Menopausal hormone therapy and women’s health: An umbrella review

• Published in: PLoS medicine Vol. 18; no. 8; p. e1003731
• Main Authors: Zhang, Guo-Qiang, Chen, Jin-Liang, Luo, Ying, Mathur, Maya B., Anagnostis, Panagiotis, Nurmatov, Ulugbek, Talibov, Madar, Zhang, Jing, Hawrylowicz, Catherine M., Lumsden, Mary Ann, Critchley, Hilary, Sheikh, Aziz, Lundbäck, Bo, Lässer, Cecilia, Kankaanranta, Hannu, Lee, Siew Hwa, Nwaru, Bright I.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02.08.2021; Public Library of Science (PLoS)
• Subjects: Alzheimer's disease; Asthma; Atrophy; Brain cancer; Breast cancer; Cancer and Oncology; Cancer och onkologi; Cardiovascular disease; Cardiovascular diseases; cardiovascular risk; Cerebrovascular diseases; Clinical medicine; Colorectal cancer; Colorectal carcinoma; Complications and side effects; Diabetes mellitus; effect size; Embolism; Endocrine therapy; Endometrial cancer; Endometrium; Esophagus; Estrogen Replacement Therapy - statistics & numerical data; Estrogens; Estrogens - therapeutic use; Female; Gallbladder; General & Internal Medicine; Glioma; Gynaecology, Obstetrics and Reproductive Medicine; Gynekologi, obstetrik och reproduktionsmedicin; Health aspects; Hormone therapy; Humans; Hyperplasia; Lung cancer; Lung diseases; Medicine and Health Sciences; Meningioma; Menopause; Menopause - physiology; Meta-analysis; Middle Aged; Mortality; Neurodegenerative diseases; Observational studies; Ovarian cancer; Patient outcomes; Physical Sciences; Population; postmenopausal women; primary prevention; Progestins - therapeutic use; replacement therapy; Research and Analysis Methods; Reviews; risk-factors; Stroke; systematic; Systematic review; Thyroid; timing hypothesis; Vagina; Vertebrae; Women; Women's Health - statistics & numerical data; Womens health; Sweden

There remains uncertainty about the impact of menopausal hormone therapy (MHT) on women's health. A systematic, comprehensive assessment of the effects on multiple outcomes is lacking. We conducted an umbrella review to comprehensively summarize evidence on the benefits and harms of MHT across...