Chemotherapy-induced peripheral neuropathy: evidence from genome-wide association studies and replication within multiple myeloma patients
Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate results of all previously published genome-wide association studies (GWAS) on CIPN, and to replicate them within a cohort of multiple myeloma (MM) patients. Followi...
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| Published in | BMC cancer Vol. 18; no. 1; pp. 820 - 9 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
BioMed Central Ltd
15.08.2018
BioMed Central BMC |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1471-2407 1471-2407 |
| DOI | 10.1186/s12885-018-4728-4 |
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| Abstract | Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate results of all previously published genome-wide association studies (GWAS) on CIPN, and to replicate them within a cohort of multiple myeloma (MM) patients.
Following a systematic literature search, data for CIPN associated single nucleotide polymorphisms (SNPs) with P-values< 10
were extracted; these associations were investigated within a cohort of 983 German MM patients treated with bortezomib, thalidomide or vincristine. Cases were subjects that developed CIPN grade 2-4 while controls developed no or sub-clinical CIPN. Logistic regression with additive model was used.
In total, 9 GWASs were identified from the literature on CIPN caused by different drugs (4 paclitaxel, 2 bortezomib, 1 vincristine, 1 docetaxel, and 1 oxaliplatin). Data were extracted for 526 SNPs in 109 loci. One hundred fourty-eight patients in our study population were CIPN cases (102/646 bortezomib, 17/63 thalidomide and 29/274 vincristine). In total, 13 SNPs in 9 loci were replicated in our population (p-value< 0.05). The four smallest P-values relevant to the nerve function were 0.0006 for rs8014839 (close to the FBXO33 gene), 0.004 for rs4618330 (close to the INTU gene), 0.006 for rs1903216 (close to the BCL6 gene) and 0.03 for rs4687753 (close to the IL17RB gene).
Replicated SNPs provide clues of the molecular mechanism of CIPN and can be strong candidates for further research aiming to predict the risk of CIPN in clinical practice, particularly rs8014839, rs4618330, rs1903216, and rs4687753, which showed relevance to the function of nervous system. |
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| AbstractList | Abstract Background Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate results of all previously published genome-wide association studies (GWAS) on CIPN, and to replicate them within a cohort of multiple myeloma (MM) patients. Methods Following a systematic literature search, data for CIPN associated single nucleotide polymorphisms (SNPs) with P-values< 10− 5 were extracted; these associations were investigated within a cohort of 983 German MM patients treated with bortezomib, thalidomide or vincristine. Cases were subjects that developed CIPN grade 2–4 while controls developed no or sub-clinical CIPN. Logistic regression with additive model was used. Results In total, 9 GWASs were identified from the literature on CIPN caused by different drugs (4 paclitaxel, 2 bortezomib, 1 vincristine, 1 docetaxel, and 1 oxaliplatin). Data were extracted for 526 SNPs in 109 loci. One hundred fourty-eight patients in our study population were CIPN cases (102/646 bortezomib, 17/63 thalidomide and 29/274 vincristine). In total, 13 SNPs in 9 loci were replicated in our population (p-value< 0.05). The four smallest P-values relevant to the nerve function were 0.0006 for rs8014839 (close to the FBXO33 gene), 0.004 for rs4618330 (close to the INTU gene), 0.006 for rs1903216 (close to the BCL6 gene) and 0.03 for rs4687753 (close to the IL17RB gene). Conclusions Replicated SNPs provide clues of the molecular mechanism of CIPN and can be strong candidates for further research aiming to predict the risk of CIPN in clinical practice, particularly rs8014839, rs4618330, rs1903216, and rs4687753, which showed relevance to the function of nervous system. The figure illustrates the reasons for excluding studies Table 2 The details of all included studies Reference Year Sample size case/controls Ethnicity Chemotherapy agent Source of data Genotyping Cancer site Magrangeas 2016 155/314 European Bortezomib RCT SNP 6.0 Affymetrix arrays Multiple myeloma García-Sanz 2016 33/139 NA Bortezomib and/or thalidomide RCT Axiom Exome Genotyping array (Affymetrix) Multiple myeloma Hertz 2016 50/566 Caucasian Docetaxel RCT HumanHap610-Quad Genotyping BeadChip (Illumina) Prostate cancer Komatsu 2015 24/121 Asian Paclitaxel Cohort study Illumina Omni-Express BeadChip Cancer (NS) Schneider 2015 576/781 European Paclitaxel RCT HumanOmni1-Quad array (Illumina) Breast cancer Diouf 2015 86/235 Mixed population Vincristine RCT Affymetrix GeneChip Human Mapping 500 K array 532,552 SNPs) or the SNP 6.0 array (906,600 SNPs) (Affymetrix) Acute lymphoblastic leukemia (ALL) Leandro-García 2013 144 Cox regression European Paclitaxel Cohort study Infinium BeadChip Human 660WQuad assay (Illumina) Cancer (NS) Baldwin 2012 855 cox regression European Paclitaxel RCT HumanHap610-Quad Genotyping BeadChip (Illumina) Breast cancer Won 2011 39/57 Asian Oxaliplatin Cohort study Affymetrix Genome-Wide Human SNP Array 6.0 Colon cancer NA not available, RCT randomized control trial, NS not specified All selected SNPs were investigated in a population of 983 MM patients out of which 148 subjects developed the clinically relevant peripheral neuropathy grade 2 or higher. Table 4 In silico predictions for the significantly associated variants replicated in this study Reference Locus SNP Annotated Gene (RefSeq) Annotated Gene (GENCODE) No. of SNPs with r2 > 0.8 Promoter Histone Marks Enhancer Histone Marks DNAse Motifs changed eQTLhits RelevanteQTL tissue1(Correlatedgene) Relevant P-value of eQTL1 Relevant eQTL tissue2 (Correlated gene) Relevant P-value of eQTL2 Diouf 14q21.1 rs8014839 FBXO33 CTAGE5 3 8 tissues (Brain) 13 tissues (Brain) Skin, Liver, MUS, VAS 2 altered motifs 4 hits Blood (CTAGE5) 4.68 × 10−54 Blood (TRAPPC6B) 2.80 × 10−43 Diouf 4q28.1 rs4618330 INTU RP11-123G5.1 11 MUS 12 altered motifs – – – Baldwin 3q27.3 rs1903216 BCL6 RP11-44H4.1 1 GI 5 tissues 5 altered motifs – – – Diouf 3p14.2 rs35558909 FHIT FHIT 2 ESDR, Blood 6 altered motifs – – – Diouf 3p21.1 rs4687753 IL17RB IL17RB 49 Breast ESDR, Blood, Brain 8 altered motifs 53 hits Tibial nerve (ACTR8) 1.78 × 10−12 Tibial nerve (CHDH) 1.06 × 10−7 Diouf 8q24.12 rs7817522 DEPTOR DEPTOR 11 IPSC, Fat, GI GI, Brain ESDR, MUS 1 altered motifs 5 hits Brain (DEPTOR) 8.06 × 10−6 Esophagus Muscularis (DEPTOR) 6.43 × 10− 7 Schneider 15q21.3 rs2062640 UNC13C UNC13C 23 – – – – – Diouf 2q33.3 rs11694118 LOC100507443 snoU13 27 STRM Placenta, Brain 1 altered motifs Diouf 5q23.2 rs6891783 ZNF608 CTD-2308B18.3 38 IPSC, Lung, Brain STRM, Fat, MUS, THYM Lung 2 altered motifs – – – – – Functional annotations from the ENCODE based HaploReg v4.1 tool (http://www.broadinstitute.org/mammals/haploreg/haploreg.php) and eQTL analysis according to GTEx Portal (http://www.gtexportal.org/home/) Chr Chromosome, SNP Single nucleotide polymorphism, LD Linkage disequilibrium, eQTL Expression quantitative trait loci, DNAse deoxyribonuclease, MUS Skletal muscle, VAS Vascular system, GI Gastro intestinal system, ESDR Embryonic stem cell derivatives, ESC Embryonic stem cells, IPSC Induced pluripotent stem cells, STRM Mesenchymal stem cell derived chondrocyte cultured cells The 14q21.1 locus contains 2 replicated SNPs (rs8014839 and rs9806038). rs8014839 is the most significantly replicated SNP in this region, covering several genes including FBXO33 (F-box protein 33), CTAGE5 (cutaneous T-cell lymphoma-associated antigen, family member 5), TRAPPC6B (trafficking protein particle complex 6B), PNN (pinin, desmosome associated protein), and MIA2 (melanoma inhibitory activity 2). The population of this latter study was slightly different from the original GWAS both in distribution of menopausal status (as an age indicator) and HER2 (human epidermal growth factor receptor 2) status while in several study populations the association between age and CIPN has been reported [19, 37, 38]. [...]a part of unsuccessful replication could be explained by the interaction between the effect of age and genetic variants. To the best of our knowledge, this study is the first genetic association study that tries to aggregate results from all GWASs on CIPN and replicate them in an independent and relatively large population. Since we used the data from clinical trials, the quality of phenotype evaluation was high standard. Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate results of all previously published genome-wide association studies (GWAS) on CIPN, and to replicate them within a cohort of multiple myeloma (MM) patients. Following a systematic literature search, data for CIPN associated single nucleotide polymorphisms (SNPs) with P-values< 10.sup.