Salinomycin overcomes acquired tamoxifen resistance through AIB 1 and inhibits cancer cell invasion in endocrine resistant breast cancer

Summary Salinomycin is a monocarboxylic polyether ionophore isolated from Streptomyces albus . It has been widely used as an antibiotic in veterinary medicine in poultry. A recent study demonstrated that salinomycin selectively inhibits human breast cancer stem cells; one possible mechanism of tamox...

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Published inClinical and experimental pharmacology & physiology Vol. 44; no. 10; pp. 1042 - 1052
Main Authors Manmuan, Suwisit, Sakunrangsit, Nithidol, Ketchart, Wannarasmi
Format Journal Article
LanguageEnglish
Published 01.10.2017
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Abstract Summary Salinomycin is a monocarboxylic polyether ionophore isolated from Streptomyces albus . It has been widely used as an antibiotic in veterinary medicine in poultry. A recent study demonstrated that salinomycin selectively inhibits human breast cancer stem cells; one possible mechanism of tamoxifen resistance. Our results show that salinomycin is effective in inhibiting MCF ‐7/ LCC 2 and MCF ‐7/ LCC 9 cell lines which are well‐established endocrine resistant cells and has a synergistic effect in combination with tamoxifen using MTT proliferation assay. The inhibitory effect of salinomycin on the reduction of critical ER co‐activator; amplified breast 1 ( AIB 1 ) mRNA and protein expression is overcoming tamoxifen resistance . Moreover, salinomycin significantly inhibits cell invasion in Matrigel invasion assay. The effect was mediated at least in part by the decrease of matrix metalopeptidase 9 ( MMP ‐9) which is one critical enzyme facilitated in the cell invasion process. In conclusion, salinomycin should be developed as a novel agent used alone or in combination for endocrine‐resistant breast cancer.
AbstractList Summary Salinomycin is a monocarboxylic polyether ionophore isolated from Streptomyces albus . It has been widely used as an antibiotic in veterinary medicine in poultry. A recent study demonstrated that salinomycin selectively inhibits human breast cancer stem cells; one possible mechanism of tamoxifen resistance. Our results show that salinomycin is effective in inhibiting MCF ‐7/ LCC 2 and MCF ‐7/ LCC 9 cell lines which are well‐established endocrine resistant cells and has a synergistic effect in combination with tamoxifen using MTT proliferation assay. The inhibitory effect of salinomycin on the reduction of critical ER co‐activator; amplified breast 1 ( AIB 1 ) mRNA and protein expression is overcoming tamoxifen resistance . Moreover, salinomycin significantly inhibits cell invasion in Matrigel invasion assay. The effect was mediated at least in part by the decrease of matrix metalopeptidase 9 ( MMP ‐9) which is one critical enzyme facilitated in the cell invasion process. In conclusion, salinomycin should be developed as a novel agent used alone or in combination for endocrine‐resistant breast cancer.
