523 crossref_primary_10_1016_j_cpt_2022_12_003 crossref_primary_10_1002_ijc_31818 crossref_primary_10_1038_s41598_017_02311_0 crossref_primary_10_1016_j_aqrep_2022_101367 crossref_primary_10_1016_j_cyto_2016_06_017 crossref_primary_10_1007_s13277_016_5141_8 crossref_primary_10_1186_s13287_017_0485_6 crossref_primary_10_1038_nsmb_3249 crossref_primary_10_1016_j_ymeth_2017_01_010 crossref_primary_10_3389_fonc_2022_847745 crossref_primary_10_1158_0008_5472_CAN_17_3564 |
Cites_doi | 10.1038/nature08975 10.1038/nature12209 10.1083/jcb.200810133 10.1158/0008-5472.CAN-08-2764 10.1093/bioinformatics/btp616 10.1210/er.2002-0032 10.1016/j.molcel.2011.08.027 10.1111/j.1349-7006.2010.01737.x 10.1093/bioinformatics/btp340 10.4161/cc.11.1.18402 10.1038/nature12210 10.1038/sj.onc.1207069 10.1038/nature07829 10.1016/j.cell.2009.07.031 10.1016/S0076-6879(06)11009-5 10.1093/bioinformatics/btq033 10.1038/nature09272 10.1002/ijc.24778 10.1016/j.molcel.2005.07.018 10.1186/gb-2009-10-3-r25 10.1016/j.molcel.2010.12.011 10.1038/nature10006 10.1016/j.molcel.2010.05.004 10.1016/j.cell.2011.08.054 10.1200/JCO.2005.03.4777 10.1038/nrurol.2012.116 10.1074/jbc.272.10.6146 10.1128/MCB.23.23.8563-8575.2003 10.1016/j.cell.2011.10.040 10.1126/science.1192002 |
ContentType | Journal Article |
Copyright | Springer Nature Limited 2013 COPYRIGHT 2013 Nature Publishing Group Copyright Nature Publishing Group Aug 29, 2013 |
Copyright_xml | – notice: Springer Nature Limited 2013 – notice: COPYRIGHT 2013 Nature Publishing Group – notice: Copyright Nature Publishing Group Aug 29, 2013 |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7QG 7QL 7QP 7QR 7RV 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7X2 7X7 7XB 88A 88E 88G 88I 8AF 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK 8G5 ABJCF ABUWG AFKRA ARAPS ATCPS AZQEC BBNVY BEC BENPR BGLVJ BHPHI BKSAR C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M2M M2O M2P M7N M7P M7S MBDVC NAPCQ P5Z P62 P64 PATMY PCBAR PDBOC PQEST PQQKQ PQUKI PSYQQ PTHSS PYCSY Q9U R05 RC3 S0X SOI 7X8 5PM |
DOI | 10.1038/nature12451 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Meteorological & Geoastrophysical Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) STEM Database ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest Central UK/Ireland Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection eLibrary ProQuest Central Technology Collection Natural Science Collection Earth, Atmospheric & Aquatic Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agriculture Science Database Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Psychology Database Research Library Science Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Research Library (Corporate) Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Earth, Atmospheric & Aquatic Science Database Materials Science Collection ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest One Psychology Engineering Collection Environmental Science Collection ProQuest Central Basic University of Michigan Genetics Abstracts SIRS Editorial Environment Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Agricultural Science Database ProQuest One Psychology Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts elibrary ProQuest AP Science SciTech Premium Collection Environmental Sciences and Pollution Management Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Biological Science Collection Chemoreception Abstracts ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Earth, Atmospheric & Aquatic Science Database Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts Meteorological & Geoastrophysical Abstracts - Academic University of Michigan Technology Collection