An aspartyl protease directs malaria effector proteins to the host cell

• Published in: Nature (London) Vol. 463; no. 7281; pp. 627 - 631
• Main Authors: Hodder, Anthony N, Simpson, Richard J, Crabb, Brendan S, Patsiouras, Heather, Boddey, Justin A, Cowman, Alan F, Pearce, J. Andrew, Günther, Svenja, Gilson, Paul R, de Koning-Ward, Tania F, Kapp, Eugene A
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.02.2010; Nature Publishing Group
• Subjects: 631/154/555; 631/250/255/1629; 631/45/607/468; 631/80/2023/2022; Amino Acid Motifs; Amino acids; Animals; Antimalarials - pharmacology; Aspartate; Aspartic Acid Endopeptidases - genetics; Aspartic Acid Endopeptidases - isolation & purification; Aspartic Acid Endopeptidases - metabolism; Biological and medical sciences; Cleavage; E coli; Effectors; Endoplasmic Reticulum - enzymology; Endoplasmic Reticulum - metabolism; Erythrocytes; Erythrocytes - cytology; Erythrocytes - metabolism; Erythrocytes - parasitology; Exports; HIV Protease Inhibitors - pharmacology; Human protozoal diseases; Humanities and Social Sciences; Humans; Infectious diseases; International trade; Malaria; Malaria, Falciparum - blood; Malaria, Falciparum - metabolism; Malaria, Falciparum - parasitology; Malaria, Falciparum - pathology; Mass spectrometry; Medical sciences; multidisciplinary; Parasites; Parasitic diseases; Plasmodium falciparum; Plasmodium falciparum - enzymology; Plasmodium falciparum - genetics; Plasmodium falciparum - metabolism; Protease; Proteases; Protein Processing, Post-Translational - drug effects; Protein Sorting Signals; Protein Transport; Proteins; Protozoal diseases; Protozoan Proteins - chemistry; Protozoan Proteins - metabolism; Questions and answers; Science; Science (multidisciplinary); Vector-borne diseases; Infection; Protozoal disease; Malaria; Host; Parasitosis; Effector; Protein

Plasmodium falciparum causes the virulent form of malaria and disease manifestations are linked to growth inside infected erythrocytes. To survive and evade host responses the parasite remodels the erythrocyte by exporting several hundred effector proteins beyond the surrounding parasitophorous vacu...