Mechanisms of NAFLD development and therapeutic strategies

• Published in: Nature medicine Vol. 24; no. 7; pp. 908 - 922
• Main Authors: Friedman, Scott L., Neuschwander-Tetri, Brent A., Rinella, Mary, Sanyal, Arun J.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.07.2018; Nature Publishing Group
• Subjects: 631/154/309/2144; 692/308/2779/109; Abnormalities; Animal models; Biomedical and Life Sciences; Biomedicine; Cancer Research; Care and treatment; Cellular signal transduction; Cirrhosis; Clinical trials; Comorbidity; Diabetes mellitus; Diagnosis; Drug development; Drug efficacy; Fatty liver; Gene expression; Genetic aspects; Infectious Diseases; Liver; Liver cancer; Liver cirrhosis; Liver diseases; Medical schools; Metabolic Diseases; Metabolic disorders; Metabolic syndrome; Molecular Medicine; Neurosciences; Review Article; Therapeutic applications; Type 2 diabetes

There has been a rise in the prevalence of nonalcoholic fatty liver disease (NAFLD), paralleling a worldwide increase in diabetes and metabolic syndrome. NAFLD, a continuum of liver abnormalities from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), has a variable course but c...