Technology Research Database SIRS Editorial Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Earth, Atmospheric & Aquatic Science Collection Genetics Abstracts ProQuest Engineering Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Research Library ProQuest Materials Science Collection ProQuest Public Health ProQuest Central Basic ProQuest Science Journals ProQuest Nursing & Allied Health Source ProQuest Psychology Journals (Alumni) ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library ProQuest Psychology Journals Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | MEDLINE Agricultural Science Database Genetics Abstracts |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Sciences (General) Physics |
EISSN | 1476-4687 |
EndPage | 602 |
ExternalDocumentID | 3104304051 A659998384 A341458472 10_1038_nature12451 23945587 |
Genre | Research Support, U.S. Gov't, Non-P.H.S Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
GeographicLocations | United States |
GeographicLocations_xml | – name: United States |
GrantInformation_xml | – fundername: NCI NIH HHS grantid: R00 CA166527 – fundername: NCI NIH HHS grantid: CA173903 – fundername: NCI NIH HHS grantid: R01 CA173903 – fundername: NIDDK NIH HHS grantid: DK18477 – fundername: Howard Hughes Medical Institute – fundername: NIDDK NIH HHS grantid: T32 DK007541 – fundername: NIDDK NIH HHS grantid: R01 DK018477 – fundername: NIDDK NIH HHS grantid: 1K99DK094981-01 – fundername: NIDDK NIH HHS grantid: DK039949 – fundername: NIDDK NIH HHS grantid: R01 DK039949 |
GroupedDBID | --- --Z -DZ -ET -~X .55 .CO .XZ 00M 07C 0R~ 0WA 123 186 1OL 1VR 29M 2KS 2XV 39C 3V. 4.4 41X 53G 5RE 6TJ 70F 7RV 7X2 7X7 7XC 85S 88A 88E 88I 8AF 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ 8G5 8R4 8R5 8WZ 97F 97L A6W A7Z A8Z AAEEF AAHBH AAHTB AAIKC AAKAB AAKAS AAMNW AASDW AAYEP AAZLF ABAWZ ABDBF ABFSI ABIVO ABJCF ABJNI ABLJU ABOCM ABPEJ ABPPZ ABUWG ABVXF ABWJO ABZEH ACBEA ACBWK ACGFO ACGFS ACGOD ACIWK ACKOT ACMJI ACNCT ACPRK ACWUS ADBBV ADFRT ADUKH ADYSU ADZCM AENEX AFFNX AFKRA AFLOW AFRAH AFRQD AFSHS AGAYW AGEZK AGHSJ AGHTU AGNAY AGSOS AHMBA AHSBF AIDAL AIDUJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH APEBS ARAPS ARMCB ARTTT ASPBG ATCPS ATWCN AVWKF AXYYD AZFZN AZQEC B-7 B0M BBNVY BCU BDKGC BEC BENPR BGLVJ BHPHI BIN BKEYQ BKKNO BKSAR BLC BPHCQ BVXVI CCPQU CJ0 CS3 D1I D1J D1K DO4 DU5 DWQXO E.- E.L EAD EAP EAS EAZ EBC EBD EBO EBS ECC EE. EJD EMB EMF EMH EMK EMOBN EPL EPS ESE ESN ESTFP ESX EX3 EXGXG F20 F5P FEDTE FQGFK FSGXE FYUFA GNUQQ GUQSH HCIFZ HMCUK HVGLF HZ~ I-F IAO ICQ IEA IEP IGS IH2 IHR INH INR IOF IPY ISR ITC K6- KB. KOO L6V L7B LK5 LK8 LSO M0K M0L M1P M2M M2O M2P M7P M7R M7S N9A NAPCQ NEJ NEPJS O9- OBC OES OHH OMK OVD P-O P2P P62 PATMY PCBAR PDBOC PM3 PQQKQ PROAC PSQYO PSYQQ PTHSS PYCSY Q2X R05 RND RNS RNT RNTTT RXW S0X SC5 SHXYY SIXXV SJFOW SJN SNYQT SV3 TAE TAOOD TBHMF TDRGL TEORI TH9 TN5 TSG TUS TWZ U5U UIG UKHRP UKR UMD UQL VQA VVN WH7 WOW X7M XIH XKW XZL Y6R YAE YCJ YFH YNT YOC YQT YR2 YXB YZZ ZCA ZE2 ZKB ~02 ~7V ~88 ~8M ~KM AAYZH CGR CUY CVF ECM EIF NPM AAYXX CITATION AADEA AAEXX ABEEJ ADFPY ADZGE AETEA NXXTH AADWK AAGJQ AAJMP AAYJO ABGIJ ACBMV ACBRV ACBYP ACIGE ACTTH ACVWB ADMDM ADQMX AEDAW AEFTE AFNRJ AGGBP AGPPL AHGBK AHPSJ AJDOV AMRJV I-U U1R XFK ZA5 08R AAPBV ABGFU ABPTK AEQTP 7QG 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7XB 8FD 8FK C1K FR3 H94 K9. KL. M7N MBDVC P64 PQEST PQUKI Q9U RC3 SOI 7X8 5PM |
ID | FETCH-LOGICAL-c877t-7c645b575a8a2eadb8d1cc9a6d2a80ae6ef6a7b0f7777aa60822275ef3d752a43 |
IEDL.DBID | 8C1 |
ISSN | 0028-0836 |
