LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity

VeA is the founding member of the velvet superfamily of fungal regulatory proteins. This protein is involved in light response and coordinates sexual reproduction and secondary metabolism in Aspergillus nidulans. In the dark, VeA bridges VelB and LaeA to form the VelB-VeA-LaeA (velvet) complex. The...

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Published inPLoS genetics Vol. 6; no. 12; p. e1001226
Main Authors Sarikaya Bayram, Ozlem, Bayram, Ozgür, Valerius, Oliver, Park, Hee Soo, Irniger, Stefan, Gerke, Jennifer, Ni, Min, Han, Kap-Hoon, Yu, Jae-Hyuk, Braus, Gerhard H
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 01.12.2010
Public Library of Science (PLoS)
Subjects
Aspergillus
Aspergillus nidulans
Aspergillus nidulans - genetics
Aspergillus nidulans - growth & development
Aspergillus nidulans - metabolism
Aspergillus nidulans - radiation effects
Biochemistry
Cell Biology/Cell Signaling
Cell Biology/Gene Expression
Cell Biology/Microbial Growth and Development
Cell Biology/Morphogenesis and Cell Biology
Colleges & universities
Developmental Biology
Experiments
Fungal Proteins - genetics
Fungal Proteins - metabolism
Fungi
Gene Expression Regulation, Fungal - radiation effects
Genetic aspects
Genetics
Hybridization
Light
Metabolites
Microbial metabolism
Molecular Biology
Multigene Family
Physiological aspects
Protein Binding
Proteins
United States
South Korea
Germany
Online AccessGet full text

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Abstract VeA is the founding member of the velvet superfamily of fungal regulatory proteins. This protein is involved in light response and coordinates sexual reproduction and secondary metabolism in Aspergillus nidulans. In the dark, VeA bridges VelB and LaeA to form the VelB-VeA-LaeA (velvet) complex. The VeA-like protein VelB is another developmental regulator, and LaeA has been known as global regulator of secondary metabolism. In this study, we show that VelB forms a second light-regulated developmental complex together with VosA, another member of the velvet family, which represses asexual development. LaeA plays a key role, not only in secondary metabolism, but also in directing formation of the VelB-VosA and VelB-VeA-LaeA complexes. LaeA controls VeA modification and protein levels and possesses additional developmental functions. The laeA null mutant results in constitutive sexual differentiation, indicating that LaeA plays a pivotal role in inhibiting sexual development in response to light. Moreover, the absence of LaeA results in the formation of significantly smaller fruiting bodies. This is due to the lack of a specific globose cell type (Hülle cells), which nurse the young fruiting body during development. This suggests that LaeA controls Hülle cells. In summary, LaeA plays a dynamic role in fungal morphological and chemical development, and it controls expression, interactions, and modification of the velvet regulators.
AbstractList VeA is the founding member of the velvet superfamily of fungal regulatory proteins. This protein is involved in light response and coordinates sexual reproduction and secondary metabolism in Aspergillus nidulans. In the dark, VeA bridges VelB and LaeA to form the VelB-VeA-LaeA (velvet) complex. The VeA-like protein VelB is another developmental regulator, and LaeA has been known as global regulator of secondary metabolism. In this study, we show that VelB forms a second light-regulated developmental complex together with VosA, another member of the velvet family, which represses asexual development. LaeA plays a key role, not only in secondary metabolism, but also in directing formation of the VelB-VosA and VelB-VeA-LaeA complexes. LaeA controls VeA modification and protein levels and possesses additional developmental functions. The laeA null mutant results in constitutive sexual differentiation, indicating that LaeA plays a pivotal role in inhibiting sexual development in response to light. Moreover, the absence of LaeA results in the formation of significantly smaller fruiting bodies. This is due to the lack of a specific globose cell type (Hülle cells), which nurse the young fruiting body during development. This suggests that LaeA controls Hülle cells. In summary, LaeA plays a dynamic role in fungal morphological and chemical development, and it controls expression, interactions, and modification of the velvet regulators.
VeA is the founding member of the velvet superfamily of fungal regulatory proteins. This protein is involved in light response and coordinates sexual reproduction and secondary metabolism in Aspergillus nidulans. In the dark, VeA bridges VelB and LaeA to form the VelB-VeA-LaeA (velvet) complex. The VeA-like protein VelB is another developmental regulator, and LaeA has been known as global regulator of secondary metabolism. In this study, we show that VelB forms a second light-regulated developmental complex together with VosA, another member of the velvet family, which represses asexual development. LaeA plays a key role, not only in secondary metabolism, but also in directing formation of the VelB-VosA and VelB-VeA-LaeA complexes. LaeA controls VeA modification and protein levels and possesses additional developmental functions. The laeA null mutant results in constitutive sexual differentiation, indicating that LaeA plays a pivotal role in inhibiting sexual development in response to light. Moreover, the absence of LaeA results in the formation of significantly smaller fruiting bodies. This is due to the lack of a specific globose cell type (Hulle cells), which nurse the young fruiting body during development. This suggests that LaeA controls Hulle cells. In summary, LaeA plays a dynamic role in fungal morphological and chemical development, and it controls expression, interactions, and modification of the velvet regulators.