- 5 were extracted; these associations were investigated within a cohort of 983 German MM patients treated with bortezomib, thalidomide or vincristine. Cases were subjects that developed CIPN grade 2-4 while controls developed no or sub-clinical CIPN. Logistic regression with additive model was used. In total, 9 GWASs were identified from the literature on CIPN caused by different drugs (4 paclitaxel, 2 bortezomib, 1 vincristine, 1 docetaxel, and 1 oxaliplatin). Data were extracted for 526 SNPs in 109 loci. One hundred fourty-eight patients in our study population were CIPN cases (102/646 bortezomib, 17/63 thalidomide and 29/274 vincristine). In total, 13 SNPs in 9 loci were replicated in our population (p-value< 0.05). The four smallest P-values relevant to the nerve function were 0.0006 for rs8014839 (close to the FBXO33 gene), 0.004 for rs4618330 (close to the INTU gene), 0.006 for rs1903216 (close to the BCL6 gene) and 0.03 for rs4687753 (close to the IL17RB gene). Replicated SNPs provide clues of the molecular mechanism of CIPN and can be strong candidates for further research aiming to predict the risk of CIPN in clinical practice, particularly rs8014839, rs4618330, rs1903216, and rs4687753, which showed relevance to the function of nervous system. Background: Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate results of all previously published genome-wide association studies (GWAS) on CIPN, and to replicate them within a cohort of multiple myeloma (MM) patients. Methods: Following a systematic literature search, data for CIPN associated single nucleotide polymorphisms (SNPs) with P-values<10-5 were extracted; these associations were investigated within a cohort of 983 German MM patients treated with bortezomib, thalidomide or vincristine. Cases were subjects that developed CIPN grade 2-4 while controls developed no or sub-clinical CIPN. Logistic regression with additive model was used. Results: In total, 9 GWASs were identified from the literature on CIPN caused by different drugs (4 paclitaxel, 2 bortezomib, 1 vincristine, 1 docetaxel, and 1 oxaliplatin). Data were extracted for 526 SNPs in 109 loci. One hundred fourty-eight patients in our study population were CIPN cases (102/646 bortezomib, 17/63 thalidomide and 29/274 vincristine). In total, 13 SNPs in 9 loci were replicated in our population (p-value< 0.05). The four smallest P-values relevant to the nerve function were 0.0006 for rs8014839 (close to the FBXO33 gene), 0.004 for rs4618330 (close to the INTU gene), 0.006 for rs1903216 (close to the BCL6 gene) and 0.03 for rs4687753 (close to the IL17RB gene). Conclusions: Replicated SNPs provide clues of the molecular mechanism of CIPN and can be strong candidates for further research aiming to predict the risk of CIPN in clinical practice, particularly rs8014839, rs4618330, rs1903216, and rs4687753, which showed relevance to the function of nervous system. Background Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate results of all previously published genome-wide association studies (GWAS) on CIPN, and to replicate them within a cohort of multiple myeloma (MM) patients. Methods Following a systematic literature search, data for CIPN associated single nucleotide polymorphisms (SNPs) with P-values< 10.sup.- 5 were extracted; these associations were investigated within a cohort of 983 German MM patients treated with bortezomib, thalidomide or vincristine. Cases were subjects that developed CIPN grade 2-4 while controls developed no or sub-clinical CIPN. Logistic regression with additive model was used. Results In total, 9 GWASs were identified from the literature on CIPN caused by different drugs (4 paclitaxel, 2 bortezomib, 1 vincristine, 1 docetaxel, and 1 oxaliplatin). Data were extracted for 526 SNPs in 109 loci. One hundred fourty-eight patients in our study population were CIPN cases (102/646 bortezomib, 17/63 thalidomide and 29/274 vincristine). In total, 13 SNPs in 9 loci were replicated in our population (p-value< 0.05). The four smallest P-values relevant to the nerve function were 0.0006 for rs8014839 (close to the FBXO33 gene), 0.004 for rs4618330 (close to the INTU gene), 0.006 for rs1903216 (close to the BCL6 gene) and 0.03 for rs4687753 (close to the IL17RB gene). Conclusions Replicated SNPs provide clues of the molecular mechanism of CIPN and can be strong candidates for further research aiming to predict the risk of CIPN in clinical practice, particularly rs8014839, rs4618330, rs1903216, and rs4687753, which showed relevance to the function of nervous system. Keywords: GWAS, Chemotherapy, Neuropathy, Multiple myeloma, Adverse drug reaction Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate results of all previously published genome-wide association studies (GWAS) on CIPN, and to replicate them within a cohort of multiple myeloma (MM) patients. Following a systematic literature search, data for CIPN associated single nucleotide polymorphisms (SNPs) with P-values< 10 were extracted; these associations were investigated within a cohort of 983 German MM patients treated with bortezomib, thalidomide or vincristine. Cases were subjects that developed CIPN grade 2-4 while controls developed no or sub-clinical CIPN. Logistic regression with additive model was used. In total, 9 GWASs