Author Ketchart, Wannarasmi
Manmuan, Suwisit
Sakunrangsit, Nithidol
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Cites_doi 10.1016/j.canlet.2011.07.016
10.1016/j.yexmp.2006.09.001
10.1038/bjc.2011.530
10.1210/me.2011-1037
10.1016/j.bbrc.2011.08.054
10.1155/2012/950658
10.1038/nrc3090
10.1371/journal.pone.0094438
10.3390/ijms131013169
10.1016/j.bbrc.2009.10.042
10.1002/emmm.201303411
10.3816/CBC.2009.s.001
10.1200/JCO.2002.06.020
10.1016/j.canlet.2011.05.030
10.1186/1477-7819-9-139
10.1007/s00109-014-1155-0
10.1038/cddis.2013.515
10.1016/j.ejphar.2012.11.071
10.1158/0008-5472.CAN-09-1947
10.3390/ijms14010108
10.1371/journal.pone.0060889
10.1016/j.pan.2012.11.314
10.1016/j.bbrc.2015.09.108
10.3892/mmr.2014.2766
10.1016/j.ygyno.2013.03.005
10.1016/j.cell.2009.06.034
10.1073/pnas.0710887105
10.1038/onc.2012.405
10.3322/caac.21166
10.1016/j.bbagen.2013.01.010
10.2174/15672050113109990199
10.1155/2009/904836
10.1002/mc.20721
10.1200/JCO.2002.20.4.1026
10.1016/j.bcmd.2010.03.008
10.1002/ijc.10269
10.1016/j.toxlet.2013.07.022
10.1007/s10549-010-0870-7
10.1056/NEJMra050776
10.1371/journal.pone.0066931
10.1016/j.cell.2011.11.016
10.1016/j.bbrc.2011.12.141
10.1007/978-1-61779-012-6_9
10.1371/journal.pone.0050638
10.1016/j.mrfmmm.2005.02.028
10.1093/annonc/mdt159
10.1016/j.cbi.2014.12.002
10.1007/s10549-013-2563-5
10.18632/oncotarget.10459
10.1007/s10549-013-2406-4
10.1007/s10549-015-3376-5
10.1038/nrc2657
10.1016/j.jsbmb.2006.09.028
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References e_1_2_7_5_1
e_1_2_7_3_1
e_1_2_7_9_1
e_1_2_7_7_1
e_1_2_7_19_1
e_1_2_7_17_1
e_1_2_7_15_1
e_1_2_7_41_1
e_1_2_7_13_1
e_1_2_7_43_1
e_1_2_7_11_1
e_1_2_7_45_1
e_1_2_7_47_1
e_1_2_7_26_1
e_1_2_7_49_1
e_1_2_7_28_1
e_1_2_7_50_1
e_1_2_7_25_1
e_1_2_7_31_1
e_1_2_7_52_1
e_1_2_7_23_1
e_1_2_7_33_1
e_1_2_7_54_1
e_1_2_7_21_1
e_1_2_7_35_1
e_1_2_7_37_1
e_1_2_7_39_1
e_1_2_7_6_1
e_1_2_7_4_1
e_1_2_7_8_1
e_1_2_7_18_1
e_1_2_7_16_1
e_1_2_7_40_1
e_1_2_7_2_1
e_1_2_7_14_1
e_1_2_7_42_1
e_1_2_7_12_1
e_1_2_7_44_1
e_1_2_7_10_1
e_1_2_7_46_1
e_1_2_7_48_1
e_1_2_7_27_1
e_1_2_7_29_1
e_1_2_7_30_1
Mukherjee D (e_1_2_7_51_1) 2013; 3
e_1_2_7_53_1
e_1_2_7_24_1
e_1_2_7_32_1
e_1_2_7_55_1
e_1_2_7_22_1
e_1_2_7_34_1
e_1_2_7_20_1
e_1_2_7_36_1
e_1_2_7_38_1
References_xml – ident: e_1_2_7_19_1
  doi: 10.1016/j.canlet.2011.07.016
– ident: e_1_2_7_39_1
  doi: 10.1016/j.yexmp.2006.09.001
– ident: e_1_2_7_33_1
  doi: 10.1038/bjc.2011.530
– ident: e_1_2_7_37_1
  doi: 10.1210/me.2011-1037
– ident: e_1_2_7_22_1
  doi: 10.1016/j.bbrc.2011.08.054
– ident: e_1_2_7_17_1
  doi: 10.1155/2012/950658
– ident: e_1_2_7_35_1
  doi: 10.1038/nrc3090
– ident: e_1_2_7_26_1
  doi: 10.1371/journal.pone.0094438
– ident: e_1_2_7_21_1