VeA is the founding member of the velvet superfamily of fungal regulatory proteins. This protein is involved in light response and coordinates sexual reproduction and secondary metabolism in Aspergillus nidulans. In the dark, VeA bridges VelB and LaeA to form the VelB-VeA-LaeA (velvet) complex. The VeA-like protein VelB is another developmental regulator, and LaeA has been known as global regulator of secondary metabolism. In this study, we show that VelB forms a second light-regulated developmental complex together with VosA, another member of the velvet family, which represses asexual development. LaeA plays a key role, not only in secondary metabolism, but also in directing formation of the VelB-VosA and VelB-VeA-LaeA complexes. LaeA controls VeA modification and protein levels and possesses additional developmental functions. The laeA null mutant results in constitutive sexual differentiation, indicating that LaeA plays a pivotal role in inhibiting sexual development in response to light. Moreover, the absence of LaeA results in the formation of significantly smaller fruiting bodies. This is due to the lack of a specific globose cell type (Huelle cells), which nurse the young fruiting body during development. This suggests that LaeA controls Huelle cells. In summary, LaeA plays a dynamic role in fungal morphological and chemical development, and it controls expression, interactions, and modification of the velvet regulators. Numerous fungi have the potential to infect immunocompromised patients or to contaminate and spoil our nutrients. They represent an increasing danger that threatens public health and agriculture. This requires improved understanding of fungal growth, development, dissemination of spores, and mycotoxin production. We have discovered two related fungal specific protein complexes that provide a molecular link among spore formation, fungal development, and secondary metabolite production. The subunit allocation of both complexes depends on each other, and they share a common subunit. These complexes comprise three related and in fungi conserved proteins of the velvet family that function in concert with a known regulator of secondary metabolism, LaeA. This protein controls the formation of both complexes but is only a part of the trimeric complex. We found that this regulator of secondary metabolism also possesses several developmental control functions in gene expression. These protein complexes discovered in the fungal model system Aspergillus nidulans are conserved in fungal pathogens where they might provide novel insights for understanding growth, development, and interaction with their respective hosts.
VeA is the founding member of the velvet superfamily of fungal regulatory proteins. This protein is involved in light response and coordinates sexual reproduction and secondary metabolism in Aspergillus nidulans . In the dark, VeA bridges VelB and LaeA to form the VelB-VeA-LaeA (velvet) complex. The VeA-like protein VelB is another developmental regulator, and LaeA has been known as global regulator of secondary metabolism. In this study, we show that VelB forms a second light-regulated developmental complex together with VosA, another member of the velvet family, which represses asexual development. LaeA plays a key role, not only in secondary metabolism, but also in directing formation of the VelB-VosA and VelB-VeA-LaeA complexes. LaeA controls VeA modification and protein levels and possesses additional developmental functions. The laeA null mutant results in constitutive sexual differentiation, indicating that LaeA plays a pivotal role in inhibiting sexual development in response to light. Moreover, the absence of LaeA results in the formation of significantly smaller fruiting bodies. This is due to the lack of a specific globose cell type (Hülle cells), which nurse the young fruiting body during development. This suggests that LaeA controls Hülle cells. In summary, LaeA plays a dynamic role in fungal morphological and chemical development, and it controls expression, interactions, and modification of the velvet regulators. Numerous fungi have the potential to infect immunocompromised patients or to contaminate and spoil our nutrients. They represent an increasing danger that threatens public health and agriculture. This requires improved understanding of fungal growth, development, dissemination of spores, and mycotoxin production. We have discovered two related fungal specific protein complexes that provide a molecular link among spore formation, fungal development, and secondary metabolite production. The subunit allocation of both complexes depends on each other, and they share a common subunit. These complexes comprise three related and in fungi conserved proteins of the velvet family that function in concert with a known regulator of secondary metabolism, LaeA. This protein controls the formation of both complexes but is only a part of the trimeric complex. We found that this regulator of secondary metabolism also possesses several developmental control functions in gene expression. These protein complexes discovered in the fungal model system Aspergillus nidulans are conserved in fungal pathogens where they might provide novel insights for understanding growth, development, and interaction with their respective hosts.
  VeA is the founding member of the velvet superfamily of fungal regulatory proteins. This protein is involved in light response and coordinates sexual reproduction and secondary metabolism in Aspergillus nidulans. In the dark, VeA bridges VelB and LaeA to form the VelB-VeA-LaeA (velvet) complex. The VeA-like protein VelB is another developmental regulator, and LaeA has been known as global regulator of secondary metabolism. In this study, we show that VelB forms a second light-regulated developmental complex together with VosA, another member of the velvet family, which represses asexual development. LaeA plays a key role, not only in secondary metabolism, but also in directing formation of the VelB-VosA and VelB-VeA-LaeA complexes. LaeA controls VeA modification and protein levels and possesses additional developmental functions. The laeA null mutant results in constitutive sexual differentiation, indicating that LaeA plays a pivotal role in inhibiting sexual development in response to light. Moreover, the absence of LaeA results in the formation of significantly smaller fruiting bodies. This is due to the lack of a specific globose cell type (Hülle cells), which nurse the young fruiting body during development. This suggests that LaeA controls Hülle cells. In summary, LaeA plays a dynamic role in fungal morphological and chemical development, and it controls expression, interactions, and modification of the velvet regulators.