IngestDate | Tue Sep 17 21:24:07 EDT 2024 Fri Aug 16 08:48:31 EDT 2024 Sat Oct 05 06:29:02 EDT 2024 Thu Oct 10 21:03:49 EDT 2024 Thu Feb 22 23:33:57 EST 2024 Thu Feb 22 23:40:14 EST 2024 Fri Feb 02 04:48:20 EST 2024 Fri Feb 02 05:03:06 EST 2024 Tue Dec 12 21:20:08 EST 2023 Tue Dec 12 21:18:46 EST 2023 Fri Feb 02 04:34:44 EST 2024 Fri Feb 02 04:17:09 EST 2024 Thu Aug 01 20:13:33 EDT 2024 Thu Aug 01 20:13:24 EDT 2024 Thu Sep 26 19:05:30 EDT 2024 Tue Oct 15 23:48:56 EDT 2024 Fri Oct 11 20:46:18 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 7464 |
Language | English |
License | Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c877t-7c645b575a8a2eadb8d1cc9a6d2a80ae6ef6a7b0f7777aa60822275ef3d752a43 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC4034386 |
PMID | 23945587 |
PQID | 1443478230 |
PQPubID | 40569 |
PageCount | 5 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4034386 proquest_miscellaneous_1660434377 proquest_miscellaneous_1429214656 proquest_journals_1443478230 gale_infotracmisc_A659998384 gale_infotracmisc_A341458472 gale_infotracgeneralonefile_A659998384 gale_infotracgeneralonefile_A341458472 gale_infotraccpiq_659998384 gale_infotraccpiq_341458472 gale_infotracacademiconefile_A659998384 gale_infotracacademiconefile_A341458472 gale_incontextgauss_ISR_A659998384 gale_incontextgauss_ISR_A341458472 crossref_primary_10_1038_nature12451 pubmed_primary_23945587 springer_journals_10_1038_nature12451 |
PublicationCentury | 2000 |
PublicationDate | 2013-08-29 |
PublicationDateYYYYMMDD | 2013-08-29 |
PublicationDate_xml | – month: 08 year: 2013 text: 2013-08-29 day: 29 |
PublicationDecade | 2010 |
PublicationPlace | London |
PublicationPlace_xml | – name: London – name: England |
PublicationSubtitle | International weekly journal of science |
PublicationTitle | Nature (London) |
PublicationTitleAbbrev | Nature |
PublicationTitleAlternate | Nature |
PublicationYear | 2013 |
Publisher | Nature Publishing Group UK Nature Publishing Group |
Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
References | Wang (CR17) 2011; 474 Lam (CR19) 2013; 498 Fu (CR8) 2003; 23 Kypta, Waxman (CR7) 2012; 9 heintzman (CR11) 2009; 459 Quinlan, Hall (CR24) 2010; 26 Heinz (CR23) 2010; 38 Hu (CR12) 2009; 69 Scher, Sawyers (CR3) 2005; 23 Gupta (CR1) 2010; 464 Wang, Carroll, Brown (CR15) 2005; 19 Gu (CR16) 2009; 185 Saeed (CR25) 2006; 411 Sun (CR13) 2010; 126 Li (CR20) 2013; 498 Zippo (CR10) 2009; 138 Robinson, McCarthy, Smyth (CR27) 2010; 26 Chu, Qu, Zhong, Artandi, Chang (CR6) 2011; 44 Liao, Monia, Dean, Berk (CR30) 1997; 272 Petrovics (CR4) 2004; 23 Tsai (CR29) 2010; 329 Langmead, Trapnell, Pop, Salzberg (CR22) 2009; 10 Yang (CR9) 2011; 147 Zang (CR26) 2009; 25 Gu, Watanabe, Dai (CR18) 2012; 11 Zhao (CR21) 2010; 40 Heinlein, Chang (CR2) 2004; 25 Chung (CR5) 2011; 102 Taberlay (CR14) 2011; 147 Liu (CR28) 2010; 466 16939790 - Methods Enzymol. 2006;411:134-93 20622854 - Nature. 2010 Jul 22;466(7305):508-12 19766566 - Cell. 2009 Sep 18;138(6):1122-36 21963238 - Mol Cell. 2011 Nov 18;44(4):667-78 14612401 - Mol Cell Biol. 2003 Dec;23(23):8563-75 22153073 - Cell. 2011 Dec 9;147(6):1283-94 19487454 - J Cell Biol. 2009 Jun 1;185(5):811-26 14724589 - Oncogene. 2004 Jan 15;23(2):605-11 24435053 - Asian J Androl. 2014 Mar-Apr;16(2):268-9 19117982 - Cancer Res. 2009 Jan 1;69(1):16-22 15082523 - Endocr Rev. 2004 Apr;25(2):276-308 24745541 - J Urol. 2014 May;191(5):1470-1 22186018 - Cell Cycle. 2012 Jan 1;11(1):79-87 20874843 - Cancer Sci. 2011 Jan;102(1):245-52 22078878 - Cell. 2011 Nov 11;147(4):773-88 23728302 - Nature. 2013 Jun 27;498(7455):516-20 21572438 - Nature. 2011 Jun 16;474(7351):390-4 16137620 - Mol Cell. 2005 Sep 2;19(5):631-42 9045626 - J Biol Chem. 1997 Mar 7;272(10):6146-50 19910308 - Bioinformatics. 