were identified from the literature on CIPN caused by different drugs (4 paclitaxel, 2 bortezomib, 1 vincristine, 1 docetaxel, and 1 oxaliplatin). Data were extracted for 526 SNPs in 109 loci. One hundred fourty-eight patients in our study population were CIPN cases (102/646 bortezomib, 17/63 thalidomide and 29/274 vincristine). In total, 13 SNPs in 9 loci were replicated in our population (p-value< 0.05). The four smallest P-values relevant to the nerve function were 0.0006 for rs8014839 (close to the FBXO33 gene), 0.004 for rs4618330 (close to the INTU gene), 0.006 for rs1903216 (close to the BCL6 gene) and 0.03 for rs4687753 (close to the IL17RB gene). Replicated SNPs provide clues of the molecular mechanism of CIPN and can be strong candidates for further research aiming to predict the risk of CIPN in clinical practice, particularly rs8014839, rs4618330, rs1903216, and rs4687753, which showed relevance to the function of nervous system. Background: Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate results of all previously published genome-wide association studies (GWAS) on CIPN, and to replicate them within a cohort of multiple myeloma (MM) patients. Methods: Following a systematic literature search, data for CIPN associated single nucleotide polymorphisms (SNPs) with P-values<10-5 were extracted; these associations were investigated within a cohort of 983 German MM patients treated with bortezomib, thalidomide or vincristine. Cases were subjects that developed CIPN grade 2-4 while controls developed no or sub-clinical CIPN. Logistic regression with additive model was used. Results: In total, 9 GWASs were identified from the literature on CIPN caused by different drugs (4 paclitaxel, 2 bortezomib, 1 vincristine, 1 docetaxel, and 1 oxaliplatin). Data were extracted for 526 SNPs in 109 loci. One hundred fourty-eight patients in our study population were CIPNcases (102/646 bortezomib, 17/63 thalidomide and 29/274 vincristine). In total, 13 SNPs in 9 loci were replicated in our population (p-value< 0.05). The four smallest P-values relevant to the nerve function were 0.0006 for rs8014839 (close to the FBXO33 gene), 0.004 for rs4618330 (close to the INTU gene), 0.006 for rs1903216 (close to the BCL6 gene) and 0.03 for rs4687753 (close to the IL17RB gene). Conclusions: Replicated SNPs provide clues of the molecular mechanism of CIPN and can be strong candidates for further research aiming to predict the risk of CIPN in clinical practice, particularly rs8014839, rs4618330, rs1903216, and rs4687753, which showed relevance to the function of nervous system. Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate results of all previously published genome-wide association studies (GWAS) on CIPN, and to replicate them within a cohort of multiple myeloma (MM) patients.BACKGROUNDBased on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate results of all previously published genome-wide association studies (GWAS) on CIPN, and to replicate them within a cohort of multiple myeloma (MM) patients.Following a systematic literature search, data for CIPN associated single nucleotide polymorphisms (SNPs) with P-values< 10- 5 were extracted; these associations were investigated within a cohort of 983 German MM patients treated with bortezomib, thalidomide or vincristine. Cases were subjects that developed CIPN grade 2-4 while controls developed no or sub-clinical CIPN. Logistic regression with additive model was used.METHODSFollowing a systematic literature search, data for CIPN associated single nucleotide polymorphisms (SNPs) with P-values< 10- 5 were extracted; these associations were investigated within a cohort of 983 German MM patients treated with bortezomib, thalidomide or vincristine. Cases were subjects that developed CIPN grade 2-4 while controls developed no or sub-clinical CIPN. Logistic regression with additive model was used.In total, 9 GWASs were identified from the literature on CIPN caused by different drugs (4 paclitaxel, 2 bortezomib, 1 vincristine, 1 docetaxel, and 1 oxaliplatin). Data were extracted for 526 SNPs in 109 loci. One hundred fourty-eight patients in our study population were CIPN cases (102/646 bortezomib, 17/63 thalidomide and 29/274 vincristine). In total, 13 SNPs in 9 loci were replicated in our population (p-value< 0.05). The four smallest P-values relevant to the nerve function were 0.0006 for rs8014839 (close to the FBXO33 gene), 0.004 for rs4618330 (close to the INTU gene), 0.006 for rs1903216 (close to the BCL6 gene) and 0.03 for rs4687753 (close to the IL17RB gene).RESULTSIn total, 9 GWASs were identified from the literature on CIPN caused by different drugs (4 paclitaxel, 2 bortezomib, 1 vincristine, 1 docetaxel, and 1 oxaliplatin). Data were extracted for 526 