Crystal Structure of the Malaria Vaccine Candidate Apical Membrane Antigen 1

• Published in: Science (American Association for the Advancement of Science) Vol. 308; no. 5720; pp. 408 - 411
• Main Authors: Pizarro, Juan Carlos, Normand, Brigitte Vulliez-Le, Chesne-Seck, Marie-Laure, Collins, Christine R, Withers-Martinez, Chrislaine, Hackett, Fiona, Blackman, Michael J, Faber, Bart W, Remarque, Edmond J, Kocken, Clemens H. M, Thomas, Alan W, Bentley, Graham A
• Format: Journal Article
• Language: English
• Published: Washington, DC American Association for the Advancement of Science 15.04.2005; The American Association for the Advancement of Science
• Subjects: Amino Acid Motifs; Amino Acid Sequence; Animals; Antibodies, Monoclonal - immunology; Antigenic determinants; Antigens; Antigens, Protozoan - chemistry; Antigens, Protozoan - immunology; Binding Sites; Biological and medical sciences; Care and treatment; Causes of; Crystal structure; Crystallization; Crystallography, X-Ray; Crystals; Culicidae; Dams; Epitope Mapping; Epitopes; Fundamental and applied biological sciences. Psychology; Genetics; Gross domestic product; Heparin; Heparin - metabolism; Human protozoal diseases; Infectious diseases; Ligands; Literary Devices; Malaria; Malaria Vaccines; Medical research; Medical sciences; Membrane Proteins - chemistry; Membrane Proteins - immunology; Models, Molecular; Molecular Sequence Data; Parasites; Parasitic diseases; Plasmodium falciparum; Plasmodium falciparum - chemistry; Plasmodium falciparum - immunology; Plasmodium vivax; Plasmodium vivax - chemistry; Plasmodium vivax - immunology; Protein Conformation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Proteins; Protozoa; Protozoal diseases; Protozoan Proteins - chemistry; Protozoan Proteins - immunology; Receptors; Recombinant Proteins - chemistry; Sequence Alignment; Structure; Testing; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; France; Infection; Antigen; Protozoa; Plasmodium; Apicomplexa; Protozoal disease; Antigenic determinant; Malaria; Vaccine; Parasitosis; Molecular domain; Structural analysis

Apical membrane antigen 1 from Plasmodium is a leading malaria vaccine candidate. The protein is essential for host-cell invasion, but its molecular function is unknown. The crystal structure of the three domains comprising the ectoplasmic region of the antigen from P. vivax, solved at 1.8 angstrom...