2010 Jan 1;26(1):139-40 20513432 - Mol Cell. 2010 May 28;38(4):576-89 22710668 - Nat Rev Urol. 2012 Aug;9(8):418-28 19261174 - Genome Biol. 2009;10(3):R25 23945584 - Nature. 2013 Aug 29;500(7464):536-7 19505939 - Bioinformatics. 2009 Aug 1;25(15):1952-8 16278481 - J Clin Oncol. 2005 Nov 10;23(32):8253-61 20393566 - Nature. 2010 Apr 15;464(7291):1071-6 19295514 - Nature. 2009 May 7;459(7243):108-12 20110278 - Bioinformatics. 2010 Mar 15;26(6):841-2 21172659 - Mol Cell. 2010 Dec 22;40(6):939-53 20616235 - Science. 2010 Aug 6;329(5992):689-93 23728303 - Nature. 2013 Jun 27;498(7455):511-5 24713835 - Asian J Androl. 2014 May-Jun;16(3):418-9 19642108 - Int J Cancer. 2010 Feb 1;126(3):764-74 RA Gupta (BFnature12451_CR1) 2010; 464 C Zang (BFnature12451_CR26) 2009; 25 B Gu (BFnature12451_CR16) 2009; 185 Q Wang (BFnature12451_CR15) 2005; 19 L Yang (BFnature12451_CR9) 2011; 147 A Zippo (BFnature12451_CR10) 2009; 138 G Petrovics (BFnature12451_CR4) 2004; 23 RM Kypta (BFnature12451_CR7) 2012; 9 A Sun (BFnature12451_CR13) 2010; 126 MTY Lam (BFnature12451_CR19) 2013; 498 S Heinz (BFnature12451_CR23) 2010; 38 ND heintzman (BFnature12451_CR11) 2009; 459 PC Taberlay (BFnature12451_CR14) 2011; 147 M Fu (BFnature12451_CR8) 2003; 23 MC Tsai (BFnature12451_CR29) 2010; 329 W Liu (BFnature12451_CR28) 2010; 466 B Langmead (BFnature12451_CR22) 2009; 10 CA Heinlein (BFnature12451_CR2) 2004; 25 AR Quinlan (BFnature12451_CR24) 2010; 26 B Gu (BFnature12451_CR18) 2012; 11 S Chung (BFnature12451_CR5) 2011; 102 W Li (BFnature12451_CR20) 2013; 498 AI Saeed (BFnature12451_CR25) 2006; 411 D Wang (BFnature12451_CR17) 2011; 474 R Hu (BFnature12451_CR12) 2009; 69 J Zhao (BFnature12451_CR21) 2010; 40 MD Robinson (BFnature12451_CR27) 2010; 26 DF Liao (BFnature12451_CR30) 1997; 272 C Chu (BFnature12451_CR6) 2011; 44 HI Scher (BFnature12451_CR3) 2005; 23 |
References_xml | – volume: 464 start-page: 1071 year: 2010 end-page: 1076 ident: CR1 article-title: Long non-coding RNA reprograms chromatin state to promote cancer metastasis publication-title: Nature doi: 10.1038/nature08975 contributor: fullname: Gupta – volume: 498 start-page: 511 year: 2013 end-page: 515 ident: CR19 article-title: Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription publication-title: Nature doi: 10.1038/nature12209 contributor: fullname: Lam – volume: 185 start-page: 811 year: 2009 end-page: 826 ident: CR16 article-title: Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation publication-title: J. Cell Biol. doi: 10.1083/jcb.200810133 contributor: fullname: Gu – volume: 69 start-page: 16 year: 2009 end-page: 22 ident: CR12 article-title: Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-08-2764 contributor: fullname: Hu – volume: 26 start-page: 139 year: 2010 end-page: 140 ident: CR27 article-title: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp616 contributor: fullname: Smyth – volume: 25 start-page: 276 year: 2004 end-page: 308 ident: CR2 article-title: Androgen receptor in prostate cancer publication-title: Endocr. Rev. doi: 10.1210/er.2002-0032 contributor: fullname: Chang – volume: 44 start-page: 667 year: 2011 end-page: 678 ident: CR6 article-title: Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions publication-title: Mol. Cell doi: 10.1016/j.molcel.2011.08.027 contributor: fullname: Chang – volume: 102 start-page: 245 year: 2011 end-page: 252 ident: CR5 article-title: Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility publication-title: Cancer Sci. doi: 10.1111/j.1349-7006.2010.01737.x contributor: fullname: Chung – volume: 25 start-page: 1952 year: 2009 end-page: 1958 ident: CR26 article-title: A clustering approach for identification of enriched domains from histone modification ChIP-Seq data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp340 