SNPs in 109 loci. One hundred fourty-eight patients in our study population were CIPN cases (102/646 bortezomib, 17/63 thalidomide and 29/274 vincristine). In total, 13 SNPs in 9 loci were replicated in our population (p-value< 0.05). The four smallest P-values relevant to the nerve function were 0.0006 for rs8014839 (close to the FBXO33 gene), 0.004 for rs4618330 (close to the INTU gene), 0.006 for rs1903216 (close to the BCL6 gene) and 0.03 for rs4687753 (close to the IL17RB gene).Replicated SNPs provide clues of the molecular mechanism of CIPN and can be strong candidates for further research aiming to predict the risk of CIPN in clinical practice, particularly rs8014839, rs4618330, rs1903216, and rs4687753, which showed relevance to the function of nervous system.CONCLUSIONSReplicated SNPs provide clues of the molecular mechanism of CIPN and can be strong candidates for further research aiming to predict the risk of CIPN in clinical practice, particularly rs8014839, rs4618330, rs1903216, and rs4687753, which showed relevance to the function of nervous system. |
| ArticleNumber | 820 |
| Audience | Academic |
| Author | Merz, Maximilian Mahmoudpour, Seyed Hamidreza Hemminki, Kari Bandapalli, Obul Reddy Goldschmidt, Hartmut Campo, Chiara da Silva Filho, Miguel Inácio Försti, Asta |
| Author_xml | – sequence: 1 givenname: Seyed Hamidreza orcidid: 0000-0001-5575-4238 surname: Mahmoudpour fullname: Mahmoudpour, Seyed Hamidreza – sequence: 2 givenname: Obul Reddy surname: Bandapalli fullname: Bandapalli, Obul Reddy – sequence: 3 givenname: Miguel Inácio surname: da Silva Filho fullname: da Silva Filho, Miguel Inácio – sequence: 4 givenname: Chiara surname: Campo fullname: Campo, Chiara – sequence: 5 givenname: Kari surname: Hemminki fullname: Hemminki, Kari – sequence: 6 givenname: Hartmut surname: Goldschmidt fullname: Goldschmidt, Hartmut – sequence: 7 givenname: Maximilian surname: Merz fullname: Merz, Maximilian – sequence: 8 givenname: Asta surname: Försti fullname: Försti, Asta |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30111286$$D View this record in MEDLINE/PubMed https://lup.lub.lu.se/record/6fece220-7cc6-4556-91cd-9e7bd13850d8$$DView record from Swedish Publication Index oai:portal.research.lu.se:publications/6fece220-7cc6-4556-91cd-9e7bd13850d8$$DView record from Swedish Publication Index |
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| Cites_doi | 10.12659/MSM.902906 10.1523/JNEUROSCI.4774-12.2013 10.1038/ng.2756 10.1038/leu.2015.80 10.1158/1078-0432.CCR-15-2823 10.1038/sj.embor.7400463 10.1158/1078-0432.CCR-16-3224 10.1093/nar/gkr917 10.1016/j.ygyno.2015.11.011 10.1371/journal.pone.0108354 10.1016/j.pain.2014.09.020 10.1016/j.molmed.2014.03.001 10.1093/nar/29.1.308 10.1136/jmedgenet-2012-101466 10.1200/JCO.2015.66.2346 10.1007/s11064-016-2007-9 10.1158/1078-0432.CCR-15-0586 10.1001/jama.2015.0894 10.1093/nar/gkj143 10.1038/ng.2733 10.1200/JCO.2011.39.6820 10.1158/1078-0432.CCR-13-3232 10.1164/rccm.201304-0754PP 10.1002/cam4.625 10.1091/mbc.e11-02-0143 10.1126/science.1262110 10.1371/journal.pgen.1000529 10.1007/s00277-003-0685-2 10.1093/annonc/mdx096 10.1002/cncr.26614 10.1158/1078-0432.CCR-15-0133 10.1093/nar/gkt1249 10.1097/00125817-200203000-00002 10.1101/gr.137323.112 10.1371/journal.pone.0070903 10.1038/npp.2014.267 10.1158/1078-0432.CCR-15-3163 10.1056/NEJMoa1505067 10.1016/S1470-2045(11)70081-X 10.1002/hon.2337 10.1093/beheco/arh107 10.3892/ol.2015.3376 10.1016/j.jns.2014.12.041 10.1158/1078-0432.CCR-12-1590 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2018 BioMed Central Ltd. Copyright © 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and conditions, you may use this content in accordance with the terms of the License. The Author(s). 2018 |
| Copyright_xml | – notice: COPYRIGHT 2018 BioMed Central Ltd. – notice: Copyright © 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and conditions, you may use this content in accordance with the terms of the License. – notice: The Author(s). 2018 |
| CorporateAuthor | Lunds universitet Profile areas and other strong research environments Department of Clinical Sciences, Malmö Lund University Strategiska forskningsområden (SFO) EpiHealth: Epidemiology for Health Faculty of Medicine Family Medicine and Clinical Epidemiology Allmänmedicin och klinisk epidemiologi Strategic research areas (SRA) Medicinska fakulteten Profilområden och andra starka forskningsmiljöer Institutionen för kliniska vetenskaper, Malmö |
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| DOI | 10.1186/s12885-018-4728-4 |
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| Keywords | Chemotherapy GWAS Adverse drug reaction Neuropathy Multiple myeloma |
