P4141Lack of IkBNS promotes cholate-containing high-fat diet-induced inflammation and atherogenesis in low-density lipoprotein (LDL) receptor-deficient mice

• Published in: European heart journal Vol. 40; no. Supplement_1
• Main Authors: Kitamura, K, Isoda, K, Akita, K, Miyosawa, K, Kadoguchi, T, Shimada, K, Daida, H
• Format: Journal Article
• Language: English
• Published: Oxford University Press 01.10.2019
• Subjects: Basic Science - Vascular Diseases: Leukocytes, Inflammation, Immunity

Abstract Background IκBNS is one of the nuclear IκB proteins and regulates a subset of Toll-like receptor (TLR) dependent genes. LPS acts as extremely strong stimulator of innate immunity. We tried to investigate whether stimulation of innate immunity could promote atherosclerosis in the IκBNS-defic...