Generation of Neutralizing Antibodies and Divergence of SIVmac239 in Cynomolgus Macaques Following Short-Term Early Antiretroviral Therapy

• Published in: PLoS pathogens Vol. 6; no. 9; p. e1001084
• Main Authors: Özkaya Şahin, Gülşen, Bowles, Emma J., Parker, Joe, Uchtenhagen, Hannes, Sheik-Khalil, Enas, Taylor, Stephen, Pybus, Oliver G., Mäkitalo, Barbro, Walther-Jallow, Lilian, Spångberg, Mats, Thorstensson, Rigmor, Achour, Adnane, Fenyö, Eva Maria, Stewart-Jones, Guillaume B. E., Spetz, Anna-Lena
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.09.2010; Public Library of Science (PLoS)
• Subjects: Acids; Amino Acid Substitution; Animals; Anti-Retroviral Agents - therapeutic use; Antibodies, Neutralizing - immunology; Antibodies, Neutralizing - therapeutic use; Basic Medicine; Biological Evolution; Care and treatment; CD4 lymphocytes; Cynomolgus; Diseases; DNA sequencing; Drug therapy; Evolution; Evolutionary Biology/Bioinformatics; Genetic aspects; Genetic diversity; Genetic Variation; HIV; HIV infection; Human immunodeficiency virus; Human immunodeficiency virus 1; Immunoglobulin G - blood; Immunology/Immunity to Infections; Infections; Infectious Diseases/HIV Infection and AIDS; Macaca; Macaca fascicularis; Macaques; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; Membrane Glycoproteins - genetics; Methods; Microbiology in the Medical Area; Mikrobiologi inom det medicinska området; Mutation; Mutation - genetics; Nucleotide sequencing; Phylogeny; Plasma; Polymerase Chain Reaction; RNA, Viral; Simian Acquired Immunodeficiency Syndrome - drug therapy; Simian Acquired Immunodeficiency Syndrome - immunology; Simian Acquired Immunodeficiency Syndrome - virology; Simian immunodeficiency virus; Simian Immunodeficiency Virus - genetics; Simian Immunodeficiency Virus - immunology; Simian Immunodeficiency Virus - pathogenicity; Studies; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; T-Lymphocytes - virology; Viral Envelope Proteins - genetics; Viral Load - drug effects; Viral Load - immunology; Viremia - drug therapy; Viremia - immunology; Virology/Animal Models of Infection; Viruses; Sweden

Neutralizing antibodies (NAb) able to react to heterologous viruses are generated during natural HIV-1 infection in some individuals. Further knowledge is required in order to understand the factors contributing to induction of cross-reactive NAb responses. Here a well-established model of experimen...