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| References | AP Boyle (4728_CR15) 2012; 22 SR Stott (4728_CR33) 2013; 33 JR Brewer (4728_CR2) 2016; 140 JN Hirschhorn (4728_CR6) 2002; 4 ME Dolan (4728_CR37) 2017; 23 HJ Westra (4728_CR26) 2013; 45 D Kummel (4728_CR31) 2005; 6 B Diouf (4728_CR22) 2015; 313 P Moreau (4728_CR45) 2011; 12 DL Hershman (4728_CR38) 2016; 34 C Campo (4728_CR5) 2017; 42 F Magrangeas (4728_CR21) 2016; 22 DL Hertz (4728_CR23) 2016; 22 BN Howie (4728_CR13) 2009; 5 P Sonneveld (4728_CR8) 2012; 30 HH Won (4728_CR24) 2012; 118 RM Baldwin (4728_CR16) 2012; 18 P Zhu (4728_CR35) 2015; 10 GT Consortium (4728_CR41) 2015; 348 A Osakabe (4728_CR42) 2014; 9 C Sanchez-Mora (4728_CR28) 2015; 40 P Kheradpour (4728_CR32) 2014; 42 BP Schneider (4728_CR19) 2015; 21 SH Mahmoudpour (4728_CR25) 2017; 26 M Seretny (4728_CR1) 2014; 155 R Garcia-Sanz (4728_CR20) 2017; 35 GK Boora (4728_CR4) 2016; 5 P Moreau (4728_CR12) 2017; 28 M Komatsu (4728_CR17) 2015; 21 C Johnson (4728_CR3) 2015; 349 ST Sherry (4728_CR7) 2001; 29 SJ Ahonen (4728_CR29) 2013; 8 K Liu (4728_CR34) 2017; 23 EK Mai (4728_CR10) 2015; 29 LD Ward (4728_CR14) 2012; 40 JE Abraham (4728_CR36) 2014; 20 S Nakagawa (4728_CR44) 2004; 15 H Goldschmidt (4728_CR9) 2003; 82 V Matys (4728_CR43) 2006; 34 D Chubb (4728_CR11) 2013; 45 K Saito (4728_CR30) 2011; 22 JK Chan (4728_CR39) 2016; 374 LJ Leandro-Garcia (4728_CR18) 2013; 50 K Hatzi (4728_CR40) 2014; 20 NM Weathington (4728_CR27) 2013; 188 22843789 - Clin Cancer Res. 2012 Sep 15;18(18):5099-109 21525241 - Mol Biol Cell. 2011 Jul 1;22(13):2301-8 24599932 - Clin Cancer Res. 2014 May 1;20(9):2466-75 11882781 - Genet Med. 2002 Mar-Apr;4(2):45-61 12845480 - Ann Hematol. 2003 Oct;82(10):654-9 26622696 - Oncol Lett. 2015 Sep;10(3):1487-1494 25710658 - JAMA. 2015 Feb 24;313(8):815-23 27422265 - Neurochem Res. 2017 Mar;42(3):925-931 22064851 - Nucleic Acids Res. 2012 Jan;40(Database issue):D930-4 11125122 - Nucleic Acids Res. 2001 Jan 1;29(1):308-11 16381825 - Nucleic Acids Res. 2006 Jan 1;34(Database issue):D108-10 23955597 - Nat Genet. 2013 Oct;45(10):1221-1225 22020760 - Cancer. 2012 Jun 1;118(11):2828-36 25261162 - Pain. 2014 Dec;155(12):2461-70 26933849 - N Engl J Med. 2016 Feb 25;374(8):738-48 25299602 - PLoS One. 2014 Oct 09;9(10):e108354 28453614 - Ann Oncol. 2017 Jul 1;28(suppl_4):iv52-iv61 16025134 - EMBO Rep. 2005 Aug;6(8):787-93 22802322 - J Clin Oncol. 2012 Aug 20;30(24):2946-55 23776197 - J Med Genet. 2013 Sep;50(9):599-605 27605156 - Hematol Oncol. 2017 Dec;35(4):746-751 26763541 - Cancer Med. 2016 Apr;5(4):631-9 24698494 - Trends Mol Med. 2014 Jun;20(6):343-52 27143689 - Clin Cancer Res. 2016 Oct 1;22(19):4890-4900 26556766 - Gynecol Oncol. 2016 Jan;140(1):176-83 23713962 - Am J Respir Crit Care Med. 2013 Sep 1;188(5):530-7 23951034 - PLoS One. 2013 Aug 07;8(8):e70903 23637192 - J Neurosci. 2013 May 1;33(18):8022-34 22955989 - Genome Res. 2012 Sep;22(9):1790-7 25284319 - Neuropsychopharmacology. 2015 Mar;40(4):915-26 21507715 - Lancet Oncol. 2011 May;12(5):431-40 28611204 - Clin Cancer Res. 2017 Oct 1;23(19):5757-5768 25586538 - J Neurol Sci. 2015 Feb 15;349(1-2):124-8 27060151 - Clin Cancer Res. 2016 Sep 1;22(17):4350-4355 25787915 - Leukemia. 2015 Aug;29(8):1721-9 25954001 - Science. 2015 May 8;348(6235):648-60 27325863 - J Clin Oncol. 2016 Sep 1;34(25):3014-22 19543373 - PLoS Genet. 2009 Jun;5(6):e1000529 28209947 - Med Sci Monit. 2017 Feb 17;23:856-866 26015512 - Clin Cancer Res. 2015 Oct 1;21(19):4337-46 26138065 - Clin Cancer Res. 2015 Nov 15;21(22):5082-5091 24335146 - Nucleic Acids Res. 2014 Mar;42(5):2976-87 24013639 - Nat Genet. 2013 Oct;45(10):1238-1243 |
| References_xml | – volume: 23 start-page: 856 year: 2017 ident: 4728_CR34 publication-title: Med Sci Monit doi: 10.12659/MSM.902906 – volume: 33 start-page: 8022 issue: 18 year: 2013 ident: 4728_CR33 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.4774-12.2013 – volume: 45 start-page: 1238 issue: 10 year: 2013 ident: 4728_CR26 publication-title: Nat Genet doi: 10.1038/ng.2756 – volume: 29 start-page: 1721 issue: 8 year: 2015 ident: 4728_CR10 publication-title: Leukemia doi: 10.1038/leu.2015.80 – volume: 22 start-page: 4890 issue: 19 year: 2016 ident: 4728_CR23 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-15-2823 – volume: 6 start-page: 787 issue: 8 year: 2005 ident: 4728_CR31 publication-title: EMBO Rep doi: 10.1038/sj.embor.7400463 – volume: 23 start-page: 5757 issue: 19 year: 2017 ident: 4728_CR37 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-16-3224 – volume: 40 start-page: D930 issue: Database issue year: 2012 ident: 4728_CR14 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkr917 – volume: 140 start-page: 176 issue: 1 year: 2016 ident: 4728_CR2 publication-title: Gynecol Oncol doi: 10.1016/j.ygyno.2015.11.011 – volume: 9 start-page: e108354 issue: 10 year: 2014 ident: 4728_CR42 publication-title: PLoS One doi: 10.1371/journal.pone.0108354 – volume: 155 start-page: 2461 issue: 12 year: 2014 ident: 4728_CR1 publication-title: Pain doi: 10.1016/j.pain.2014.09.020 – volume: 26 start-page: 275 issue: Suppl. 