Audience Academic
Author Park, Hee Soo
Irniger, Stefan
Braus, Gerhard H
Han, Kap-Hoon
Yu, Jae-Hyuk
Bayram, Ozgür
Gerke, Jennifer
Ni, Min
Sarikaya Bayram, Ozlem
Valerius, Oliver
AuthorAffiliation 3 Department of Pharmaceutical Engineering, Woosuk University, Wanju, Korea
1 Institute of Microbiology and Genetics, Department of Molecular Microbiology and Genetics, Georg August University, Göttingen, Germany
2 Departments of Bacteriology and Genetics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
Leibniz Institute for Natural Product Research and Infection Biology, Germany
AuthorAffiliation_xml – name: 2 Departments of Bacteriology and Genetics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
– name: 1 Institute of Microbiology and Genetics, Department of Molecular Microbiology and Genetics, Georg August University, Göttingen, Germany
– name: 3 Department of Pharmaceutical Engineering, Woosuk University, Wanju, Korea
– name: Leibniz Institute for Natural Product Research and Infection Biology, Germany
Author_xml – sequence: 1
  givenname: Ozlem
  surname: Sarikaya Bayram
  fullname: Sarikaya Bayram, Ozlem
  organization: Institute of Microbiology and Genetics, Department of Molecular Microbiology and Genetics, Georg August University, Göttingen, Germany
– sequence: 2
  givenname: Ozgür
  surname: Bayram
  fullname: Bayram, Ozgür
– sequence: 3
  givenname: Oliver
  surname: Valerius
  fullname: Valerius, Oliver
– sequence: 4
  givenname: Hee Soo
  surname: Park
  fullname: Park, Hee Soo
– sequence: 5
  givenname: Stefan
  surname: Irniger
  fullname: Irniger, Stefan
– sequence: 6
  givenname: Jennifer
  surname: Gerke
  fullname: Gerke, Jennifer
– sequence: 7
  givenname: Min
  surname: Ni
  fullname: Ni, Min
– sequence: 8
  givenname: Kap-Hoon
  surname: Han
  fullname: Han, Kap-Hoon
– sequence: 9
  givenname: Jae-Hyuk
  surname: Yu
  fullname: Yu, Jae-Hyuk
– sequence: 10
  givenname: Gerhard H
  surname: Braus
  fullname: Braus, Gerhard H
BackLink https://www.ncbi.nlm.nih.gov/pubmed/21152013$$D View this record in MEDLINE/PubMed
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2010 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Citation: Sarikaya Bayram Ö, Bayram Ö, Valerius O, Park HS, Irniger S, et al. (2010) LaeA Control of Velvet Family Regulatory Proteins for Light-Dependent Development and Fungal Cell-Type Specificity. PLoS Genet 6(12): e1001226. doi:10.1371/journal.pgen.1001226
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Conceived and designed the experiments: ÖSB ÖB JHY GHB. Performed the experiments: ÖSB ÖB OV HSP JG MN. Analyzed the data: ÖSB ÖB OV HSP SI KHH JHY GHB. Contributed reagents/materials/analysis tools: GHB. Wrote the paper: ÖSB ÖB SI JHY GHB.
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Snippet VeA is the founding member of the velvet superfamily of fungal regulatory proteins. This protein is involved in light response and coordinates sexual...
  VeA is the founding member of the velvet superfamily of fungal regulatory proteins. This protein is involved in light response and coordinates sexual...
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StartPage e1001226
SubjectTerms Aspergillus
Aspergillus nidulans
Aspergillus nidulans - genetics
Aspergillus nidulans - growth & development
Aspergillus nidulans - metabolism
Aspergillus nidulans - radiation effects
Biochemistry
Cell Biology/Cell Signaling
Cell Biology/Gene Expression
Cell Biology/Microbial Growth and Development
Cell Biology/Morphogenesis and Cell Biology
Colleges & universities
Developmental Biology
Experiments
Fungal Proteins - genetics
Fungal Proteins - metabolism
Fungi
Gene Expression Regulation, Fungal - radiation effects
Genetic aspects
Genetics
Hybridization
Light
Metabolites
Microbial metabolism
Molecular Biology
Multigene Family
Physiological aspects
Protein Binding
Proteins
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Title LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity
URI https://www.ncbi.nlm.nih.gov/pubmed/21152013
https://search.proquest.com/docview/820786692
https://search.proquest.com/docview/907148621
https://pubmed.ncbi.nlm.nih.gov/PMC2996326
https://doaj.org/article/71863ae5d41f473888470d50e196a383
http://dx.doi.org/10.1371/journal.pgen.1001226
Volume 6
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