contributor: fullname: Zang – volume: 11 start-page: 79 year: 2012 end-page: 87 ident: CR18 article-title: Pygo2 regulates histone gene expression and H3 K56 acetylation in human mammary epithelial cells publication-title: Cell Cycle doi: 10.4161/cc.11.1.18402 contributor: fullname: Dai – volume: 498 start-page: 516 year: 2013 end-page: 520 ident: CR20 article-title: Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation publication-title: Nature doi: 10.1038/nature12210 contributor: fullname: Li – volume: 23 start-page: 605 year: 2004 end-page: 611 ident: CR4 article-title: Elevated expression of , a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients publication-title: Oncogene doi: 10.1038/sj.onc.1207069 contributor: fullname: Petrovics – volume: 459 start-page: 108 year: 2009 end-page: 112 ident: CR11 article-title: Histone modifications at human enhancers reflect global cell-type-specific gene expression publication-title: Nature doi: 10.1038/nature07829 contributor: fullname: heintzman – volume: 138 start-page: 1122 year: 2009 end-page: 1136 ident: CR10 article-title: Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation publication-title: Cell doi: 10.1016/j.cell.2009.07.031 contributor: fullname: Zippo – volume: 411 start-page: 134 year: 2006 end-page: 193 ident: CR25 article-title: TM4 microarray software suite publication-title: Methods Enzymol. doi: 10.1016/S0076-6879(06)11009-5 contributor: fullname: Saeed – volume: 26 start-page: 841 year: 2010 end-page: 842 ident: CR24 article-title: BEDTools: a flexible suite of utilities for comparing genomic features publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq033 contributor: fullname: Hall – volume: 466 start-page: 508 year: 2010 end-page: 512 ident: CR28 article-title: PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression publication-title: Nature doi: 10.1038/nature09272 contributor: fullname: Liu – volume: 126 start-page: 764 year: 2010 end-page: 774 ident: CR13 article-title: Adeno-associated virus-delivered short hairpin-structured RNA for androgen receptor gene silencing induces tumor eradication of prostate cancer xenografts in nude mice: a preclinical study publication-title: Int. J. Cancer doi: 10.1002/ijc.24778 contributor: fullname: Sun – volume: 19 start-page: 631 year: 2005 end-page: 642 ident: CR15 article-title: Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking publication-title: Mol. Cell doi: 10.1016/j.molcel.2005.07.018 contributor: fullname: Brown – volume: 10 start-page: R25 year: 2009 ident: CR22 article-title: Ultrafast and memory-efficient alignment of short DNA sequences to the human genome publication-title: Genome Biol. doi: 10.1186/gb-2009-10-3-r25 contributor: fullname: Salzberg – volume: 40 start-page: 939 year: 2010 end-page: 953 ident: CR21 article-title: Genome-wide identification of polycomb-associated RNAs by RIP-seq publication-title: Mol. Cell doi: 10.1016/j.molcel.2010.12.011 contributor: fullname: Zhao – volume: 474 start-page: 390 year: 2011 end-page: 394 ident: CR17 article-title: Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA publication-title: Nature doi: 10.1038/nature10006 contributor: fullname: Wang – volume: 38 start-page: 576 year: 2010 end-page: 589 ident: CR23 article-title: Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities publication-title: Mol. Cell doi: 10.1016/j.molcel.2010.05.004 contributor: fullname: Heinz – volume: 147 start-page: 773 year: 2011 end-page: 788 ident: CR9 article-title: ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs publication-title: Cell doi: 10.1016/j.cell.2011.08.054 contributor: fullname: Yang – volume: 23 