2 year: 2017 ident: 4728_CR25 publication-title: Pharmacoepidemiol Drug Saf – volume: 20 start-page: 343 issue: 6 year: 2014 ident: 4728_CR40 publication-title: Trends Mol Med doi: 10.1016/j.molmed.2014.03.001 – volume: 29 start-page: 308 issue: 1 year: 2001 ident: 4728_CR7 publication-title: Nucleic Acids Res doi: 10.1093/nar/29.1.308 – volume: 50 start-page: 599 issue: 9 year: 2013 ident: 4728_CR18 publication-title: J Med Genet doi: 10.1136/jmedgenet-2012-101466 – volume: 34 start-page: 3014 issue: 25 year: 2016 ident: 4728_CR38 publication-title: J Clin Oncol doi: 10.1200/JCO.2015.66.2346 – volume: 42 start-page: 925 issue: 3 year: 2017 ident: 4728_CR5 publication-title: Neurochem Res doi: 10.1007/s11064-016-2007-9 – volume: 21 start-page: 5082 issue: 22 year: 2015 ident: 4728_CR19 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-15-0586 – volume: 313 start-page: 815 issue: 8 year: 2015 ident: 4728_CR22 publication-title: JAMA doi: 10.1001/jama.2015.0894 – volume: 34 start-page: D108 issue: Database issue year: 2006 ident: 4728_CR43 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkj143 – volume: 45 start-page: 1221 issue: 10 year: 2013 ident: 4728_CR11 publication-title: Nat Genet doi: 10.1038/ng.2733 – volume: 30 start-page: 2946 issue: 24 year: 2012 ident: 4728_CR8 publication-title: J Clin Oncol doi: 10.1200/JCO.2011.39.6820 – volume: 20 start-page: 2466 issue: 9 year: 2014 ident: 4728_CR36 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-13-3232 – volume: 188 start-page: 530 issue: 5 year: 2013 ident: 4728_CR27 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201304-0754PP – volume: 5 start-page: 631 issue: 4 year: 2016 ident: 4728_CR4 publication-title: Cancer Med doi: 10.1002/cam4.625 – volume: 22 start-page: 2301 issue: 13 year: 2011 ident: 4728_CR30 publication-title: Mol Biol Cell doi: 10.1091/mbc.e11-02-0143 – volume: 348 start-page: 648 issue: 6235 year: 2015 ident: 4728_CR41 publication-title: Science doi: 10.1126/science.1262110 – volume: 5 start-page: e1000529 issue: 6 year: 2009 ident: 4728_CR13 publication-title: PLoS Genet doi: 10.1371/journal.pgen.1000529 – volume: 82 start-page: 654 issue: 10 year: 2003 ident: 4728_CR9 publication-title: Ann Hematol doi: 10.1007/s00277-003-0685-2 – volume: 28 start-page: iv52 issue: suppl_4 year: 2017 ident: 4728_CR12 publication-title: Ann Oncol doi: 10.1093/annonc/mdx096 – volume: 118 start-page: 2828 issue: 11 year: 2012 ident: 4728_CR24 publication-title: Cancer doi: 10.1002/cncr.26614 – volume: 21 start-page: 4337 issue: 19 year: 2015 ident: 4728_CR17 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-15-0133 – volume: 42 start-page: 2976 issue: 5 year: 2014 ident: 4728_CR32 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkt1249 – volume: 4 start-page: 45 issue: 2 year: 2002 ident: 4728_CR6 publication-title: Genet Med doi: 10.1097/00125817-200203000-00002 – volume: 22 start-page: 1790 issue: 9 year: 2012 ident: 4728_CR15 publication-title: Genome Res doi: 10.1101/gr.137323.112 – volume: 8 start-page: e70903 issue: 8 year: 2013 ident: 4728_CR29 publication-title: PLoS One doi: 10.1371/journal.pone.0070903 – volume: 40 start-page: 915 issue: 4 year: 2015 ident: 4728_CR28 publication-title: Neuropsychopharmacology doi: 10.1038/npp.2014.267 – volume: 22 start-page: 4350 issue: 17 year: 2016 ident: 4728_CR21 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-15-3163 – volume: 374 start-page: 738 issue: 8 year: 2016 ident: 4728_CR39 publication-title: N Engl J Med doi: 10.1056/NEJMoa1505067 – volume: 12 start-page: 431 issue: 5 year: 2011 ident: 4728_CR45 publication-title: Lancet Oncol doi: 10.1016/S1470-2045(11)70081-X – volume: 35 start-page: 746 issue: 4 year: 2017 ident: 4728_CR20 publication-title: Hematol Oncol doi: 10.1002/hon.2337 – volume: 15 start-page: 1044 issue: 6 year: 2004 ident: 4728_CR44 publication-title: Behavioral Ecol doi: 10.1093/beheco/arh107 – volume: 10 start-page: 1487 issue: 3 year: 2015 ident: 4728_CR35 publication-title: Oncol Lett doi: 10.3892/ol.2015.3376 – volume: 349 start-page: 124 issue: 1–2 year: 2015 ident: 4728_CR3 publication-title: J Neurol Sci doi: 10.1016/j.jns.2014.12.041 – volume: 18 start-page: 5099 issue: 18 year: 2012 ident: 4728_CR16 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-12-1590 – reference: 27422265 - Neurochem Res. 2017 Mar;42(3):925-931 – reference: 28453614 - Ann Oncol. 2017 Jul 1;28(suppl_4):iv52-iv61 – reference: 23713962 - Am J Respir Crit Care Med. 2013 Sep 1;188(5):530-7 – reference: 23951034 - PLoS One. 2013 Aug 07;8(8):e70903 – reference: 25787915 - Leukemia. 