  doi: 10.3390/ijms131013169
– ident: e_1_2_7_14_1
  doi: 10.1016/j.bbrc.2009.10.042
– ident: e_1_2_7_25_1
  doi: 10.1002/emmm.201303411
– ident: e_1_2_7_4_1
  doi: 10.3816/CBC.2009.s.001
– ident: e_1_2_7_12_1
  doi: 10.1200/JCO.2002.06.020
– ident: e_1_2_7_45_1
  doi: 10.1016/j.canlet.2011.05.030
– ident: e_1_2_7_47_1
  doi: 10.1186/1477-7819-9-139
– ident: e_1_2_7_27_1
  doi: 10.1007/s00109-014-1155-0
– ident: e_1_2_7_16_1
  doi: 10.1038/cddis.2013.515
– ident: e_1_2_7_6_1
  doi: 10.1016/j.ejphar.2012.11.071
– ident: e_1_2_7_54_1
  doi: 10.1158/0008-5472.CAN-09-1947
– ident: e_1_2_7_5_1
  doi: 10.3390/ijms14010108
– ident: e_1_2_7_8_1
  doi: 10.1371/journal.pone.0060889
– ident: e_1_2_7_24_1
  doi: 10.1016/j.pan.2012.11.314
– ident: e_1_2_7_29_1
  doi: 10.1016/j.bbrc.2015.09.108
– ident: e_1_2_7_44_1
  doi: 10.3892/mmr.2014.2766
– volume: 3
  start-page: 46
  year: 2013
  ident: e_1_2_7_51_1
  article-title: The Role of chemokine receptor CXCR4 in breast cancer metastasis
  publication-title: Am J Cancer Res
  contributor:
    fullname: Mukherjee D
– ident: e_1_2_7_15_1
  doi: 10.1016/j.ygyno.2013.03.005
– ident: e_1_2_7_13_1
  doi: 10.1016/j.cell.2009.06.034
– ident: e_1_2_7_43_1
  doi: 10.1073/pnas.0710887105
– ident: e_1_2_7_55_1
  doi: 10.1038/onc.2012.405
– ident: e_1_2_7_2_1
  doi: 10.3322/caac.21166
– ident: e_1_2_7_41_1
  doi: 10.1016/j.bbagen.2013.01.010
– ident: e_1_2_7_28_1
  doi: 10.2174/15672050113109990199
– ident: e_1_2_7_52_1
  doi: 10.1155/2009/904836
– ident: e_1_2_7_9_1
  doi: 10.1002/mc.20721
– ident: e_1_2_7_10_1
  doi: 10.1200/JCO.2002.20.4.1026
– ident: e_1_2_7_18_1
  doi: 10.1016/j.bcmd.2010.03.008
– ident: e_1_2_7_38_1
  doi: 10.1002/ijc.10269
– ident: e_1_2_7_23_1
  doi: 10.1016/j.toxlet.2013.07.022
– ident: e_1_2_7_11_1
  doi: 10.1007/s10549-010-0870-7
– ident: e_1_2_7_3_1
  doi: 10.1056/NEJMra050776
– ident: e_1_2_7_32_1
  doi: 10.1371/journal.pone.0066931
– ident: e_1_2_7_50_1
  doi: 10.1016/j.cell.2011.11.016
– ident: e_1_2_7_34_1
  doi: 10.1016/j.bbrc.2011.12.141
– ident: e_1_2_7_53_1
  doi: 10.1007/978-1-61779-012-6_9
– ident: e_1_2_7_20_1
  doi: 10.1371/journal.pone.0050638
– ident: e_1_2_7_7_1
  doi: 10.1016/j.mrfmmm.2005.02.028
– ident: e_1_2_7_48_1
  doi: 10.1093/annonc/mdt159
– ident: e_1_2_7_31_1
  doi: 10.1016/j.cbi.2014.12.002
– ident: e_1_2_7_36_1
  doi: 10.1007/s10549-013-2563-5
– ident: e_1_2_7_46_1
  doi: 10.18632/oncotarget.10459
– ident: e_1_2_7_49_1
  doi: 10.1007/s10549-013-2406-4
– ident: e_1_2_7_30_1
  doi: 10.1007/s10549-015-3376-5
– ident: e_1_2_7_42_1
  doi: 10.1038/nrc2657
– ident: e_1_2_7_40_1
  doi: 10.1016/j.jsbmb.2006.09.028
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