start-page: 8253 year: 2005 end-page: 8261 ident: CR3 article-title: Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2005.03.4777 contributor: fullname: Sawyers – volume: 9 start-page: 418 year: 2012 end-page: 428 ident: CR7 article-title: Wnt/β-catenin signalling in prostate cancer publication-title: Nature Rev. Urology doi: 10.1038/nrurol.2012.116 contributor: fullname: Waxman – volume: 272 start-page: 6146 year: 1997 end-page: 6150 ident: CR30 article-title: Protein kinase C-ζ mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.10.6146 contributor: fullname: Berk – volume: 23 start-page: 8563 year: 2003 end-page: 8575 ident: CR8 article-title: Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.23.23.8563-8575.2003 contributor: fullname: Fu – volume: 147 start-page: 1283 year: 2011 end-page: 1294 ident: CR14 article-title: Polycomb-repressed genes have permissive enhancers that initiate reprogramming publication-title: Cell doi: 10.1016/j.cell.2011.10.040 contributor: fullname: Taberlay – volume: 329 start-page: 689 year: 2010 end-page: 693 ident: CR29 article-title: Long noncoding RNA as modular scaffold of histone modification complexes publication-title: Science doi: 10.1126/science.1192002 contributor: fullname: Tsai – volume: 9 start-page: 418 year: 2012 ident: BFnature12451_CR7 publication-title: Nature Rev. Urology doi: 10.1038/nrurol.2012.116 contributor: fullname: RM Kypta – volume: 25 start-page: 276 year: 2004 ident: BFnature12451_CR2 publication-title: Endocr. Rev. doi: 10.1210/er.2002-0032 contributor: fullname: CA Heinlein – volume: 329 start-page: 689 year: 2010 ident: BFnature12451_CR29 publication-title: Science doi: 10.1126/science.1192002 contributor: fullname: MC Tsai – volume: 38 start-page: 576 year: 2010 ident: BFnature12451_CR23 publication-title: Mol. Cell doi: 10.1016/j.molcel.2010.05.004 contributor: fullname: S Heinz – volume: 498 start-page: 511 year: 2013 ident: BFnature12451_CR19 publication-title: Nature doi: 10.1038/nature12209 contributor: fullname: MTY Lam – volume: 25 start-page: 1952 year: 2009 ident: BFnature12451_CR26 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp340 contributor: fullname: C Zang – volume: 138 start-page: 1122 year: 2009 ident: BFnature12451_CR10 publication-title: Cell doi: 10.1016/j.cell.2009.07.031 contributor: fullname: A Zippo – volume: 26 start-page: 139 year: 2010 ident: BFnature12451_CR27 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp616 contributor: fullname: MD Robinson – volume: 411 start-page: 134 year: 2006 ident: BFnature12451_CR25 publication-title: Methods Enzymol. doi: 10.1016/S0076-6879(06)11009-5 contributor: fullname: AI Saeed – volume: 147 start-page: 1283 year: 2011 ident: BFnature12451_CR14 publication-title: Cell doi: 10.1016/j.cell.2011.10.040 contributor: fullname: PC Taberlay – volume: 19 start-page: 631 year: 2005 ident: BFnature12451_CR15 publication-title: Mol. Cell doi: 10.1016/j.molcel.2005.07.018 contributor: fullname: Q Wang – volume: 474 start-page: 390 year: 2011 ident: BFnature12451_CR17 publication-title: Nature doi: 10.1038/nature10006 contributor: fullname: D Wang – volume: 459 start-page: 108 year: 2009 ident: BFnature12451_CR11 publication-title: Nature doi: 10.1038/nature07829 contributor: fullname: ND heintzman – volume: 69 start-page: 16 year: 2009 ident: BFnature12451_CR12 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-08-2764 contributor: fullname: R Hu – volume: 23 start-page: 8563 year: 2003 ident: BFnature12451_CR8 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.23.23.8563-8575.2003 contributor: fullname: M Fu – volume: 126 start-page: 764 year: 2010 ident: BFnature12451_CR13 publication-title: Int. J. Cancer doi: 10.1002/ijc.24778 contributor: fullname: A Sun – volume: 11 start-page: 79 year: 2012 ident: BFnature12451_CR18 publication-title: Cell Cycle doi: 10.4161/cc.11.1.18402 contributor: fullname: B Gu – volume: 10 start-page: R25 year: 2009 ident: BFnature12451_CR22 publication-title: Genome Biol. doi: 10.1186/gb-2009-10-3-r25 contributor: fullname: B Langmead – volume: 40 start-page: 939 year: 2010 ident: BFnature12451_CR21 publication-title: Mol. Cell doi: 10.1016/j.molcel.2010.12.011 contributor: fullname: J Zhao – volume: 466 start-page: 508 year: 2010 ident: BFnature12451_CR28 publication-title: Nature doi: 10.1038/nature09272 contributor: fullname: W Liu – volume: 44 start-page: 667 year: 2011 ident: BFnature12451_CR6 publication-title: Mol. Cell doi: 10.1016/j.molcel.2011.08.027 contributor: fullname: C Chu – volume: 23 start-page: 8253 year: 2005 ident: BFnature12451_CR3 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2005.03.4777 contributor: fullname: HI Scher – volume: 26 start-page: 841 year: 2010 ident: BFnature12451_CR24 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq033 contributor: fullname: AR Quinlan – volume: 464 start-page: 1071 year: 2010 ident: BFnature12451_CR1 publication-title: Nature doi: 10.1038/nature08975 contributor: fullname: RA Gupta – volume: 185 start-page: 811 year: 2009 ident: BFnature12451_CR16 publication-title: J. Cell Biol. doi: 10.1083/jcb.200810133 contributor: fullname: B Gu – volume: 498 start-page: 516 year: 2013 ident: BFnature12451_CR20 publication-title: Nature doi: 10.1038/nature12210 contributor: fullname: W Li – volume: 102 start-page: 245 year: 2011 ident: BFnature12451_CR5 publication-title: Cancer Sci. doi: 10.1111/j.1349-7006.2010.01737.x contributor: fullname: S Chung – volume: 23 start-page: 605 year: 2004 ident: BFnature12451_CR4 publication-title: Oncogene doi: 10.1038/sj.onc.1207069 contributor: fullname: G Petrovics – volume: 147 start-page: 773 year: 2011 ident: BFnature12451_CR9 publication-title: Cell doi: 10.1016/j.cell.2011.08.054 contributor: fullname: L Yang – volume: 272 start-page: 6146 year: 1997 ident: BFnature12451_CR30 publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.10.6146 contributor: fullname: DF Liao |
SSID | ssj0005174 |
Score | 2.647383 |
Snippet | A study of prostate cancer cells reveals a transcriptional activation role for long non-coding RNAs (PRNCR1 and PCGEM1) that bind to the androgen receptor, and... Although recent studies have indicated roles of long non-coding RNAs (lncRNAs) in physiological aspects of cell-type determination and tissue homeostasis,... While recent studies indicated roles of long non-coding RNAs (lncRNAs) in physiologic aspects of cell-type determination and tissue homeostasis 1 yet their... |
SourceID | pubmedcentral proquest gale crossref pubmed springer |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 598 |
SubjectTerms | 631/337/384/2568 631/337/572 631/67 Androgens Animals Binding sites Castration Cell Line, Tumor Cell Proliferation Development and progression Efficiency Enhancer Elements, Genetic - genetics Experiments Gene expression Genetic aspects Genetic regulation Humanities and Social Sciences Humans letter Male Mass spectrometry Mice Mice, Nude multidisciplinary Neoplasm Transplantation Physiological aspects Promoter Regions, Genetic - genetics Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Proteins Receptors, Androgen - metabolism Recruitment RNA, Long Noncoding - genetics Science Transcription Factors - metabolism Transcriptional Activation - genetics Up-Regulation - genetics |
Title | lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs |
URI | https://link.springer.com/article/10.1038/nature12451 https://www.ncbi.nlm.nih.gov/pubmed/23945587 https://www.proquest.com/docview/1443478230 https://search.proquest.com/docview/1429214656 https://search.proquest.com/docview/1660434377 https://pubmed.ncbi.nlm.nih.gov/PMC4034386 |
Volume | 500 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhR1db9Mw0GKbkHhB2_hY2KgCGl8P0VI7_sgTKtPKQKJCZZP6FjmxMyqxpFva_7-7xC1JqUof-tA7X93c-e7q-yLklOY6t4rXnY8VhhlFEButApYanPQQGWqwwPnHSFxeR98nfOIu3CqXVrnUibWiNmWGd-Rn4PizSGJY6PPsLsCpURhddSM0dsheHwQTRzeo81aKx1oXZlefFzJ11rTNBOPG-x2LtK6XW4ZpPWlyLXJaG6ThPnnqPEl_0LD-gDyyxSF5XGd0ZtUhOXCntvI_utbSn56Rqz9FNh4NguXo27l_a7H0d1rdVn6Z-xrbF4BIBaAH7Qz-jgf-fTOs3hofPrc-1kE0t7i-S-2qnpPr4cXV-WXg5ioEmZJyHshMRDwFP00rTUGSUmX6WRZrYahWobbC5kLLNMwlvLQW9dBvyW3OjORUR-wF2S3Kwh4RPzeh7mtGLbhJkUn7seIWfEjGqGaxMsYjp8tnm8ya9hlJHfZmKmmxwCNv8bkn2JCiwIyXG72oquTbr3EyADNbx3LpNiTBwdEFaYs88sEh5SWwKdOuygC2i42uOuT-g9miedzBzGbTu6RFZwO0tfZ9B3rTcHzTdrYjtiiedBBBHWQdOpvA7dVL0U6ctqqSv2fLI29WYFyJGXiFLReIQ2McAs_FFhwhQqxUltIjL5vTsuI6ZXHEuQKI7JyjFQL2Oe9Ciunvut95FAJNBd_7bnniWlv_V5hebf-Jx-QJrUeaYPXRCdmd3y_sa3As52mP7MiJ7NU6BN-HX3tk78vF6Of4AUbOecg |
link.rule.ids | 230,315,786,790,891,12083,12250,12792,21416,27955,27956,31752,31753,33299,33300,33406,33407,33777,33778,43343,43612,43633,43838,74100,74369,74390,74657 |
linkProvider | ProQuest |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3db9MwELegE4IXxMZX2YCABoyHaKkdf-QJFbSpg61CpZP2Fjmxs1Xakm5p_3_uErdLSlX62Dtf3Zx9vvjufkfIPs10ZhWvkI8VhhmFHxmtfJYY7PQQGmqwwPlsKAbn4c8LfuEu3EqXVrmwiZWhNkWKd-SH4PizUGJY6Nv01seuURhddS00HpIthNxUHbL1_Wj4e3Sf5LGCw-wq9AKmDmvgTDjeeK91Jq1a5sbRtJo2uRI7rY6k42fkqfMlvX6t_G3ywOY75FGV05mWO2Tb7dvSO3Dg0l-fk_F1no6GfX_R_Hbm3Vgs_p2UN6VXZJ5GAANYVD5YQjuFF3Lfu6vb1VvjwffWw0qI-h7Xc8ld5Qtyfnw0_jHwXWcFP1VSznyZipAn4KlppSmspUSZXppGWhiqVaCtsJnQMgkyCR-tRdX2W3KbMSM51SF7STp5kdvXxMtMoHuaUQuOUmiSXqS4BS-SMapZpIzpkv3Fs42nNYBGXAW-mYobKuiSj_jcY4SkyDHn5VLPyzI--TOK-3DQVtFcuolJcHB1YQmEXfLFMWUFqCnVrs4ApotQVy1x_-FsyNxtcabTyW3ckLOG2hj7uUW9rDW-bjqbGRsS91qMYBDSlpx15OboxdKOnb0q4_vd1SUflmQciTl4uS3myEMjbAPPxQYeIQKsVZayS17Vu2WpdcqikHMFFNnaR0sGRDpvU_LJVYV4HgYgU8HvflrsuMbU_11Mbzb_xffk8WB8dhqfngx_7ZIntGpwgrVIe6Qzu5vbt-BmzpJ3zpb8BY0tevU |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhR1db9NA7ARDIF4QG19hAwIaMB6ipne5jzyhCqg2Pio0Nqlv0SV3GZVY0i3t_8dOLl1SqpLH2udcY5_txF-EHNJc51bxuvOxwjCjCGKjVcBSg5MeIkMNFjj_mIjj8-jrlE9d_lPl0ipbnVgralNm-I18AI4_iySGhQa5S4v4-Xn8cX4V4AQpjLS6cRq3yR2wkiGOcZBTeZPusdaR2dXqhUwNmhaaYOj4sGed1nV0x0itJ1CuRVFr4zR-SB44r9IfNWKwS27ZYo_crbM7s2qP7LoTXPlHrs30h0fk7E-RnU5GQTsGd-FfWiwDnlWXlV_mvsZWBiBeAehEO4dX88C_bgbXW-PD79bHmojmi67v0ryqx-R8_OXs03HgZiwEmZJyEchMRDwFn00rTUGqUmWGWRZrYahWobbC5kLLNMwlXFqLegC45DZnRnKqI_aE7BRlYZ8RPzehHmpGLbhMkUmHseIW_EnGqGaxMsYjh-2zTeZNK42kDoEzlXRY4JE3-NwTbE5RIJsv9LKqkpNfp8kITG4d16XbkAQHpxckL_LIe4eUl8CmTLuKA9guNr3qkfsPZofmfg8zm8-ukg6dDdDO2nc96EXD8U3b2Y7YoXjQQwTVkPXobAJ3V7einTjNVSU358wjr1dgXInZeIUtl4hDYxwIz8UWHCFCrFqW0iNPm9Oy4jplccS5AojsnaMVAvY870OK2e-693kUAk0F933bnrjO1v8Vpufb_-Ircg-USPL9ZPJtn9yn9aQTLEo6IDuL66V9Af7mIn1ZK5K_ECV9sg |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=lncRNA-dependent+mechanisms+of+androgen-receptor-+regulated+gene+activation+programs&rft.jtitle=Nature+%28London%29&rft.au=Yang%2C+Liuqing&rft.au=Lin%2C+Chunru&rft.au=Jin%2C+Chunyu&rft.au=Yang%2C+Joy+C&rft.date=2013-08-29&rft.pub=Nature+Publishing+Group&rft.issn=0028-0836&rft.eissn=1476-4687&rft.volume=500&rft.issue=7464&rft.spage=598&rft_id=info:doi/10.1038%2Fnature12451&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=3104304051 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-0836&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-0836&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-0836&client=summon |