2015 Aug;29(8):1721-9 – reference: 28611204 - Clin Cancer Res. 2017 Oct 1;23(19):5757-5768 – reference: 21507715 - Lancet Oncol. 2011 May;12(5):431-40 – reference: 26933849 - N Engl J Med. 2016 Feb 25;374(8):738-48 – reference: 22064851 - Nucleic Acids Res. 2012 Jan;40(Database issue):D930-4 – reference: 12845480 - Ann Hematol. 2003 Oct;82(10):654-9 – reference: 16381825 - Nucleic Acids Res. 2006 Jan 1;34(Database issue):D108-10 – reference: 25954001 - Science. 2015 May 8;348(6235):648-60 – reference: 19543373 - PLoS Genet. 2009 Jun;5(6):e1000529 – reference: 22843789 - Clin Cancer Res. 2012 Sep 15;18(18):5099-109 – reference: 26556766 - Gynecol Oncol. 2016 Jan;140(1):176-83 – reference: 27605156 - Hematol Oncol. 2017 Dec;35(4):746-751 – reference: 26138065 - Clin Cancer Res. 2015 Nov 15;21(22):5082-5091 – reference: 24698494 - Trends Mol Med. 2014 Jun;20(6):343-52 – reference: 22802322 - J Clin Oncol. 2012 Aug 20;30(24):2946-55 – reference: 26622696 - Oncol Lett. 2015 Sep;10(3):1487-1494 – reference: 11882781 - Genet Med. 2002 Mar-Apr;4(2):45-61 – reference: 24599932 - Clin Cancer Res. 2014 May 1;20(9):2466-75 – reference: 27325863 - J Clin Oncol. 2016 Sep 1;34(25):3014-22 – reference: 25299602 - PLoS One. 2014 Oct 09;9(10):e108354 – reference: 24335146 - Nucleic Acids Res. 2014 Mar;42(5):2976-87 – reference: 22020760 - Cancer. 2012 Jun 1;118(11):2828-36 – reference: 26015512 - Clin Cancer Res. 2015 Oct 1;21(19):4337-46 – reference: 23776197 - J Med Genet. 2013 Sep;50(9):599-605 – reference: 25710658 - JAMA. 2015 Feb 24;313(8):815-23 – reference: 26763541 - Cancer Med. 2016 Apr;5(4):631-9 – reference: 23637192 - J Neurosci. 2013 May 1;33(18):8022-34 – reference: 25586538 - J Neurol Sci. 2015 Feb 15;349(1-2):124-8 – reference: 25284319 - Neuropsychopharmacology. 2015 Mar;40(4):915-26 – reference: 28209947 - Med Sci Monit. 2017 Feb 17;23:856-866 – reference: 23955597 - Nat Genet. 2013 Oct;45(10):1221-1225 – reference: 21525241 - Mol Biol Cell. 2011 Jul 1;22(13):2301-8 – reference: 16025134 - EMBO Rep. 2005 Aug;6(8):787-93 – reference: 27143689 - Clin Cancer Res. 2016 Oct 1;22(19):4890-4900 – reference: 25261162 - Pain. 2014 Dec;155(12):2461-70 – reference: 11125122 - Nucleic Acids Res. 2001 Jan 1;29(1):308-11 – reference: 24013639 - Nat Genet. 2013 Oct;45(10):1238-1243 – reference: 27060151 - Clin Cancer Res. 2016 Sep 1;22(17):4350-4355 – reference: 22955989 - Genome Res. 2012 Sep;22(9):1790-7 |
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| Snippet | Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate results of all... Background Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate results of... The figure illustrates the reasons for excluding studies Table 2 The details of all included studies Reference Year Sample size case/controls Ethnicity... Background: Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate results of... Abstract Background Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate... |
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| SubjectTerms | Adverse drug reaction Aged Analysis Basic Medicine Bortezomib - adverse effects Breast cancer Cancer and Oncology Cancer och onkologi Cancer patients Cancer therapies Care and treatment Chemotherapy Chondrocytes Clinical Medicine Clinical trials Colorectal cancer Drug-Related Side Effects and Adverse Reactions - genetics Drug-Related Side Effects and Adverse Reactions - pathology Female Genetic aspects Genome-wide association studies Genome-Wide Association Study Genomes GWAS Health aspects Humans Klinisk medicin Male Medical and Health Sciences Medical Genetics Medical Genetics and Genomics (including Gene Therapy) Medical prognosis Medical research Medicin och hälsovetenskap Medicinsk genetik Medicinsk genetik och genomik (Här ingår: Genterapi) Medicinska och farmaceutiska grundvetenskaper Middle Aged Multiple myeloma Multiple Myeloma - complications Multiple Myeloma - drug therapy Multiple Myeloma - genetics Nervous System - pathology Neuropathy Organoplatinum Compounds - adverse effects Paclitaxel - adverse effects Patients Peripheral Nervous System Diseases - chemically induced Peripheral Nervous System Diseases - genetics Peripheral Nervous System Diseases - pathology Peripheral neuropathy Pluripotency Polymorphism, Single Nucleotide - genetics Population Prostate cancer Quality of life Risk Factors Single nucleotide polymorphisms Studies Taxoids - adverse effects Vincristine - adverse effects |
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| Title | Chemotherapy-induced peripheral neuropathy: evidence from genome-wide association studies and replication within multiple myeloma patients |
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